Identification of Tight-Binding Plasmepsin II and Falcipain 2 Inhibitors in Aqueous Extracts of Marine Invertebrates by the Combination of Enzymatic and Interaction-Based Assays

Identification of Tight-Binding Plasmepsin II and Falcipain 2 Inhibitors in Aqueous Extracts of Marine Invertebrates by the Combination of Enzymatic and Interaction-Based Assays

Natural products from marine origin constitute a very promising and underexplored source of interesting compounds for modern biotechnological and pharmaceutical industries. However, their evaluation is quite challenging and requires specifically designed assays to reliably identify the compounds of...

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Bibliographic Details
Main Authors: Emir Salas-Sarduy, Yasel Guerra, Giovanni Covaleda Cortés, Francesc Xavier Avilés, María A. Chávez Planes
Format: Article
Language:English
Published: MDPI AG 2017-04-01
Series:Marine Drugs
Subjects:
tight-binding protease inhibitor
combined screening strategy
Plasmepsin II
Falcipain 2
Plasmodium falciparum
Online Access:http://www.mdpi.com/1660-3397/15/4/123

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