<i>Cannabis sativa</i> CBD Extract Shows Promising Antibacterial Activity against <i>Salmonella typhimurium</i> and <i>S. newington</i>
Products derived from <i>Cannabis sativa</i> L. have gained increased interest and popularity. As these products become common amongst the public, the health and potential therapeutic values associated with hemp have become a premier focus of research. While the psychoactive and medicina...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/9/2669 |
| _version_ | 1827672108512051200 |
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| author | Logan Gildea Joseph Atia Ayariga Olufemi S. Ajayi Junhuan Xu Robert Villafane Michelle Samuel-Foo |
| author_facet | Logan Gildea Joseph Atia Ayariga Olufemi S. Ajayi Junhuan Xu Robert Villafane Michelle Samuel-Foo |
| author_sort | Logan Gildea |
| collection | DOAJ |
| description | Products derived from <i>Cannabis sativa</i> L. have gained increased interest and popularity. As these products become common amongst the public, the health and potential therapeutic values associated with hemp have become a premier focus of research. While the psychoactive and medicinal properties of <i>Cannabis</i> products have been extensively highlighted in the literature, the antibacterial properties of cannabidiol (CBD) have not been explored in depth. This research serves to examine the antibacterial potential of CBD against <i>Salmonella newington</i> and <i>S</i>. <i>typhimurium</i>. In this study, we observed bacterial response to CBD exposure through biological assays, bacterial kinetics, and fluorescence microscopy. Additionally, comparative studies between CBD and ampicillin were conducted against <i>S</i>. <i>typhimurium</i> and <i>S</i>. <i>newington</i> to determine comparative efficacy. Furthermore, we observed potential resistance development of our <i>Salmonella</i> spp. against CBD treatment. |
| first_indexed | 2024-03-10T03:55:08Z |
| format | Article |
| id | doaj.art-e6d425e106fa40b789c9c26c46a527af |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:55:08Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e6d425e106fa40b789c9c26c46a527af2023-11-23T08:47:51ZengMDPI AGMolecules1420-30492022-04-01279266910.3390/molecules27092669<i>Cannabis sativa</i> CBD Extract Shows Promising Antibacterial Activity against <i>Salmonella typhimurium</i> and <i>S. newington</i>Logan Gildea0Joseph Atia Ayariga1Olufemi S. Ajayi2Junhuan Xu3Robert Villafane4Michelle Samuel-Foo5The Microbiology Program, College of Science, Technology, Engineering, and Mathematics (C-STEM), Alabama State University, Montgomery, AL 36104, USAThe Biomedical Engineering Program, College of Science, Technology, Engineering, and Mathematics (C-STEM), Alabama State University, Montgomery, AL 36104, USADepartment of Biological Sciences, Alabama State University, Montgomery, AL 36104, USADepartment of Biological Sciences, Alabama State University, Montgomery, AL 36104, USAThe Microbiology Program, College of Science, Technology, Engineering, and Mathematics (C-STEM), Alabama State University, Montgomery, AL 36104, USADepartment of Biological Sciences, Alabama State University, Montgomery, AL 36104, USAProducts derived from <i>Cannabis sativa</i> L. have gained increased interest and popularity. As these products become common amongst the public, the health and potential therapeutic values associated with hemp have become a premier focus of research. While the psychoactive and medicinal properties of <i>Cannabis</i> products have been extensively highlighted in the literature, the antibacterial properties of cannabidiol (CBD) have not been explored in depth. This research serves to examine the antibacterial potential of CBD against <i>Salmonella newington</i> and <i>S</i>. <i>typhimurium</i>. In this study, we observed bacterial response to CBD exposure through biological assays, bacterial kinetics, and fluorescence microscopy. Additionally, comparative studies between CBD and ampicillin were conducted against <i>S</i>. <i>typhimurium</i> and <i>S</i>. <i>newington</i> to determine comparative efficacy. Furthermore, we observed potential resistance development of our <i>Salmonella</i> spp. against CBD treatment.https://www.mdpi.com/1420-3049/27/9/2669<i>Salmonella</i>novel antibacterial agentsmembrane disruptioncannabidiol |
| spellingShingle | Logan Gildea Joseph Atia Ayariga Olufemi S. Ajayi Junhuan Xu Robert Villafane Michelle Samuel-Foo <i>Cannabis sativa</i> CBD Extract Shows Promising Antibacterial Activity against <i>Salmonella typhimurium</i> and <i>S. newington</i> Molecules <i>Salmonella</i> novel antibacterial agents membrane disruption cannabidiol |
| title | <i>Cannabis sativa</i> CBD Extract Shows Promising Antibacterial Activity against <i>Salmonella typhimurium</i> and <i>S. newington</i> |
| title_full | <i>Cannabis sativa</i> CBD Extract Shows Promising Antibacterial Activity against <i>Salmonella typhimurium</i> and <i>S. newington</i> |
| title_fullStr | <i>Cannabis sativa</i> CBD Extract Shows Promising Antibacterial Activity against <i>Salmonella typhimurium</i> and <i>S. newington</i> |
| title_full_unstemmed | <i>Cannabis sativa</i> CBD Extract Shows Promising Antibacterial Activity against <i>Salmonella typhimurium</i> and <i>S. newington</i> |
| title_short | <i>Cannabis sativa</i> CBD Extract Shows Promising Antibacterial Activity against <i>Salmonella typhimurium</i> and <i>S. newington</i> |
| title_sort | i cannabis sativa i cbd extract shows promising antibacterial activity against i salmonella typhimurium i and i s newington i |
| topic | <i>Salmonella</i> novel antibacterial agents membrane disruption cannabidiol |
| url | https://www.mdpi.com/1420-3049/27/9/2669 |
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