METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE?
ABSTRACT BACKGROUND: Liver metastases from colorectal cancer are an important public health problem due to the increasing incidence of colorectal cancer worldwide. Synchronous colorectal liver metastasis has been associated with worse survival, but this prognosis is controversial. OBJECTIVE: The...
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| Format: | Article |
| Language: | English |
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Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)
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| Series: | Arquivos de Gastroenterologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018002300258&lng=en&tlng=en |
| _version_ | 1818253944388845568 |
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| author | Claudemiro QUIREZE JUNIOR Andressa Machado Santana BRASIL Lúcio Kenny MORAIS Edmond Raymond Le CAMPION Eliseu José Fleury TAVEIRA Matheus Castrillon RASSI |
| author_facet | Claudemiro QUIREZE JUNIOR Andressa Machado Santana BRASIL Lúcio Kenny MORAIS Edmond Raymond Le CAMPION Eliseu José Fleury TAVEIRA Matheus Castrillon RASSI |
| author_sort | Claudemiro QUIREZE JUNIOR |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Liver metastases from colorectal cancer are an important public health problem due to the increasing incidence of colorectal cancer worldwide. Synchronous colorectal liver metastasis has been associated with worse survival, but this prognosis is controversial. OBJECTIVE: The objective of this study was to evaluate the recurrence-free survival and overall survival between groups of patients with metachronous and synchronous colorectal hepatic metastasis. METHODS: This was a retrospective analysis of medical records of patients with colorectal liver metastases seen from 2013 to 2016, divided into a metachronous and a synchronous group. The Cox regression model and the Kaplan-Meier method with log-rank test were used to compare survival between groups. RESULTS: The mean recurrence-free survival was 9.75 months and 50% at 1 year in the metachronous group and 19.73 months and 63.3% at 1 year in the synchronous group. The mean overall survival was 20.00 months and 6.2% at 3 years in the metachronous group and 30.39 months and 31.6% at 3 years in the synchronous group. Patients with metachronous hepatic metastasis presented worse overall survival in multivariate analysis. The use of biological drugs combined with chemotherapy was related to the best overall survival prognosis. CONCLUSION: Metachronous colorectal hepatic metastasis was associated with a worse prognosis for overall survival. There was no difference in recurrence-free survival between metachronous and synchronous metastases. |
| first_indexed | 2024-12-12T16:48:07Z |
| format | Article |
| id | doaj.art-e6c3791f985b4d59b237f2dbee738d15 |
| institution | Directory Open Access Journal |
| issn | 1678-4219 |
| language | English |
| last_indexed | 2024-12-12T16:48:07Z |
| publisher | Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) |
| record_format | Article |
| series | Arquivos de Gastroenterologia |
| spelling | doaj.art-e6c3791f985b4d59b237f2dbee738d152022-12-22T00:18:25ZengInstituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE)Arquivos de Gastroenterologia1678-421955325826310.1590/s0004-2803.201800000-64S0004-28032018002300258METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE?Claudemiro QUIREZE JUNIORAndressa Machado Santana BRASILLúcio Kenny MORAISEdmond Raymond Le CAMPIONEliseu José Fleury TAVEIRAMatheus Castrillon RASSIABSTRACT BACKGROUND: Liver metastases from colorectal cancer are an important public health problem due to the increasing incidence of colorectal cancer worldwide. Synchronous colorectal liver metastasis has been associated with worse survival, but this prognosis is controversial. OBJECTIVE: The objective of this study was to evaluate the recurrence-free survival and overall survival between groups of patients with metachronous and synchronous colorectal hepatic metastasis. METHODS: This was a retrospective analysis of medical records of patients with colorectal liver metastases seen from 2013 to 2016, divided into a metachronous and a synchronous group. The Cox regression model and the Kaplan-Meier method with log-rank test were used to compare survival between groups. RESULTS: The mean recurrence-free survival was 9.75 months and 50% at 1 year in the metachronous group and 19.73 months and 63.3% at 1 year in the synchronous group. The mean overall survival was 20.00 months and 6.2% at 3 years in the metachronous group and 30.39 months and 31.6% at 3 years in the synchronous group. Patients with metachronous hepatic metastasis presented worse overall survival in multivariate analysis. The use of biological drugs combined with chemotherapy was related to the best overall survival prognosis. CONCLUSION: Metachronous colorectal hepatic metastasis was associated with a worse prognosis for overall survival. There was no difference in recurrence-free survival between metachronous and synchronous metastases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018002300258&lng=en&tlng=enNeoplasias colorretaisMetástase neoplásicaFígadoPrognósticoSobrevida |
| spellingShingle | Claudemiro QUIREZE JUNIOR Andressa Machado Santana BRASIL Lúcio Kenny MORAIS Edmond Raymond Le CAMPION Eliseu José Fleury TAVEIRA Matheus Castrillon RASSI METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE? Arquivos de Gastroenterologia Neoplasias colorretais Metástase neoplásica Fígado Prognóstico Sobrevida |
| title | METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE? |
| title_full | METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE? |
| title_fullStr | METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE? |
| title_full_unstemmed | METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE? |
| title_short | METACHRONOUS COLORECTAL LIVER METASTASES HAS BETTER PROGNOSIS - IS IT TRUE? |
| title_sort | metachronous colorectal liver metastases has better prognosis is it true |
| topic | Neoplasias colorretais Metástase neoplásica Fígado Prognóstico Sobrevida |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032018002300258&lng=en&tlng=en |
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