Triglyceride–Glucose Index May Predict Renal Survival in Patients with IgA Nephropathy
<b>Background:</b> The triglyceride–glucose (TyG) index is a simple, novel and reliable surrogate marker of insulin resistance. However, evidence for the prognostic impact of an elevated TyG index on IgA nephropathy (IgAN) is limited. Therefore, we evaluated the relationship between the...
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/2077-0383/11/17/5176 |
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| author | Aiya Qin Jiaxing Tan Siqing Wang Lingqiu Dong Zheng Jiang Dandan Yang Huan Zhou Xiaoyuan Zhou Yi Tang Wei Qin |
| author_facet | Aiya Qin Jiaxing Tan Siqing Wang Lingqiu Dong Zheng Jiang Dandan Yang Huan Zhou Xiaoyuan Zhou Yi Tang Wei Qin |
| author_sort | Aiya Qin |
| collection | DOAJ |
| description | <b>Background:</b> The triglyceride–glucose (TyG) index is a simple, novel and reliable surrogate marker of insulin resistance. However, evidence for the prognostic impact of an elevated TyG index on IgA nephropathy (IgAN) is limited. Therefore, we evaluated the relationship between the TyG index and the risk of renal progression in IgAN. <b>Method:</b> This cohort study involved biopsy-proven IgAN between January 2009 and December 2018 in West China Hospital, in which patients were assigned to two groups based on the cut-off value of TyG using receiver operating characteristic (ROC) curves. A 1:1 matched-pair analysis was established to optimize the bias in IgAN by propensity score matching (PSM). The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. The composite endpoint was defined by eGFR decreased ≥50% of the baseline level, end-stage kidney disease (ESKD), renal transplantation and/or death. Univariable and multivariable Cox proportional hazard models were applied to confirm the predictive value of the optimal marker. <b>Results:</b> Before PSM, a total of 1210 participants were ultimately included. During a median follow-up period of 55.8 months (range 37.20–79.09 months), 129 participants progressed to the composite endpoint (10.7%). After PSM, 366 patients were enrolled in the matched cohort, of whom 34 (9.3%) patients reached the endpoints. Based on the cut-off value of the TyG index, patients were divided into the low TyG index group (TyG ≤ 8.72, n = 690) and the high TyG index group (TyG > 8.72, n = 520). Further analysis demonstrated that a higher TyG index was significantly associated with a higher risk of reaching composite endpoints in IgAN patients in both the unmatched and matched cohorts (before PSM: HR 2.509, 95% CI 1.396–4.511, <i>p</i> = 0.002; after PSM: HR 2.654, 95% CI 1.299–5.423, <i>p</i> = 0.007). <b>Conclusion:</b> A high TyG index is associated with a higher risk of renal progression. |
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| spelling | doaj.art-e6bfd0618ded4d82bcb094e15c775c742023-11-23T13:29:04ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011117517610.3390/jcm11175176Triglyceride–Glucose Index May Predict Renal Survival in Patients with IgA NephropathyAiya Qin0Jiaxing Tan1Siqing Wang2Lingqiu Dong3Zheng Jiang4Dandan Yang5Huan Zhou6Xiaoyuan Zhou7Yi Tang8Wei Qin9West China School of Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Medicine, Sichuan University, Chengdu 610041, ChinaWest China School of Public Health, West China Forth Hospital, Sichuan University, Chengdu 610093, ChinaDepartment of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, China<b>Background:</b> The triglyceride–glucose (TyG) index is a simple, novel and reliable surrogate marker of insulin resistance. However, evidence for the prognostic impact of an elevated TyG index on IgA nephropathy (IgAN) is limited. Therefore, we evaluated the relationship between the TyG index and the risk of renal progression in IgAN. <b>Method:</b> This cohort study involved biopsy-proven IgAN between January 2009 and December 2018 in West China Hospital, in which patients were assigned to two groups based on the cut-off value of TyG using receiver operating characteristic (ROC) curves. A 1:1 matched-pair analysis was established to optimize the bias in IgAN by propensity score matching (PSM). The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. The composite endpoint was defined by eGFR decreased ≥50% of the baseline level, end-stage kidney disease (ESKD), renal transplantation and/or death. Univariable and multivariable Cox proportional hazard models were applied to confirm the predictive value of the optimal marker. <b>Results:</b> Before PSM, a total of 1210 participants were ultimately included. During a median follow-up period of 55.8 months (range 37.20–79.09 months), 129 participants progressed to the composite endpoint (10.7%). After PSM, 366 patients were enrolled in the matched cohort, of whom 34 (9.3%) patients reached the endpoints. Based on the cut-off value of the TyG index, patients were divided into the low TyG index group (TyG ≤ 8.72, n = 690) and the high TyG index group (TyG > 8.72, n = 520). Further analysis demonstrated that a higher TyG index was significantly associated with a higher risk of reaching composite endpoints in IgAN patients in both the unmatched and matched cohorts (before PSM: HR 2.509, 95% CI 1.396–4.511, <i>p</i> = 0.002; after PSM: HR 2.654, 95% CI 1.299–5.423, <i>p</i> = 0.007). <b>Conclusion:</b> A high TyG index is associated with a higher risk of renal progression.https://www.mdpi.com/2077-0383/11/17/5176triglyceride glucose indexTyG indexIgA nephropathyrenal survival |
| spellingShingle | Aiya Qin Jiaxing Tan Siqing Wang Lingqiu Dong Zheng Jiang Dandan Yang Huan Zhou Xiaoyuan Zhou Yi Tang Wei Qin Triglyceride–Glucose Index May Predict Renal Survival in Patients with IgA Nephropathy Journal of Clinical Medicine triglyceride glucose index TyG index IgA nephropathy renal survival |
| title | Triglyceride–Glucose Index May Predict Renal Survival in Patients with IgA Nephropathy |
| title_full | Triglyceride–Glucose Index May Predict Renal Survival in Patients with IgA Nephropathy |
| title_fullStr | Triglyceride–Glucose Index May Predict Renal Survival in Patients with IgA Nephropathy |
| title_full_unstemmed | Triglyceride–Glucose Index May Predict Renal Survival in Patients with IgA Nephropathy |
| title_short | Triglyceride–Glucose Index May Predict Renal Survival in Patients with IgA Nephropathy |
| title_sort | triglyceride glucose index may predict renal survival in patients with iga nephropathy |
| topic | triglyceride glucose index TyG index IgA nephropathy renal survival |
| url | https://www.mdpi.com/2077-0383/11/17/5176 |
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