Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing Material
Nanotechnology and tissue engineering have accelerated wound healing. Polyhydroxyalkanoates, with suitable physical, biological and mechanical properties, can be considered as a good candidate in tissue repair and regeneration. In this study, nanofibrous mats of polyhydroxybutyrate (PHB) containing...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2020-03-01
|
| Series: | Nano Biomedicine and Engineering |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.5101/nbe.v12i1.p14-20 |
| _version_ | 1797673409151238144 |
|---|---|
| author | Reyhaneh Ghavami L Esmaeil Biazar Arezoo Sodagar Taleghani Saeed Heidari Keshel |
| author_facet | Reyhaneh Ghavami L Esmaeil Biazar Arezoo Sodagar Taleghani Saeed Heidari Keshel |
| author_sort | Reyhaneh Ghavami L |
| collection | DOAJ |
| description | Nanotechnology and tissue engineering have accelerated wound healing. Polyhydroxyalkanoates, with suitable physical, biological and mechanical properties, can be considered as a good candidate in tissue repair and regeneration. In this study, nanofibrous mats of polyhydroxybutyrate (PHB) containing curcumin as a wound healing agent, were designed by electrospinning method. The samples were evaluated by microscopic and mechanical analyses, cell assays and microbial tests. The results of microscopic images showed that the diameter of fibers increased with the increase in the curcumin concentration. The elongation and elasticity modulus of nanofibers increased and decreased respectively, with the increase in the amount of curcumin. Drug release study indicated that increasing the curcumin concentration into nanofibers accelerated rate of drug release. Cytotoxicity results of nanofibrous samples with lower curcumin showed better biocompatibility. The strongest antibacterial activity was shown by the sample with 3% curcumin. In addition, Curcumin-loaded nanofibrous PHB can be potential candidates for wound healing. |
| first_indexed | 2024-03-11T21:44:05Z |
| format | Article |
| id | doaj.art-e6d7c7429f5c473d9a1a9f3e6ff8f3e4 |
| institution | Directory Open Access Journal |
| issn | 2150-5578 |
| language | English |
| last_indexed | 2024-03-11T21:44:05Z |
| publishDate | 2020-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Nano Biomedicine and Engineering |
| spelling | doaj.art-e6d7c7429f5c473d9a1a9f3e6ff8f3e42023-09-26T11:03:54ZengTsinghua University PressNano Biomedicine and Engineering2150-55782020-03-01121142010.5101/nbe.v12i1.p14-20Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing MaterialReyhaneh Ghavami L0Esmaeil Biazar1Arezoo Sodagar Taleghani2Saeed Heidari Keshel3Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, IranDepartment of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, IranDepartment of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranNanotechnology and tissue engineering have accelerated wound healing. Polyhydroxyalkanoates, with suitable physical, biological and mechanical properties, can be considered as a good candidate in tissue repair and regeneration. In this study, nanofibrous mats of polyhydroxybutyrate (PHB) containing curcumin as a wound healing agent, were designed by electrospinning method. The samples were evaluated by microscopic and mechanical analyses, cell assays and microbial tests. The results of microscopic images showed that the diameter of fibers increased with the increase in the curcumin concentration. The elongation and elasticity modulus of nanofibers increased and decreased respectively, with the increase in the amount of curcumin. Drug release study indicated that increasing the curcumin concentration into nanofibers accelerated rate of drug release. Cytotoxicity results of nanofibrous samples with lower curcumin showed better biocompatibility. The strongest antibacterial activity was shown by the sample with 3% curcumin. In addition, Curcumin-loaded nanofibrous PHB can be potential candidates for wound healing.https://www.sciopen.com/article/10.5101/nbe.v12i1.p14-20controlled releasecurcumincytotoxicity studyphysical and mechanical propertiespolyhydroxybutyrate (phb) nanofiber |
| spellingShingle | Reyhaneh Ghavami L Esmaeil Biazar Arezoo Sodagar Taleghani Saeed Heidari Keshel Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing Material Nano Biomedicine and Engineering controlled release curcumin cytotoxicity study physical and mechanical properties polyhydroxybutyrate (phb) nanofiber |
| title | Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing Material |
| title_full | Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing Material |
| title_fullStr | Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing Material |
| title_full_unstemmed | Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing Material |
| title_short | Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing Material |
| title_sort | design of curcumin loaded electrospun polyhydroxybutyrate mat as a wound healing material |
| topic | controlled release curcumin cytotoxicity study physical and mechanical properties polyhydroxybutyrate (phb) nanofiber |
| url | https://www.sciopen.com/article/10.5101/nbe.v12i1.p14-20 |
| work_keys_str_mv | AT reyhanehghavamil designofcurcuminloadedelectrospunpolyhydroxybutyratematasawoundhealingmaterial AT esmaeilbiazar designofcurcuminloadedelectrospunpolyhydroxybutyratematasawoundhealingmaterial AT arezoosodagartaleghani designofcurcuminloadedelectrospunpolyhydroxybutyratematasawoundhealingmaterial AT saeedheidarikeshel designofcurcuminloadedelectrospunpolyhydroxybutyratematasawoundhealingmaterial |