Single Turnover of Transient of Reactants Supports a Complex Interplay of Conformational States in the Mode of Action of <i>Mycobacterium tuberculosis</i> Enoyl Reductase

Single Turnover of Transient of Reactants Supports a Complex Interplay of Conformational States in the Mode of Action of <i>Mycobacterium tuberculosis</i> Enoyl Reductase

The enoyl reductase from <i>Mycobacterium tuberculosis</i> (<i>Mt</i>InhA) was shown to be a major target for isoniazid, the most prescribed first-line anti-tuberculosis agent. The <i>Mt</i>InhA (EC 1.3.1.9) protein catalyzes the hydride transfer from the 4<i&g...

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Bibliographic Details
Main Authors: Leonardo Kras Borges Martinelli, Mariane Rotta, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Future Pharmacology
Subjects:
tuberculosis
InhA
enoyl reductase
mycolic acids
isoniazid
drug target
Online Access:https://www.mdpi.com/2673-9879/3/2/23

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