Isobio software: biological dose distribution and biological dose volume histogram from physical dose conversion using linear-quadratic-linear model
Purpose: To develop an in-house software program that is able to calculate and generate the biological dose distribution and biological dose volume histogram by physical dose conversion using the linear-quadratic-linear (LQL) model. Material and methods : The Isobio software was developed using...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2017-02-01
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| Series: | Journal of Contemporary Brachytherapy |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Isobio-software-biological-dose-distribution-r-nand-biological-dose-volume-histogram-r-nfrom-physical-dose-conversion-using-r-nlinear-quadratic-linear-model,54,29512,1,1.html |
| _version_ | 1811265404842016768 |
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| author | Tanwiwat Jaikuna Phatchareewan Khadsiri Nisa Chawapun Suwit Saekho Ekkasit Tharavichitkul |
| author_facet | Tanwiwat Jaikuna Phatchareewan Khadsiri Nisa Chawapun Suwit Saekho Ekkasit Tharavichitkul |
| author_sort | Tanwiwat Jaikuna |
| collection | DOAJ |
| description | Purpose: To develop an in-house software program that is able to calculate and generate the biological dose distribution and biological dose volume histogram by physical dose conversion using the linear-quadratic-linear (LQL) model.
Material and methods : The Isobio software was developed using MATLAB version 2014b to calculate and generate the biological dose distribution and biological dose volume histograms. The physical dose from each voxel in treatment planning was extracted through Computational Environment for Radiotherapy Research (CERR), and the accuracy was verified by the differentiation between the dose volume histogram from CERR and the treatment planning system.
An equivalent dose in 2 Gy fraction (EQD2) was calculated using biological effective dose (BED) based on the LQL model. The software calculation and the manual calculation were compared for EQD2 verification with pair t-test statistical analysis using IBM SPSS Statistics version 22 (64-bit).
Results: Two and three-dimensional biological dose distribution and biological dose volume histogram were displayed correctly by the Isobio software. Different physical doses were found between CERR and treatment planning system (TPS) in Oncentra, with 3.33% in high-risk clinical target volume (HR-CTV) determined by D90%, 0.56% in the bladder, 1.74% in the rectum when determined by D2cc, and less than 1% in Pinnacle. The difference in the EQD2 between the software calculation and the manual calculation was not significantly different with 0.00% at p-values 0.820, 0.095, and 0.593 for external beam radiation therapy (EBRT) and 0.240, 0.320, and 0.849 for brachytherapy (BT) in HR-CTV, bladder, and rectum, respectively.
Conclusions : The Isobio software is a feasible tool to generate the biological dose distribution and biological dose volume histogram for treatment plan evaluation in both EBRT and BT. |
| first_indexed | 2024-04-12T20:23:13Z |
| format | Article |
| id | doaj.art-e6bf5bf3a9924b5c8b212cca7915d802 |
| institution | Directory Open Access Journal |
| issn | 1689-832X 2081-2841 |
| language | English |
| last_indexed | 2024-04-12T20:23:13Z |
| publishDate | 2017-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Journal of Contemporary Brachytherapy |
| spelling | doaj.art-e6bf5bf3a9924b5c8b212cca7915d8022022-12-22T03:17:56ZengTermedia Publishing HouseJournal of Contemporary Brachytherapy1689-832X2081-28412017-02-0191445110.5114/jcb.2017.6608229512Isobio software: biological dose distribution and biological dose volume histogram from physical dose conversion using linear-quadratic-linear modelTanwiwat JaikunaPhatchareewan KhadsiriNisa ChawapunSuwit SaekhoEkkasit TharavichitkulPurpose: To develop an in-house software program that is able to calculate and generate the biological dose distribution and biological dose volume histogram by physical dose conversion using the linear-quadratic-linear (LQL) model. Material and methods : The Isobio software was developed using MATLAB version 2014b to calculate and generate the biological dose distribution and biological dose volume histograms. The physical dose from each voxel in treatment planning was extracted through Computational Environment for Radiotherapy Research (CERR), and the accuracy was verified by the differentiation between the dose volume histogram from CERR and the treatment planning system. An equivalent dose in 2 Gy fraction (EQD2) was calculated using biological effective dose (BED) based on the LQL model. The software calculation and the manual calculation were compared for EQD2 verification with pair t-test statistical analysis using IBM SPSS Statistics version 22 (64-bit). Results: Two and three-dimensional biological dose distribution and biological dose volume histogram were displayed correctly by the Isobio software. Different physical doses were found between CERR and treatment planning system (TPS) in Oncentra, with 3.33% in high-risk clinical target volume (HR-CTV) determined by D90%, 0.56% in the bladder, 1.74% in the rectum when determined by D2cc, and less than 1% in Pinnacle. The difference in the EQD2 between the software calculation and the manual calculation was not significantly different with 0.00% at p-values 0.820, 0.095, and 0.593 for external beam radiation therapy (EBRT) and 0.240, 0.320, and 0.849 for brachytherapy (BT) in HR-CTV, bladder, and rectum, respectively. Conclusions : The Isobio software is a feasible tool to generate the biological dose distribution and biological dose volume histogram for treatment plan evaluation in both EBRT and BT.https://www.termedia.pl/Isobio-software-biological-dose-distribution-r-nand-biological-dose-volume-histogram-r-nfrom-physical-dose-conversion-using-r-nlinear-quadratic-linear-model,54,29512,1,1.htmlbiological dose EQD2 software LQL model |
| spellingShingle | Tanwiwat Jaikuna Phatchareewan Khadsiri Nisa Chawapun Suwit Saekho Ekkasit Tharavichitkul Isobio software: biological dose distribution and biological dose volume histogram from physical dose conversion using linear-quadratic-linear model Journal of Contemporary Brachytherapy biological dose EQD2 software LQL model |
| title | Isobio software: biological dose distribution
and biological dose volume histogram
from physical dose conversion using
linear-quadratic-linear model |
| title_full | Isobio software: biological dose distribution
and biological dose volume histogram
from physical dose conversion using
linear-quadratic-linear model |
| title_fullStr | Isobio software: biological dose distribution
and biological dose volume histogram
from physical dose conversion using
linear-quadratic-linear model |
| title_full_unstemmed | Isobio software: biological dose distribution
and biological dose volume histogram
from physical dose conversion using
linear-quadratic-linear model |
| title_short | Isobio software: biological dose distribution
and biological dose volume histogram
from physical dose conversion using
linear-quadratic-linear model |
| title_sort | isobio software biological dose distribution and biological dose volume histogram from physical dose conversion using linear quadratic linear model |
| topic | biological dose EQD2 software LQL model |
| url | https://www.termedia.pl/Isobio-software-biological-dose-distribution-r-nand-biological-dose-volume-histogram-r-nfrom-physical-dose-conversion-using-r-nlinear-quadratic-linear-model,54,29512,1,1.html |
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