Functional Analysis of Brain Imaging Suggests Changes in the Availability of mGluR5 and Altered Connectivity in the Cerebral Cortex of Long-Term Abstaining Males with Alcohol Dependence: A Preliminary Study
Direct in vivo evidence of altered metabotropic glutamate receptor-5 (mGluR5) availability in alcohol-related disorders is lacking. We performed [<sup>11</sup>C]ABP688 positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI) in prolonged abstin...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Life |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-1729/11/6/506 |
| _version_ | 1797532023880941568 |
|---|---|
| author | Yo-Han Joo Jeong-Hee Kim Hang-Keun Kim Young-Don Son Paul Cumming Jong-Hoon Kim |
| author_facet | Yo-Han Joo Jeong-Hee Kim Hang-Keun Kim Young-Don Son Paul Cumming Jong-Hoon Kim |
| author_sort | Yo-Han Joo |
| collection | DOAJ |
| description | Direct in vivo evidence of altered metabotropic glutamate receptor-5 (mGluR5) availability in alcohol-related disorders is lacking. We performed [<sup>11</sup>C]ABP688 positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI) in prolonged abstinent subjects with alcohol dependence to examine alterations of mGluR5 availability, and to investigate their functional significance relating to neural systems-level changes. Twelve prolonged abstinent male subjects with alcohol dependence (median abstinence duration: six months) and ten healthy male controls underwent [<sup>11</sup>C]ABP688 PET imaging and 3-Tesla MRI. For mGluR5 availability, binding potential (BP<sub>ND</sub>) was calculated using the simplified reference tissue model with cerebellar gray matter as the reference region. The initial region-of-interest (ROI)-based analysis yielded no significant group differences in mGluR5 availability. The voxel-based analysis revealed significantly lower [<sup>11</sup>C]ABP688 BP<sub>ND</sub> in the middle temporal and inferior parietal cortices, and higher BP<sub>ND</sub> in the superior temporal cortex in the alcohol dependence group compared with controls. Functional connectivity analysis of the rs-fMRI data employed seed regions identified from the quantitative [<sup>11</sup>C]ABP688 PET analysis, which revealed significantly altered functional connectivity from the inferior parietal cortex seed to the occipital pole and dorsal visual cortex in the alcohol dependence group compared with the control group. To our knowledge, this is the first report on the combined analysis of mGluR5 PET imaging and rs-fMRI in subjects with alcohol dependence. These preliminary results suggest the possibility of region-specific alterations of mGluR5 availability in vivo and related functional connectivity perturbations in prolonged abstinent subjects. |
| first_indexed | 2024-03-10T10:53:09Z |
| format | Article |
| id | doaj.art-e6c162bf1ee44532a6d99aa49cd560ea |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T10:53:09Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-e6c162bf1ee44532a6d99aa49cd560ea2023-11-21T22:08:01ZengMDPI AGLife2075-17292021-05-0111650610.3390/life11060506Functional Analysis of Brain Imaging Suggests Changes in the Availability of mGluR5 and Altered Connectivity in the Cerebral Cortex of Long-Term Abstaining Males with Alcohol Dependence: A Preliminary StudyYo-Han Joo0Jeong-Hee Kim1Hang-Keun Kim2Young-Don Son3Paul Cumming4Jong-Hoon Kim5Neuroscience Research Institute, Gachon University, Incheon 21565, KoreaNeuroscience Research Institute, Gachon University, Incheon 21565, KoreaNeuroscience Research Institute, Gachon University, Incheon 21565, KoreaNeuroscience Research Institute, Gachon University, Incheon 21565, KoreaDepartment of Nuclear Medicine, Inselspital, University of Bern, CH-3010 Bern, SwitzerlandNeuroscience Research Institute, Gachon University, Incheon 21565, KoreaDirect in vivo evidence of altered metabotropic glutamate receptor-5 (mGluR5) availability in alcohol-related disorders is lacking. We performed [<sup>11</sup>C]ABP688 positron emission tomography (PET) and resting-state functional magnetic resonance imaging (rs-fMRI) in prolonged abstinent subjects with alcohol dependence to examine alterations of mGluR5 availability, and to investigate their functional significance relating to neural systems-level changes. Twelve prolonged abstinent male subjects with alcohol dependence (median abstinence duration: six months) and ten healthy male controls underwent [<sup>11</sup>C]ABP688 PET imaging and 3-Tesla MRI. For mGluR5 availability, binding potential (BP<sub>ND</sub>) was