The Levels of Apolipoproteins A1 and B in the Blood Serum and Their Ratio in Young Adults with Growth Hormone Deficiency in the Dynamics of Recombinant Growth Hormone Therapy
Aim of the investigation — to study serum levels of apolipoprotein A1 and B and their ratio in 174 young adults (average age — 22.47 ± 0.30 years) with childhood-onset growth hormone deficiency. Materials and methods. The study involved 174 patients (124 males) aged 19 to 34 years. The follow-up per...
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| Format: | Article |
| Language: | English |
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Zaslavsky O.Yu.
2016-08-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
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| Online Access: | http://iej.zaslavsky.com.ua/article/view/78752 |
| _version_ | 1818974126916763648 |
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| author | O.V. Bolshova T.O. Tkachova O.A. Vyshnevska T.M. Malynovska |
| author_facet | O.V. Bolshova T.O. Tkachova O.A. Vyshnevska T.M. Malynovska |
| author_sort | O.V. Bolshova |
| collection | DOAJ |
| description | Aim of the investigation — to study serum levels of apolipoprotein A1 and B and their ratio in 174 young adults (average age — 22.47 ± 0.30 years) with childhood-onset growth hormone deficiency. Materials and methods. The study involved 174 patients (124 males) aged 19 to 34 years. The follow-up period was up to 36 months. Results. It was found that on the background of the treatment with recombinant growth hormone (rGR), there is a gradual increase in the levels of apolipoprotein A1, a decrease in apolipoprotein B levels and normalization of their ratio in most patients after 6–12 months that reduces cardiovascular risk factors in the future. Conclusions. Against the background of rGR therapy in young adults with childhood-onset growth hormone deficiency, there are significant positive changes in some parameters of the lipid profile, namely — substantial increase in apolipoprotein A1 levels, a decrease in the serum content of apolipoprotein B and apoB/apoA1 ratio. |
| first_indexed | 2024-12-20T15:35:07Z |
| format | Article |
| id | doaj.art-e6ca038e713a4de887f4389cd78b829b |
| institution | Directory Open Access Journal |
| issn | 2224-0721 2307-1427 |
| language | English |
| last_indexed | 2024-12-20T15:35:07Z |
| publishDate | 2016-08-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj.art-e6ca038e713a4de887f4389cd78b829b2022-12-21T19:35:28ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272016-08-01125.77394210.22141/2224-0721.5.77.2016.7875278752The Levels of Apolipoproteins A1 and B in the Blood Serum and Their Ratio in Young Adults with Growth Hormone Deficiency in the Dynamics of Recombinant Growth Hormone TherapyO.V. Bolshova0T.O. Tkachova1O.A. Vyshnevska2T.M. Malynovska3State Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», KyivState Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», KyivState Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», KyivState Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», KyivAim of the investigation — to study serum levels of apolipoprotein A1 and B and their ratio in 174 young adults (average age — 22.47 ± 0.30 years) with childhood-onset growth hormone deficiency. Materials and methods. The study involved 174 patients (124 males) aged 19 to 34 years. The follow-up period was up to 36 months. Results. It was found that on the background of the treatment with recombinant growth hormone (rGR), there is a gradual increase in the levels of apolipoprotein A1, a decrease in apolipoprotein B levels and normalization of their ratio in most patients after 6–12 months that reduces cardiovascular risk factors in the future. Conclusions. Against the background of rGR therapy in young adults with childhood-onset growth hormone deficiency, there are significant positive changes in some parameters of the lipid profile, namely — substantial increase in apolipoprotein A1 levels, a decrease in the serum content of apolipoprotein B and apoB/apoA1 ratio.http://iej.zaslavsky.com.ua/article/view/78752childhood-onset growth hormone deficiencyyoung adultsapolipoproteinA1apolipoprotein BаpoB/аpoA1 ratiorecombinant growth hormone treatment |
| spellingShingle | O.V. Bolshova T.O. Tkachova O.A. Vyshnevska T.M. Malynovska The Levels of Apolipoproteins A1 and B in the Blood Serum and Their Ratio in Young Adults with Growth Hormone Deficiency in the Dynamics of Recombinant Growth Hormone Therapy Mìžnarodnij Endokrinologìčnij Žurnal childhood-onset growth hormone deficiency young adults apolipoproteinA1 apolipoprotein B аpoB/аpoA1 ratio recombinant growth hormone treatment |
| title | The Levels of Apolipoproteins A1 and B in the Blood Serum and Their Ratio in Young Adults with Growth Hormone Deficiency in the Dynamics of Recombinant Growth Hormone Therapy |
| title_full | The Levels of Apolipoproteins A1 and B in the Blood Serum and Their Ratio in Young Adults with Growth Hormone Deficiency in the Dynamics of Recombinant Growth Hormone Therapy |
| title_fullStr | The Levels of Apolipoproteins A1 and B in the Blood Serum and Their Ratio in Young Adults with Growth Hormone Deficiency in the Dynamics of Recombinant Growth Hormone Therapy |
| title_full_unstemmed | The Levels of Apolipoproteins A1 and B in the Blood Serum and Their Ratio in Young Adults with Growth Hormone Deficiency in the Dynamics of Recombinant Growth Hormone Therapy |
| title_short | The Levels of Apolipoproteins A1 and B in the Blood Serum and Their Ratio in Young Adults with Growth Hormone Deficiency in the Dynamics of Recombinant Growth Hormone Therapy |
| title_sort | levels of apolipoproteins a1 and b in the blood serum and their ratio in young adults with growth hormone deficiency in the dynamics of recombinant growth hormone therapy |
| topic | childhood-onset growth hormone deficiency young adults apolipoproteinA1 apolipoprotein B аpoB/аpoA1 ratio recombinant growth hormone treatment |
| url | http://iej.zaslavsky.com.ua/article/view/78752 |
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