Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties
Oxidative stress and inflammation triggered by increased oxidative stress are the cause of many chronic diseases. The lack of anti-inflammatory drugs without side-effects has stimulated the search for new active substances. Plant-derived compounds provide new potential anti-inflammatory and antioxid...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/7/1044 |
| _version_ | 1797528428617924608 |
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| author | Monica Bucciantini Manuela Leri Pamela Nardiello Fiorella Casamenti Massimo Stefani |
| author_facet | Monica Bucciantini Manuela Leri Pamela Nardiello Fiorella Casamenti Massimo Stefani |
| author_sort | Monica Bucciantini |
| collection | DOAJ |
| description | Oxidative stress and inflammation triggered by increased oxidative stress are the cause of many chronic diseases. The lack of anti-inflammatory drugs without side-effects has stimulated the search for new active substances. Plant-derived compounds provide new potential anti-inflammatory and antioxidant molecules. Natural products are structurally optimized by evolution to serve particular biological functions, including the regulation of endogenous defense mechanisms and interaction with other organisms. This property explains their relevance for infectious diseases and cancer. Recently, among the various natural substances, polyphenols from extra virgin olive oil (EVOO), an important element of the Mediterranean diet, have aroused growing interest. Extensive studies have shown the potent therapeutic effects of these bioactive molecules against a series of chronic diseases, such as cardiovascular diseases, diabetes, neurodegenerative disorders and cancer. This review begins from the chemical structure, abundance and bioavailability of the main EVOO polyphenols to highlight the effects and the possible molecular mechanism(s) of action of these compounds against inflammation and oxidation, in vitro and in vivo. In addition, the mechanisms of inhibition of molecular signaling pathways activated by oxidative stress by EVOO polyphenols are discussed, together with their possible roles in inflammation-mediated chronic disorders, also taking into account meta-analysis of population studies and clinical trials. |
| first_indexed | 2024-03-10T09:58:12Z |
| format | Article |
| id | doaj.art-e6c9470bd96040cdbc989c177be54e83 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T09:58:12Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e6c9470bd96040cdbc989c177be54e832023-11-22T02:09:44ZengMDPI AGAntioxidants2076-39212021-06-01107104410.3390/antiox10071044Olive Polyphenols: Antioxidant and Anti-Inflammatory PropertiesMonica Bucciantini0Manuela Leri1Pamela Nardiello2Fiorella Casamenti3Massimo Stefani4Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50134, ItalyDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50134, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence 50134, ItalyDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence 50134, ItalyDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence 50134, ItalyOxidative stress and inflammation triggered by increased oxidative stress are the cause of many chronic diseases. The lack of anti-inflammatory drugs without side-effects has stimulated the search for new active substances. Plant-derived compounds provide new potential anti-inflammatory and antioxidant molecules. Natural products are structurally optimized by evolution to serve particular biological functions, including the regulation of endogenous defense mechanisms and interaction with other organisms. This property explains their relevance for infectious diseases and cancer. Recently, among the various natural substances, polyphenols from extra virgin olive oil (EVOO), an important element of the Mediterranean diet, have aroused growing interest. Extensive studies have shown the potent therapeutic effects of these bioactive molecules against a series of chronic diseases, such as cardiovascular diseases, diabetes, neurodegenerative disorders and cancer. This review begins from the chemical structure, abundance and bioavailability of the main EVOO polyphenols to highlight the effects and the possible molecular mechanism(s) of action of these compounds against inflammation and oxidation, in vitro and in vivo. In addition, the mechanisms of inhibition of molecular signaling pathways activated by oxidative stress by EVOO polyphenols are discussed, together with their possible roles in inflammation-mediated chronic disorders, also taking into account meta-analysis of population studies and clinical trials.https://www.mdpi.com/2076-3921/10/7/1044EVOO polyphenolsoxidative stressinflammation |
| spellingShingle | Monica Bucciantini Manuela Leri Pamela Nardiello Fiorella Casamenti Massimo Stefani Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties Antioxidants EVOO polyphenols oxidative stress inflammation |
| title | Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties |
| title_full | Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties |
| title_fullStr | Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties |
| title_full_unstemmed | Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties |
| title_short | Olive Polyphenols: Antioxidant and Anti-Inflammatory Properties |
| title_sort | olive polyphenols antioxidant and anti inflammatory properties |
| topic | EVOO polyphenols oxidative stress inflammation |
| url | https://www.mdpi.com/2076-3921/10/7/1044 |
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