Medullary colon carcinoma with microsatellite instability: case report
Colorectal cancer is the third most common neoplasm and the second most lethal worldwide. The most common histological type is adenocarcinoma, characterized by its glandular pattern. Medullary colon carcinoma is a rare histological variant of colorectal cancer, characterized by a predominantly solid...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de Radioterapia
2024-02-01
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| Series: | Brazilian Journal of Oncology |
| Subjects: | |
| Online Access: | https://www.brazilianjournalofoncology.com.br/details/273/en-US/medullary-colon-carcinoma-with-microsatellite-instability--case-report |
| _version_ | 1797243257460097024 |
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| author | Mayra Wilma Martins Cardoso Soares José Walter Feitosa Gomes Elam Vasconcelos de Aquino Igor Santos Costa Gabriel Sampaio Feitosa Mariana Macambira Noronha Leonardo Saraiva Pontes |
| author_facet | Mayra Wilma Martins Cardoso Soares José Walter Feitosa Gomes Elam Vasconcelos de Aquino Igor Santos Costa Gabriel Sampaio Feitosa Mariana Macambira Noronha Leonardo Saraiva Pontes |
| author_sort | Mayra Wilma Martins Cardoso Soares |
| collection | DOAJ |
| description | Colorectal cancer is the third most common neoplasm and the second most lethal worldwide. The most common histological type is adenocarcinoma, characterized by its glandular pattern. Medullary colon carcinoma is a rare histological variant of colorectal cancer, characterized by a predominantly solid architecture, poorly differentiated or undifferentiated morphology, often associated with an anomalous immunophenotype and microsatellite instability. The present study reports a case in an academic service of general surgery of a 74-year-old patient who presented with a tumor of the ascending colon, histologically with an exuberant lymphocytic infiltrate, suggestive of large cell lymphoma, but which was revealed by subsequent immunohistochemistry to be medullary carcinoma of the colon with microsatellite instability. |
| first_indexed | 2024-03-07T23:45:40Z |
| format | Article |
| id | doaj.art-e6c0e85ab54e40ebb7e3c21858decacb |
| institution | Directory Open Access Journal |
| issn | 2526-8732 |
| language | English |
| last_indexed | 2024-04-24T18:52:14Z |
| publishDate | 2024-02-01 |
| publisher | Sociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de Radioterapia |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj.art-e6c0e85ab54e40ebb7e3c21858decacb2024-03-26T19:30:43ZengSociedade Brasileira de Oncologia Clínica, Sociedade Brasileira de Cirurgia Clínica and Sociedade Brasileira de RadioterapiaBrazilian Journal of Oncology2526-87322024-02-011910.5935/2526-8732.20240447Medullary colon carcinoma with microsatellite instability: case reportMayra Wilma Martins Cardoso Soares0José Walter Feitosa Gomes1Elam Vasconcelos de Aquino2Igor Santos Costa3Gabriel Sampaio Feitosa4Mariana Macambira Noronha5Leonardo Saraiva Pontes6Instituto Doutor José Frota, General Surgery Center - Fortaleza - Ceará - BrazilInstituto Doutor José Frota, General Surgery Center - Fortaleza - Ceará - BrazilInstituto Doutor José Frota, General Surgery Center - Fortaleza - Ceará - BrazilArgos, Pathology Laboratory - Fortaleza - Ceará - BrazilFederal University of Ceará, Faculty of Medicine - Fortaleza - Ceará - BrazilFederal University of Ceará, Faculty of Medicine - Fortaleza - Ceará - BrazilWalter Cantídio University Hospital, Clinical Oncology Service - Fortaleza - Ceará - BrazilColorectal cancer is the third most common neoplasm and the second most lethal worldwide. The most common histological type is adenocarcinoma, characterized by its glandular pattern. Medullary colon carcinoma is a rare histological variant of colorectal cancer, characterized by a predominantly solid architecture, poorly differentiated or undifferentiated morphology, often associated with an anomalous immunophenotype and microsatellite instability. The present study reports a case in an academic service of general surgery of a 74-year-old patient who presented with a tumor of the ascending colon, histologically with an exuberant lymphocytic infiltrate, suggestive of large cell lymphoma, but which was revealed by subsequent immunohistochemistry to be medullary carcinoma of the colon with microsatellite instability.https://www.brazilianjournalofoncology.com.br/details/273/en-US/medullary-colon-carcinoma-with-microsatellite-instability--case-reportcolonic neoplasmsmicrosatellite instabilitycarcinoma, medullary |
| spellingShingle | Mayra Wilma Martins Cardoso Soares José Walter Feitosa Gomes Elam Vasconcelos de Aquino Igor Santos Costa Gabriel Sampaio Feitosa Mariana Macambira Noronha Leonardo Saraiva Pontes Medullary colon carcinoma with microsatellite instability: case report Brazilian Journal of Oncology colonic neoplasms microsatellite instability carcinoma, medullary |
| title | Medullary colon carcinoma with microsatellite
instability: case report |
| title_full | Medullary colon carcinoma with microsatellite
instability: case report |
| title_fullStr | Medullary colon carcinoma with microsatellite
instability: case report |
| title_full_unstemmed | Medullary colon carcinoma with microsatellite
instability: case report |
| title_short | Medullary colon carcinoma with microsatellite
instability: case report |
| title_sort | medullary colon carcinoma with microsatellite instability case report |
| topic | colonic neoplasms microsatellite instability carcinoma, medullary |
| url | https://www.brazilianjournalofoncology.com.br/details/273/en-US/medullary-colon-carcinoma-with-microsatellite-instability--case-report |
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