Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment

Sphingosine 1-Phosphate Receptor 2 Induces Otoprotective Responses to Cisplatin Treatment

Ototoxicity is a major adverse effect of platinum-based chemotherapeutics and currently, there remains a lack of United States Food and Drug Administration-approved therapies to prevent or treat this problem. In our study, we examined the role of the sphingosine 1-phosphate receptor 2 (S1P<sub>...

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Bibliographic Details
Main Authors: Wei Wang, Muthu K. Shanmugam, Ping Xiang, Ting Yu Amelia Yam, Vineet Kumar, Wee Siong Chew, Jing Kai Chang, Muhammad Zulfaqar Bin Ali, Marie J. Y. Reolo, Yee Xin Peh, Siti Nasuha Binte Abdul Karim, Andrew Y.Y. Tan, Takaomi Sanda, Gautam Sethi, Deron R. Herr
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
cisplatin
ototoxicity
sphingosine 1-phosphate
hearing loss
reactive oxygen species
cochlea
acoustic startle response
auditory brainstem response
cym-5478
Online Access:https://www.mdpi.com/2072-6694/12/1/211

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