Maternal-fetal unit interactions and eutherian neocortical development and evolution
The conserved brain design that primates inherited from early mammals differs from the variable adult brain size and species-specific brain dominances observed across mammals. This variability relies on the emergence of specialized cerebral cortical regions and sub-compartments, triggering an increa...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-07-01
|
| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnana.2013.00022/full |
| _version_ | 1819073569128185856 |
|---|---|
| author | Juan F Montiel Heidy eKaune Heidy eKaune Manuel eMaliqueo |
| author_facet | Juan F Montiel Heidy eKaune Heidy eKaune Manuel eMaliqueo |
| author_sort | Juan F Montiel |
| collection | DOAJ |
| description | The conserved brain design that primates inherited from early mammals differs from the variable adult brain size and species-specific brain dominances observed across mammals. This variability relies on the emergence of specialized cerebral cortical regions and sub-compartments, triggering an increase in brain size, areal interconnectivity and histological complexity that ultimately lies on the activation of developmental programs. Structural placental features are not well correlated with brain enlargement; however, several endocrine pathways could be tuned with the activation of neuronal progenitors in the proliferative neocortical compartments. In this article, we reviewed some mechanisms of eutherians maternal-fetal unit interactions associated with brain development and evolution. We propose a hypothesis of brain evolution where proliferative compartments in primates become activated by 'non-classical' endocrine placental signals participating in different steps of corticogenesis. Changes in the inner placental structure, along with placenta endocrine stimuli over the cortical proliferative activity would allow mammalian brain enlargement with a concomitant shorter gestation span, as an evolutionary strategy to escape from parent-offspring conflict. |
| first_indexed | 2024-12-21T17:55:42Z |
| format | Article |
| id | doaj.art-e6dcda35783c4db2bb44c988623fcd90 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-12-21T17:55:42Z |
| publishDate | 2013-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-e6dcda35783c4db2bb44c988623fcd902022-12-21T18:55:13ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292013-07-01710.3389/fnana.2013.0002252035Maternal-fetal unit interactions and eutherian neocortical development and evolutionJuan F Montiel0Heidy eKaune1Heidy eKaune2Manuel eMaliqueo3Facultad de Medicina, Universidad Diego PortalesFacultad de Medicina, Universidad Diego PortalesUniversity of OxfordFacultad de Medicina, Universidad de ChileThe conserved brain design that primates inherited from early mammals differs from the variable adult brain size and species-specific brain dominances observed across mammals. This variability relies on the emergence of specialized cerebral cortical regions and sub-compartments, triggering an increase in brain size, areal interconnectivity and histological complexity that ultimately lies on the activation of developmental programs. Structural placental features are not well correlated with brain enlargement; however, several endocrine pathways could be tuned with the activation of neuronal progenitors in the proliferative neocortical compartments. In this article, we reviewed some mechanisms of eutherians maternal-fetal unit interactions associated with brain development and evolution. We propose a hypothesis of brain evolution where proliferative compartments in primates become activated by 'non-classical' endocrine placental signals participating in different steps of corticogenesis. Changes in the inner placental structure, along with placenta endocrine stimuli over the cortical proliferative activity would allow mammalian brain enlargement with a concomitant shorter gestation span, as an evolutionary strategy to escape from parent-offspring conflict.http://journal.frontiersin.org/Journal/10.3389/fnana.2013.00022/fullCerebral CortexPlacentaSerotoninTranscriptomeevolutionCerebral cortical development |
| spellingShingle | Juan F Montiel Heidy eKaune Heidy eKaune Manuel eMaliqueo Maternal-fetal unit interactions and eutherian neocortical development and evolution Frontiers in Neuroanatomy Cerebral Cortex Placenta Serotonin Transcriptome evolution Cerebral cortical development |
| title | Maternal-fetal unit interactions and eutherian neocortical development and evolution |
| title_full | Maternal-fetal unit interactions and eutherian neocortical development and evolution |
| title_fullStr | Maternal-fetal unit interactions and eutherian neocortical development and evolution |
| title_full_unstemmed | Maternal-fetal unit interactions and eutherian neocortical development and evolution |
| title_short | Maternal-fetal unit interactions and eutherian neocortical development and evolution |
| title_sort | maternal fetal unit interactions and eutherian neocortical development and evolution |
| topic | Cerebral Cortex Placenta Serotonin Transcriptome evolution Cerebral cortical development |
| url | http://journal.frontiersin.org/Journal/10.3389/fnana.2013.00022/full |
| work_keys_str_mv | AT juanfmontiel maternalfetalunitinteractionsandeutherianneocorticaldevelopmentandevolution AT heidyekaune maternalfetalunitinteractionsandeutherianneocorticaldevelopmentandevolution AT heidyekaune maternalfetalunitinteractionsandeutherianneocorticaldevelopmentandevolution AT manuelemaliqueo maternalfetalunitinteractionsandeutherianneocorticaldevelopmentandevolution |