Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac Adenocarcinoma
Apocrine gland anal sac adenocarcinoma (AGASACA) is locally aggressive and highly metastatic to regional lymph nodes. The aim of this study was to evaluate the prognostic significance of Ki67 in surgically excised AGASACA. Prognostic impact of size, regional lymph nodes metastasis, hypercalcemia, hi...
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MDPI AG
2021-06-01
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| author | Emanuela Maria Morello Marzia Cino Davide Giacobino Arturo Nicoletti Selina Iussich Paolo Buracco Marina Martano |
| author_facet | Emanuela Maria Morello Marzia Cino Davide Giacobino Arturo Nicoletti Selina Iussich Paolo Buracco Marina Martano |
| author_sort | Emanuela Maria Morello |
| collection | DOAJ |
| description | Apocrine gland anal sac adenocarcinoma (AGASACA) is locally aggressive and highly metastatic to regional lymph nodes. The aim of this study was to evaluate the prognostic significance of Ki67 in surgically excised AGASACA. Prognostic impact of size, regional lymph nodes metastasis, hypercalcemia, histologic pattern, mitotic count, necrosis, inflammatory and lympho-vascular invasion, anisokaryosis and anisocytosis was also evaluated. Thirty-five dogs were included, twenty-four of which also had metastatic lymph nodes. When the entire population was evaluated, only metastatic disease spread to regional lymph nodes, and necrosis and inflammatory infiltration were correlated to prognosis. When only dogs with metastatic disease were evaluated, size, solid histologic pattern, presence of lymphatic and vascular invasion showed influence on prognosis. Ki67 index was not associated with survival time and disease free interval in any case. The results of this study showed that lymph nodes metastasis at diagnosis reduced disease free interval. Moreover, tumor size greater than 5.25 cm, presence of lymphatic and vascular invasion and a solid histologic pattern were associated with a shorter survival time in dogs with metastasis to regional lymph nodes. Ki67 expression was not significantly associated with prognosis, therefore it could not be considered as a prognostic factor in this tumor type, while the role of hypercalcemia remained unclear. |
| first_indexed | 2024-03-10T10:48:15Z |
| format | Article |
| id | doaj.art-e6c4ed7860804a7bbda597837b17072c |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T10:48:15Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-e6c4ed7860804a7bbda597837b17072c2023-11-21T22:29:26ZengMDPI AGAnimals2076-26152021-06-01116164910.3390/ani11061649Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac AdenocarcinomaEmanuela Maria Morello0Marzia Cino1Davide Giacobino2Arturo Nicoletti3Selina Iussich4Paolo Buracco5Marina Martano6Department of Veterinary Sciences, University of Torino, Largo Braccini 2, 10095 Grugliasco, ItalyDepartment of Medical-Veterinary Science, Univesrity of Parma, Strada del Taglio 10, 43126 Parma, ItalyDepartment of Veterinary Sciences, University of Torino, Largo Braccini 2, 10095 Grugliasco, ItalyDepartment of Veterinary Sciences, University of Torino, Largo Braccini 2, 10095 Grugliasco, ItalyDepartment of Veterinary Sciences, University of Torino, Largo Braccini 2, 10095 Grugliasco, ItalyDepartment of Veterinary Sciences, University of Torino, Largo Braccini 2, 10095 Grugliasco, ItalyDepartment of Medical-Veterinary Science, Univesrity of Parma, Strada del Taglio 10, 43126 Parma, ItalyApocrine gland anal sac adenocarcinoma (AGASACA) is locally aggressive and highly metastatic to regional lymph nodes. The aim of this study was to evaluate the prognostic significance of Ki67 in surgically excised AGASACA. Prognostic impact of size, regional lymph nodes metastasis, hypercalcemia, histologic pattern, mitotic count, necrosis, inflammatory and lympho-vascular invasion, anisokaryosis and anisocytosis was also evaluated. Thirty-five dogs were included, twenty-four of which also had metastatic lymph nodes. When the entire population was evaluated, only metastatic disease spread to regional lymph nodes, and necrosis and inflammatory infiltration were correlated to prognosis. When only dogs with metastatic disease were evaluated, size, solid histologic pattern, presence of lymphatic and vascular invasion showed influence on prognosis. Ki67 index was not associated with survival time and disease free interval in any case. The results of this study showed that lymph nodes metastasis at diagnosis reduced disease free interval. Moreover, tumor size greater than 5.25 cm, presence of lymphatic and vascular invasion and a solid histologic pattern were associated with a shorter survival time in dogs with metastasis to regional lymph nodes. Ki67 expression was not significantly associated with prognosis, therefore it could not be considered as a prognostic factor in this tumor type, while the role of hypercalcemia remained unclear.https://www.mdpi.com/2076-2615/11/6/1649doganal sac adenocarcinomaAGASACAKi67prognosis |
| spellingShingle | Emanuela Maria Morello Marzia Cino Davide Giacobino Arturo Nicoletti Selina Iussich Paolo Buracco Marina Martano Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac Adenocarcinoma Animals dog anal sac adenocarcinoma AGASACA Ki67 prognosis |
| title | Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac Adenocarcinoma |
| title_full | Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac Adenocarcinoma |
| title_fullStr | Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac Adenocarcinoma |
| title_full_unstemmed | Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac Adenocarcinoma |
| title_short | Prognostic Value of Ki67 and Other Clinical and Histopathological Factors in Canine Apocrine Gland Anal Sac Adenocarcinoma |
| title_sort | prognostic value of ki67 and other clinical and histopathological factors in canine apocrine gland anal sac adenocarcinoma |
| topic | dog anal sac adenocarcinoma AGASACA Ki67 prognosis |
| url | https://www.mdpi.com/2076-2615/11/6/1649 |
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