Efficacy of Omeprazole Powder Paste or Enteric‐Coated Formulation in Healing of Gastric Ulcers in Horses
Background GastroGard, an omeprazole powder paste formulation, is considered the standard treatment for gastric ulcers in horses and is highly effective. Gastrozol, an enteric‐coated omeprazole formulation for horses, has recently become available, but efficacy data are controversial and sparse. Obj...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-05-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.12341 |
| _version_ | 1798029545957228544 |
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| author | K. Birkmann H.K. Junge E. Maischberger M. Wehrli Eser C.C. Schwarzwald |
| author_facet | K. Birkmann H.K. Junge E. Maischberger M. Wehrli Eser C.C. Schwarzwald |
| author_sort | K. Birkmann |
| collection | DOAJ |
| description | Background GastroGard, an omeprazole powder paste formulation, is considered the standard treatment for gastric ulcers in horses and is highly effective. Gastrozol, an enteric‐coated omeprazole formulation for horses, has recently become available, but efficacy data are controversial and sparse. Objectives To investigate the efficacy of GastroGard and Gastrozol at labeled doses (4 and 1 mg of omeprazole per kg bwt, respectively, PO q24h) in healing of gastric ulcers. Animals 40 horses; 9.5 ± 4.6 years; 491 ± 135 kg. Methods Prospective, randomized, blinded study. Horses with an ulcer score ≥1 (Equine Gastric Ulcer Council) were randomly divided into 2 groups and treated for 2 weeks each with GastroGard followed by Gastrozol (A) or vice versa (B). After 2 and 4 weeks, scoring was repeated and compared with baseline. Plasma omeprazole concentrations were measured on the first day of treatment after administration of GastroGard (n = 5) or Gastrozol (n = 5). Results Compared with baseline (squamous score (A) 1.65 ± 0.11, (B) 1.98 ± 0.11), ulcer scores at 2 weeks ((A) 0.89 ± 0.11, (B) 1.01 ± 0.11) and 4 weeks ((A) 1.10 ± 0.12, (B) 0.80 ± 0.12) had significantly decreased in both groups (P < .001), independent of treatment (P = .7). Plasma omeprazole concentrations were significantly higher after GastroGard compared with Gastrozol administration (AUCGG = 2856 (1405‐4576) ng/mL × h, AUCGZ = 604 (430‐1609) ng/mL × h; P = .03). The bioavailability for Gastrozol was 1.26 (95% CI 0.56–2.81) times higher than for GastroGard. Conclusions and Clinical Importance Both Gastrozol and GastroGard, combined with appropriate environmental changes, promote healing of gastric ulcers in horses. However, despite enteric coating of Gastrozol, plasma omeprazole concentrations after single labeled doses were significantly higher with GastroGard. |
| first_indexed | 2024-04-11T19:25:52Z |
| format | Article |
| id | doaj.art-e6c4763a743b4c688ca8ae4f7e8ac111 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-11T19:25:52Z |
| publishDate | 2014-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-e6c4763a743b4c688ca8ae4f7e8ac1112022-12-22T04:07:09ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762014-05-0128392593310.1111/jvim.12341Efficacy of Omeprazole Powder Paste or Enteric‐Coated Formulation in Healing of Gastric Ulcers in HorsesK. Birkmann0H.K. Junge1E. Maischberger2M. Wehrli Eser3C.C. Schwarzwald4Equine Department Vetsuisse Faculty Clinic for Equine Internal Medicine University of Zurich Zurich SwitzerlandEquine Department Vetsuisse Faculty Clinic for Equine Internal Medicine University of Zurich Zurich SwitzerlandEquine Department Vetsuisse Faculty Clinic for Equine Internal Medicine University of Zurich Zurich SwitzerlandEquine Department Vetsuisse Faculty Clinic for Equine Internal Medicine University of Zurich Zurich SwitzerlandEquine Department Vetsuisse Faculty Clinic for Equine Internal Medicine University of Zurich Zurich SwitzerlandBackground GastroGard, an omeprazole powder paste formulation, is considered the standard treatment for gastric ulcers in horses and is highly effective. Gastrozol, an enteric‐coated omeprazole formulation for horses, has recently become available, but efficacy data are controversial and sparse. Objectives To investigate the efficacy of GastroGard and Gastrozol at labeled doses (4 and 1 mg of omeprazole per kg bwt, respectively, PO q24h) in healing of gastric ulcers. Animals 40 horses; 9.5 ± 4.6 years; 491 ± 135 kg. Methods Prospective, randomized, blinded study. Horses with an ulcer score ≥1 (Equine Gastric Ulcer Council) were randomly divided into 2 groups and treated for 2 weeks each with GastroGard followed by Gastrozol (A) or vice versa (B). After 2 and 4 weeks, scoring was repeated and compared with baseline. Plasma omeprazole concentrations were measured on the first day of treatment after administration of GastroGard (n = 5) or Gastrozol (n = 5). Results Compared with baseline (squamous score (A) 1.65 ± 0.11, (B) 1.98 ± 0.11), ulcer scores at 2 weeks ((A) 0.89 ± 0.11, (B) 1.01 ± 0.11) and 4 weeks ((A) 1.10 ± 0.12, (B) 0.80 ± 0.12) had significantly decreased in both groups (P < .001), independent of treatment (P = .7). Plasma omeprazole concentrations were significantly higher after GastroGard compared with Gastrozol administration (AUCGG = 2856 (1405‐4576) ng/mL × h, AUCGZ = 604 (430‐1609) ng/mL × h; P = .03). The bioavailability for Gastrozol was 1.26 (95% CI 0.56–2.81) times higher than for GastroGard. Conclusions and Clinical Importance Both Gastrozol and GastroGard, combined with appropriate environmental changes, promote healing of gastric ulcers in horses. However, despite enteric coating of Gastrozol, plasma omeprazole concentrations after single labeled doses were significantly higher with GastroGard.https://doi.org/10.1111/jvim.12341EGUSGastroenterologyGastroGardGastrozol |
| spellingShingle | K. Birkmann H.K. Junge E. Maischberger M. Wehrli Eser C.C. Schwarzwald Efficacy of Omeprazole Powder Paste or Enteric‐Coated Formulation in Healing of Gastric Ulcers in Horses Journal of Veterinary Internal Medicine EGUS Gastroenterology GastroGard Gastrozol |
| title | Efficacy of Omeprazole Powder Paste or Enteric‐Coated Formulation in Healing of Gastric Ulcers in Horses |
| title_full | Efficacy of Omeprazole Powder Paste or Enteric‐Coated Formulation in Healing of Gastric Ulcers in Horses |
| title_fullStr | Efficacy of Omeprazole Powder Paste or Enteric‐Coated Formulation in Healing of Gastric Ulcers in Horses |
| title_full_unstemmed | Efficacy of Omeprazole Powder Paste or Enteric‐Coated Formulation in Healing of Gastric Ulcers in Horses |
| title_short | Efficacy of Omeprazole Powder Paste or Enteric‐Coated Formulation in Healing of Gastric Ulcers in Horses |
| title_sort | efficacy of omeprazole powder paste or enteric coated formulation in healing of gastric ulcers in horses |
| topic | EGUS Gastroenterology GastroGard Gastrozol |
| url | https://doi.org/10.1111/jvim.12341 |
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