calculated using the simplified reference tissue model with cerebellar gray matter as the reference region. The initial region-of-interest (ROI)-based analysis yielded no significant group differences in mGluR5 availability. The voxel-based analysis revealed significantly lower [<sup>11</sup>C]ABP688 BP<sub>ND</sub> in the middle temporal and inferior parietal cortices, and higher BP<sub>ND</sub> in the superior temporal cortex in the alcohol dependence group compared with controls. Functional connectivity analysis of the rs-fMRI data employed seed regions identified from the quantitative [<sup>11</sup>C]ABP688 PET analysis, which revealed significantly altered functional connectivity from the inferior parietal cortex seed to the occipital pole and dorsal visual cortex in the alcohol dependence group compared with the control group. To our knowledge, this is the first report on the combined analysis of mGluR5 PET imaging and rs-fMRI in subjects with alcohol dependence. These preliminary results suggest the possibility of region-specific alterations of mGluR5 availability in vivo and related functional connectivity perturbations in prolonged abstinent subjects.https://www.mdpi.com/2075-1729/11/6/506metabotropic glutamate receptor-5positron emission tomography[<sup>11</sup>C]ABP688functional magnetic resonance imagingalcohol dependence |
| spellingShingle | Yo-Han Joo Jeong-Hee Kim Hang-Keun Kim Young-Don Son Paul Cumming Jong-Hoon Kim Functional Analysis of Brain Imaging Suggests Changes in the Availability of mGluR5 and Altered Connectivity in the Cerebral Cortex of Long-Term Abstaining Males with Alcohol Dependence: A Preliminary Study Life metabotropic glutamate receptor-5 positron emission tomography [<sup>11</sup>C]ABP688 functional magnetic resonance imaging alcohol dependence |
| title | Functional Analysis of Brain Imaging Suggests Changes in the Availability of mGluR5 and Altered Connectivity in the Cerebral Cortex of Long-Term Abstaining Males with Alcohol Dependence: A Preliminary Study |
| title_full | Functional Analysis of Brain Imaging Suggests Changes in the Availability of mGluR5 and Altered Connectivity in the Cerebral Cortex of Long-Term Abstaining Males with Alcohol Dependence: A Preliminary Study |
| title_fullStr | Functional Analysis of Brain Imaging Suggests Changes in the Availability of mGluR5 and Altered Connectivity in the Cerebral Cortex of Long-Term Abstaining Males with Alcohol Dependence: A Preliminary Study |
| title_full_unstemmed | Functional Analysis of Brain Imaging Suggests Changes in the Availability of mGluR5 and Altered Connectivity in the Cerebral Cortex of Long-Term Abstaining Males with Alcohol Dependence: A Preliminary Study |
| title_short | Functional Analysis of Brain Imaging Suggests Changes in the Availability of mGluR5 and Altered Connectivity in the Cerebral Cortex of Long-Term Abstaining Males with Alcohol Dependence: A Preliminary Study |
| title_sort | functional analysis of brain imaging suggests changes in the availability of mglur5 and altered connectivity in the cerebral cortex of long term abstaining males with alcohol dependence a preliminary study |
| topic | metabotropic glutamate receptor-5 positron emission tomography [<sup>11</sup>C]ABP688 functional magnetic resonance imaging alcohol dependence |
| url | https://www.mdpi.com/2075-1729/11/6/506 |
| work_keys_str_mv | AT yohanjoo functionalanalysisofbrainimagingsuggestschangesintheavailabilityofmglur5andalteredconnectivityinthecerebralcortexoflongtermabstainingmaleswithalcoholdependenceapreliminarystudy AT jeongheekim functionalanalysisofbrainimagingsuggestschangesintheavailabilityofmglur5andalteredconnectivityinthecerebralcortexoflongtermabstainingmaleswithalcoholdependenceapreliminarystudy AT hangkeunkim functionalanalysisofbrainimagingsuggestschangesintheavailabilityofmglur5andalteredconnectivityinthecerebralcortexoflongtermabstainingmaleswithalcoholdependenceapreliminarystudy AT youngdonson functionalanalysisofbrainimagingsuggestschangesintheavailabilityofmglur5andalteredconnectivityinthecerebralcortexoflongtermabstainingmaleswithalcoholdependenceapreliminarystudy AT paulcumming functionalanalysisofbrainimagingsuggestschangesintheavailabilityofmglur5andalteredconnectivityinthecerebralcortexoflongtermabstainingmaleswithalcoholdependenceapreliminarystudy AT jonghoonkim functionalanalysisofbrainimagingsuggestschangesintheavailabilityofmglur5andalteredconnectivityinthecerebralcortexoflongtermabstainingmaleswithalcoholdependenceapreliminarystudy |