Oestrogen Activates the MAP3K1 Cascade and β-Catenin to Promote Granulosa-like Cell Fate in a Human Testis-Derived Cell Line

Oestrogen Activates the MAP3K1 Cascade and β-Catenin to Promote Granulosa-like Cell Fate in a Human Testis-Derived Cell Line

Sex determination triggers the differentiation of the bi-potential gonad into either an ovary or testis. In non-mammalian vertebrates, the presence or absence of oestrogen dictates gonad differentiation, while in mammals, this mechanism has been supplanted by the testis-determining gene <i>SRY...

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Bibliographic Details
Main Authors: Melanie K. Stewart, Pascal Bernard, Ching-Seng Ang, Deidre M. Mattiske, Andrew J. Pask
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
oestrogen
SOX9
β-catenin
MAP3K1
gonad differentiation
Online Access:https://www.mdpi.com/1422-0067/22/18/10046

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