Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytes
Breast milk contains constituents, such as 1,3‐dioleoyl‐2‐palmitoylglycerol (OPO), that are beneficial for infants. Herein, we hypothesized that 2‐palmitoyl glycerol (2‐PG), a derivative of OPO, is advantageous to infants' development. Gamma aminobutyric acid (GABA) is a major neurotransmitter...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.13649 |
| _version_ | 1797789181699686400 |
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| author | Misato Tsuboi Yoshitaka Nakamura Hiroshi Sakuma |
| author_facet | Misato Tsuboi Yoshitaka Nakamura Hiroshi Sakuma |
| author_sort | Misato Tsuboi |
| collection | DOAJ |
| description | Breast milk contains constituents, such as 1,3‐dioleoyl‐2‐palmitoylglycerol (OPO), that are beneficial for infants. Herein, we hypothesized that 2‐palmitoyl glycerol (2‐PG), a derivative of OPO, is advantageous to infants' development. Gamma aminobutyric acid (GABA) is a major neurotransmitter involved in neural development. Although GABA is generally known to be produced in neurons, astrocytes can also produce it in immature brains. In this study, we used expression analysis techniques to show that 2‐PG upregulates the mRNA and protein expression of glutamate decarboxylases (GAD1 and GAD2) in normal human fetal‐derived astrocytes. Our data suggest that 2‐PG promotes GABA synthesis in astrocytes, which may contribute to brain development because GABA is involved in neural development in the developing brain. This may help to elucidate the mechanism by which breast milk affects infant brain development. |
| first_indexed | 2024-03-13T01:47:04Z |
| format | Article |
| id | doaj.art-e6c4e202525f4a6283891b054c7597cb |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-03-13T01:47:04Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-e6c4e202525f4a6283891b054c7597cb2023-07-03T07:24:35ZengWileyFEBS Open Bio2211-54632023-07-011371320133210.1002/2211-5463.13649Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytesMisato Tsuboi0Yoshitaka Nakamura1Hiroshi Sakuma2Food Microbiology and Function Research Laboratories, R&D Division Meiji Co., Ltd. Tokyo JapanFood Microbiology and Function Research Laboratories, R&D Division Meiji Co., Ltd. Tokyo JapanDepartment of Pediatric Neurology Niigata University Graduate School of Medical and Dental Sciences JapanBreast milk contains constituents, such as 1,3‐dioleoyl‐2‐palmitoylglycerol (OPO), that are beneficial for infants. Herein, we hypothesized that 2‐palmitoyl glycerol (2‐PG), a derivative of OPO, is advantageous to infants' development. Gamma aminobutyric acid (GABA) is a major neurotransmitter involved in neural development. Although GABA is generally known to be produced in neurons, astrocytes can also produce it in immature brains. In this study, we used expression analysis techniques to show that 2‐PG upregulates the mRNA and protein expression of glutamate decarboxylases (GAD1 and GAD2) in normal human fetal‐derived astrocytes. Our data suggest that 2‐PG promotes GABA synthesis in astrocytes, which may contribute to brain development because GABA is involved in neural development in the developing brain. This may help to elucidate the mechanism by which breast milk affects infant brain development.https://doi.org/10.1002/2211-5463.136491,3‐dioleoyl‐2‐palmitoylglycerolastrocytesbrain developmentbreast milkgamma aminobutyric acid metabolism |
| spellingShingle | Misato Tsuboi Yoshitaka Nakamura Hiroshi Sakuma Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytes FEBS Open Bio 1,3‐dioleoyl‐2‐palmitoylglycerol astrocytes brain development breast milk gamma aminobutyric acid metabolism |
| title | Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytes |
| title_full | Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytes |
| title_fullStr | Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytes |
| title_full_unstemmed | Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytes |
| title_short | Direct effect of 2‐palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal‐derived astrocytes |
| title_sort | direct effect of 2 palmitoyl glycerol on promotion of gamma aminobutyric acid synthesis in normal human fetal derived astrocytes |
| topic | 1,3‐dioleoyl‐2‐palmitoylglycerol astrocytes brain development breast milk gamma aminobutyric acid metabolism |
| url | https://doi.org/10.1002/2211-5463.13649 |
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