Prognostic Role of Red Cell Distribution Width and Other Routine Clinico-Pathological Parameters in Dogs with Acute Pancreatitis
This study aimed to assess the prognostic value of red cell distribution width (RDW) RDW-to-calcium ratio (RDW/Ca), neutrophils-to-lymphocytes ratio (N/L), platelets-to-lymphocytes ratio (P/L) and other easy to obtain and inexpensive hematological and biochemical parameters in dogs with acute pancre...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/24/3483 |
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| author | Carlo Guglielmini Paolo Emidio Crisi Antonio Maria Tardo Roberta Di Maggio Barbara Contiero Andrea Boari Federico Fracassi Arianna Miglio |
| author_facet | Carlo Guglielmini Paolo Emidio Crisi Antonio Maria Tardo Roberta Di Maggio Barbara Contiero Andrea Boari Federico Fracassi Arianna Miglio |
| author_sort | Carlo Guglielmini |
| collection | DOAJ |
| description | This study aimed to assess the prognostic value of red cell distribution width (RDW) RDW-to-calcium ratio (RDW/Ca), neutrophils-to-lymphocytes ratio (N/L), platelets-to-lymphocytes ratio (P/L) and other easy to obtain and inexpensive hematological and biochemical parameters in dogs with acute pancreatitis. This is a multicenter, retrospective cohort study including 70 client-owned dogs. The accuracy of clinical and laboratory variables to predict short-term death (i.e., dead by 14 days) was tested by calculating the area under the receiver-operating characteristic curve (AUC). Independent predictors of death were identified using the multivariable Cox proportional hazards regression model. The survival rate was 72.9% (51 dogs) and 19 dogs died within 14 days of admission from AP. RDW and blood urea nitrogen (BUN) had good accuracy to predict short-term dead with AUC of 0.74 and 0.70 at the cut-off of >12.7% and >42 mg/dL, respectively. According to the multivariable model, RDW (hazard ratio and 95% confidence interval [HR, 95% CI] = 5.08, 95% CI = 1.14–22.67; <i>p</i> = 0.03), BUN (HR = 1.00, 95% CI = 1.00–1.01; <i>p</i> < 0.01) and bilirubin (HR = 2.46, 95% CI = 1.38–4.39; <i>p</i> < 0.01) were independent predictors of death. The results indicate that RDW, BUN and bilirubin are useful predictors of short-term death in dogs with acute pancreatitis. |
| first_indexed | 2024-03-09T17:25:28Z |
| format | Article |
| id | doaj.art-e6c8c37cfc7141c5a336f418b8ee2f6c |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T17:25:28Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-e6c8c37cfc7141c5a336f418b8ee2f6c2023-11-24T12:50:30ZengMDPI AGAnimals2076-26152022-12-011224348310.3390/ani12243483Prognostic Role of Red Cell Distribution Width and Other Routine Clinico-Pathological Parameters in Dogs with Acute PancreatitisCarlo Guglielmini0Paolo Emidio Crisi1Antonio Maria Tardo2Roberta Di Maggio3Barbara Contiero4Andrea Boari5Federico Fracassi6Arianna Miglio7Department of Animal Medicine, Production and Health, University of Padua, Viale dell’Università 16, 35020 Padova, ItalyDepartment of Veterinary Medicine, University of Teramo, Piano d’Accio, 64100 Teramo, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, ItalyDepartment of Animal Medicine, Production and Health, University of Padua, Viale dell’Università 16, 35020 Padova, ItalyDepartment of Animal Medicine, Production and Health, University of Padua, Viale dell’Università 16, 35020 Padova, ItalyDepartment of Veterinary Medicine, University of Teramo, Piano d’Accio, 64100 Teramo, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, ItalyDepartment of Veterinary Medicine, University of Teramo, Piano d’Accio, 64100 Teramo, ItalyThis study aimed to assess the prognostic value of red cell distribution width (RDW) RDW-to-calcium ratio (RDW/Ca), neutrophils-to-lymphocytes ratio (N/L), platelets-to-lymphocytes ratio (P/L) and other easy to obtain and inexpensive hematological and biochemical parameters in dogs with acute pancreatitis. This is a multicenter, retrospective cohort study including 70 client-owned dogs. The accuracy of clinical and laboratory variables to predict short-term death (i.e., dead by 14 days) was tested by calculating the area under the receiver-operating characteristic curve (AUC). Independent predictors of death were identified using the multivariable Cox proportional hazards regression model. The survival rate was 72.9% (51 dogs) and 19 dogs died within 14 days of admission from AP. RDW and blood urea nitrogen (BUN) had good accuracy to predict short-term dead with AUC of 0.74 and 0.70 at the cut-off of >12.7% and >42 mg/dL, respectively. According to the multivariable model, RDW (hazard ratio and 95% confidence interval [HR, 95% CI] = 5.08, 95% CI = 1.14–22.67; <i>p</i> = 0.03), BUN (HR = 1.00, 95% CI = 1.00–1.01; <i>p</i> < 0.01) and bilirubin (HR = 2.46, 95% CI = 1.38–4.39; <i>p</i> < 0.01) were independent predictors of death. The results indicate that RDW, BUN and bilirubin are useful predictors of short-term death in dogs with acute pancreatitis.https://www.mdpi.com/2076-2615/12/24/3483caninelaboratory biomarkeracute pancreatitisoutcomeRDWRDW-to-total calcium ratio |
| spellingShingle | Carlo Guglielmini Paolo Emidio Crisi Antonio Maria Tardo Roberta Di Maggio Barbara Contiero Andrea Boari Federico Fracassi Arianna Miglio Prognostic Role of Red Cell Distribution Width and Other Routine Clinico-Pathological Parameters in Dogs with Acute Pancreatitis Animals canine laboratory biomarker acute pancreatitis outcome RDW RDW-to-total calcium ratio |
| title | Prognostic Role of Red Cell Distribution Width and Other Routine Clinico-Pathological Parameters in Dogs with Acute Pancreatitis |
| title_full | Prognostic Role of Red Cell Distribution Width and Other Routine Clinico-Pathological Parameters in Dogs with Acute Pancreatitis |
| title_fullStr | Prognostic Role of Red Cell Distribution Width and Other Routine Clinico-Pathological Parameters in Dogs with Acute Pancreatitis |
| title_full_unstemmed | Prognostic Role of Red Cell Distribution Width and Other Routine Clinico-Pathological Parameters in Dogs with Acute Pancreatitis |
| title_short | Prognostic Role of Red Cell Distribution Width and Other Routine Clinico-Pathological Parameters in Dogs with Acute Pancreatitis |
| title_sort | prognostic role of red cell distribution width and other routine clinico pathological parameters in dogs with acute pancreatitis |
| topic | canine laboratory biomarker acute pancreatitis outcome RDW RDW-to-total calcium ratio |
| url | https://www.mdpi.com/2076-2615/12/24/3483 |
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