MAPK signaling regulates the efficacy of chemoimmunotherapy

MAPK signaling regulates the efficacy of chemoimmunotherapy

Resistance to chemoimmunotherapy is a major issue for cancer care. We recently unravelled the role of mitogen-activated protein kinase (MAPK) to limit the antitumor efficacy of such combination. Inhibitor of MAPK pathway using mitogen-activated protein kinase (MEK) inhibitor in combination with chem...

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Bibliographic Details
Main Author: François Ghiringhelli
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Molecular & Cellular Oncology
Subjects:
lung cancer
mek inhibitor
chemotherapy
immunotherapy
mitophagy
tlr9
immunogenic cell death
cxcl10
Online Access:http://dx.doi.org/10.1080/23723556.2022.2054652

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