Dynamic oxygenator blood volume during prolonged extracorporeal life support.
Current methods for identification of oxygenator clotting during prolonged extracorporeal life support include visual inspection, evaluation of oxygenator resistance and oxygen exchange performance, and assessment of clotting-related laboratory parameters. However, these observations do not provide...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0263360 |
| _version_ | 1818987961457311744 |
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| author | Rik H J Hendrix Eva R Kurniawati Sanne F C Schins Jos G Maessen Patrick W Weerwind |
| author_facet | Rik H J Hendrix Eva R Kurniawati Sanne F C Schins Jos G Maessen Patrick W Weerwind |
| author_sort | Rik H J Hendrix |
| collection | DOAJ |
| description | Current methods for identification of oxygenator clotting during prolonged extracorporeal life support include visual inspection, evaluation of oxygenator resistance and oxygen exchange performance, and assessment of clotting-related laboratory parameters. However, these observations do not provide a quantitative assessment of oxygenator clot formation. By measuring changes in the dynamic oxygenator blood volume this study aimed to evaluate the relation to oxygenator resistance and oxygen transfer performance. Sixty-seven oxygenators were studied during adult extracorporeal life support. Oxygenator blood volume, oxygenator resistance, and oxygen transfer efficiency were monitored. Oxygenator blood volume decreased with increasing runtime (r = -0.462; p <0.001). There was a statistically significant, fair negative correlation between oxygenator blood volume and oxygenator resistance (r = -0.476; p<0.001) in all oxygenators, which became stronger analyzing only exchanged oxygenators (r = -0.680; p<0.001) and oxygenators with an oxygenator blood volume <187 mL (r = 0.831; p<0.001). No relevant correlation between oxygenator blood volume and O2 transfer was found. Oxygenator blood volume declined over time and was clearly associated with an increasing oxygenator resistance during prolonged extracorporeal life support, though O2 transfer was less affected. |
| first_indexed | 2024-12-20T19:15:00Z |
| format | Article |
| id | doaj.art-e6c7cd18e21143bf8df178055ce5e507 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T19:15:00Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e6c7cd18e21143bf8df178055ce5e5072022-12-21T19:29:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01172e026336010.1371/journal.pone.0263360Dynamic oxygenator blood volume during prolonged extracorporeal life support.Rik H J HendrixEva R KurniawatiSanne F C SchinsJos G MaessenPatrick W WeerwindCurrent methods for identification of oxygenator clotting during prolonged extracorporeal life support include visual inspection, evaluation of oxygenator resistance and oxygen exchange performance, and assessment of clotting-related laboratory parameters. However, these observations do not provide a quantitative assessment of oxygenator clot formation. By measuring changes in the dynamic oxygenator blood volume this study aimed to evaluate the relation to oxygenator resistance and oxygen transfer performance. Sixty-seven oxygenators were studied during adult extracorporeal life support. Oxygenator blood volume, oxygenator resistance, and oxygen transfer efficiency were monitored. Oxygenator blood volume decreased with increasing runtime (r = -0.462; p <0.001). There was a statistically significant, fair negative correlation between oxygenator blood volume and oxygenator resistance (r = -0.476; p<0.001) in all oxygenators, which became stronger analyzing only exchanged oxygenators (r = -0.680; p<0.001) and oxygenators with an oxygenator blood volume <187 mL (r = 0.831; p<0.001). No relevant correlation between oxygenator blood volume and O2 transfer was found. Oxygenator blood volume declined over time and was clearly associated with an increasing oxygenator resistance during prolonged extracorporeal life support, though O2 transfer was less affected.https://doi.org/10.1371/journal.pone.0263360 |
| spellingShingle | Rik H J Hendrix Eva R Kurniawati Sanne F C Schins Jos G Maessen Patrick W Weerwind Dynamic oxygenator blood volume during prolonged extracorporeal life support. PLoS ONE |
| title | Dynamic oxygenator blood volume during prolonged extracorporeal life support. |
| title_full | Dynamic oxygenator blood volume during prolonged extracorporeal life support. |
| title_fullStr | Dynamic oxygenator blood volume during prolonged extracorporeal life support. |
| title_full_unstemmed | Dynamic oxygenator blood volume during prolonged extracorporeal life support. |
| title_short | Dynamic oxygenator blood volume during prolonged extracorporeal life support. |
| title_sort | dynamic oxygenator blood volume during prolonged extracorporeal life support |
| url | https://doi.org/10.1371/journal.pone.0263360 |
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