Estrogen Receptor Beta Prevents Signet Ring Cell Gastric Carcinoma Progression in Young Patients by Inhibiting Pseudopodia Formation via the mTOR–Arpc1b/EVL Signaling Pathway

Estrogen Receptor Beta Prevents Signet Ring Cell Gastric Carcinoma Progression in Young Patients by Inhibiting Pseudopodia Formation via the mTOR–Arpc1b/EVL Signaling Pathway

Signet ring cell gastric carcinoma (SRCGC) is a poorly differentiated malignancy, and can be highly dangerous in the progression stage. There is a higher male to female ratio among patients with signet ring cell carcinoma as compared to patients with non-SRCGC. ERβ has been found to express in stoma...

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Bibliographic Details
Main Authors: Xingzhou Wang, Xuefeng Xia, En Xu, Zhi Yang, Xiaofei Shen, Shangce Du, Xiaotong Chen, Xiaofeng Lu, Wei Jin, Wenxian Guan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
signet ring cell gastric carcinoma
estrogen receptor beta (ERß)
pseudopodia
clinicopathologic analysis
mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.592919/full

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