The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein

The inherent flexibility of receptor binding domains in SARS-CoV-2 spike protein

Spike (S) protein is the primary antigenic target for neutralization and vaccine development for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It decorates the virus surface and undergoes large motions of its receptor binding domains (RBDs) to enter the host cell. Here, we observ...

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Bibliographic Details
Main Authors: Hisham M Dokainish, Suyong Re, Takaharu Mori, Chigusa Kobayashi, Jaewoon Jung, Yuji Sugita
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
SARS-CoV-2
spike protein
conformational transition
cryptic pockets
enhanced sampling
Online Access:https://elifesciences.org/articles/75720

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