Neutrophils as potential therapeutic targets for breast cancer
Breast cancer (BC) remains the foremost cause of cancer mortality globally, with neutrophils playing a critical role in its pathogenesis. As an essential tumor microenvironment (TME) component, neutrophils are emerging as pivotal factors in BC progression. Growing evidence has proved that neutrophil...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661823003523 |
| _version_ | 1827609667281354752 |
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| author | Yi-Ting Gong Li-Jun Zhang Yi-Chen Liu Min Tang Jia-Yi Lin Xin-Yi Chen Yi-Xu Chen Yue Yan Wei-Dong Zhang Jin-Mei Jin Xin Luan |
| author_facet | Yi-Ting Gong Li-Jun Zhang Yi-Chen Liu Min Tang Jia-Yi Lin Xin-Yi Chen Yi-Xu Chen Yue Yan Wei-Dong Zhang Jin-Mei Jin Xin Luan |
| author_sort | Yi-Ting Gong |
| collection | DOAJ |
| description | Breast cancer (BC) remains the foremost cause of cancer mortality globally, with neutrophils playing a critical role in its pathogenesis. As an essential tumor microenvironment (TME) component, neutrophils are emerging as pivotal factors in BC progression. Growing evidence has proved that neutrophils play a Janus- role in BC by polarizing into the anti-tumor (N1) or pro-tumor (N2) phenotype. Clinical trials are evaluating neutrophil-targeted therapies, including Reparixin (NCT02370238) and Tigatuzumab (NCT01307891); however, their clinical efficacy remains suboptimal. This review summarizes the evidence regarding the close relationship between neutrophils and BC, emphasizing the critical roles of neutrophils in regulating metabolic and immune pathways. Additionally, we summarize the existing therapeutic approaches that target neutrophils, highlighting the challenges, and affirming the rationale for continuing to explore neutrophils as a viable therapeutic target in BC management. |
| first_indexed | 2024-03-09T07:36:44Z |
| format | Article |
| id | doaj.art-e6ca63030e2b49d2abfbe0d424dadfa1 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-09T07:36:44Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-e6ca63030e2b49d2abfbe0d424dadfa12023-12-03T05:39:40ZengElsevierPharmacological Research1096-11862023-12-01198106996Neutrophils as potential therapeutic targets for breast cancerYi-Ting Gong0Li-Jun Zhang1Yi-Chen Liu2Min Tang3Jia-Yi Lin4Xin-Yi Chen5Yi-Xu Chen6Yue Yan7Wei-Dong Zhang8Jin-Mei Jin9Xin Luan10Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, ChinaShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaShanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; School of Pharmacy, Second Military Medical University, Shanghai 201203, China; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China; Corresponding author at: Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Corresponding authors.Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; Corresponding authors.Breast cancer (BC) remains the foremost cause of cancer mortality globally, with neutrophils playing a critical role in its pathogenesis. As an essential tumor microenvironment (TME) component, neutrophils are emerging as pivotal factors in BC progression. Growing evidence has proved that neutrophils play a Janus- role in BC by polarizing into the anti-tumor (N1) or pro-tumor (N2) phenotype. Clinical trials are evaluating neutrophil-targeted therapies, including Reparixin (NCT02370238) and Tigatuzumab (NCT01307891); however, their clinical efficacy remains suboptimal. This review summarizes the evidence regarding the close relationship between neutrophils and BC, emphasizing the critical roles of neutrophils in regulating metabolic and immune pathways. Additionally, we summarize the existing therapeutic approaches that target neutrophils, highlighting the challenges, and affirming the rationale for continuing to explore neutrophils as a viable therapeutic target in BC management.http://www.sciencedirect.com/science/article/pii/S1043661823003523Breast cancerNeutrophilsMetabolic pathwayImmunotherapyTargeted strategies |
| spellingShingle | Yi-Ting Gong Li-Jun Zhang Yi-Chen Liu Min Tang Jia-Yi Lin Xin-Yi Chen Yi-Xu Chen Yue Yan Wei-Dong Zhang Jin-Mei Jin Xin Luan Neutrophils as potential therapeutic targets for breast cancer Pharmacological Research Breast cancer Neutrophils Metabolic pathway Immunotherapy Targeted strategies |
| title | Neutrophils as potential therapeutic targets for breast cancer |
| title_full | Neutrophils as potential therapeutic targets for breast cancer |
| title_fullStr | Neutrophils as potential therapeutic targets for breast cancer |
| title_full_unstemmed | Neutrophils as potential therapeutic targets for breast cancer |
| title_short | Neutrophils as potential therapeutic targets for breast cancer |
| title_sort | neutrophils as potential therapeutic targets for breast cancer |
| topic | Breast cancer Neutrophils Metabolic pathway Immunotherapy Targeted strategies |
| url | http://www.sciencedirect.com/science/article/pii/S1043661823003523 |
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