LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality
Aberrant DNA methylation seems to be associated with prostate cancer behavior. We investigated LINE-1 methylation in prostate cancer and non-neoplastic tissue adjacent to tumor (NTAT) in association with mortality from prostate cancer. We selected 157 prostate cancer patients with available NTAT fro...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2017-01-01
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Series: | Epigenetics |
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Online Access: | http://dx.doi.org/10.1080/15592294.2016.1261786 |
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author | Valentina Fiano Daniela Zugna Chiara Grasso Morena Trevisan Luisa Delsedime Luca Molinaro Anna Gillio-Tos Franco Merletti Lorenzo Richiardi |
author_facet | Valentina Fiano Daniela Zugna Chiara Grasso Morena Trevisan Luisa Delsedime Luca Molinaro Anna Gillio-Tos Franco Merletti Lorenzo Richiardi |
author_sort | Valentina Fiano |
collection | DOAJ |
description | Aberrant DNA methylation seems to be associated with prostate cancer behavior. We investigated LINE-1 methylation in prostate cancer and non-neoplastic tissue adjacent to tumor (NTAT) in association with mortality from prostate cancer. We selected 157 prostate cancer patients with available NTAT from 2 cohorts of patients diagnosed between 1982–1988 and 1993–1996, followed up until 2010. An association between LINE-1 hypomethylation and prostate cancer mortality in tumor was suggested [hazard ratio per 5% decrease in LINE-1 methylation levels: 1.40, 95% confidence interval (CI): 0.95–2.01]. After stratification of the patients for Gleason score, the association was present only for those with a Gleason score of at least 8. Among these, low (<75%) vs. high (>80%) LINE-1 methylation was associated with a hazard ratio of 4.68 (95% CI: 1.03–21.34). LINE-1 methylation in the NTAT was not associated with prostate cancer mortality. Our results are consistent with the hypothesis that tumor tissue global hypomethylation may be a late event in prostate cancerogenesis and is associated with tumor progression. |
first_indexed | 2024-03-11T23:07:54Z |
format | Article |
id | doaj.art-e6cd3aa87c904b1a82795ea38f65de97 |
institution | Directory Open Access Journal |
issn | 1559-2294 1559-2308 |
language | English |
last_indexed | 2024-03-11T23:07:54Z |
publishDate | 2017-01-01 |
publisher | Taylor & Francis Group |
record_format | Article |
series | Epigenetics |
spelling | doaj.art-e6cd3aa87c904b1a82795ea38f65de972023-09-21T12:43:12ZengTaylor & Francis GroupEpigenetics1559-22941559-23082017-01-01121111810.1080/15592294.2016.12617861261786LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortalityValentina Fiano0Daniela Zugna1Chiara Grasso2Morena Trevisan3Luisa Delsedime4Luca Molinaro5Anna Gillio-Tos6Franco Merletti7Lorenzo Richiardi8Cancer Epidemiology Unit-CERMSCancer Epidemiology Unit-CERMSCancer Epidemiology Unit-CERMSCancer Epidemiology Unit-CERMSDivision of Pathology, A.O. Città della Salute e della Scienza HospitalDivision of Pathology, A.O. Città della Salute e della Scienza HospitalCancer Epidemiology Unit-CERMSCancer Epidemiology Unit-CERMSCancer Epidemiology Unit-CERMSAberrant DNA methylation seems to be associated with prostate cancer behavior. We investigated LINE-1 methylation in prostate cancer and non-neoplastic tissue adjacent to tumor (NTAT) in association with mortality from prostate cancer. We selected 157 prostate cancer patients with available NTAT from 2 cohorts of patients diagnosed between 1982–1988 and 1993–1996, followed up until 2010. An association between LINE-1 hypomethylation and prostate cancer mortality in tumor was suggested [hazard ratio per 5% decrease in LINE-1 methylation levels: 1.40, 95% confidence interval (CI): 0.95–2.01]. After stratification of the patients for Gleason score, the association was present only for those with a Gleason score of at least 8. Among these, low (<75%) vs. high (>80%) LINE-1 methylation was associated with a hazard ratio of 4.68 (95% CI: 1.03–21.34). LINE-1 methylation in the NTAT was not associated with prostate cancer mortality. Our results are consistent with the hypothesis that tumor tissue global hypomethylation may be a late event in prostate cancerogenesis and is associated with tumor progression.http://dx.doi.org/10.1080/15592294.2016.1261786global hypomethylationline-1mortalitymethylationnon-neoplastic tissueprostate cancer |
spellingShingle | Valentina Fiano Daniela Zugna Chiara Grasso Morena Trevisan Luisa Delsedime Luca Molinaro Anna Gillio-Tos Franco Merletti Lorenzo Richiardi LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality Epigenetics global hypomethylation line-1 mortality methylation non-neoplastic tissue prostate cancer |
title | LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality |
title_full | LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality |
title_fullStr | LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality |
title_full_unstemmed | LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality |
title_short | LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality |
title_sort | line 1 methylation status in prostate cancer and non neoplastic tissue adjacent to tumor in association with mortality |
topic | global hypomethylation line-1 mortality methylation non-neoplastic tissue prostate cancer |
url | http://dx.doi.org/10.1080/15592294.2016.1261786 |
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