Fasting enhances the response of glioma to chemo- and radiotherapy.
Glioma, including anaplastic astrocytoma and glioblastoma multiforme (GBM) are among the most commonly diagnosed malignant adult brain tumors. GBM is a highly invasive and angiogenic tumor, resulting in a 12 to 15 months median survival. The treatment of GBM is multimodal and includes surgical resec...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3439413?pdf=render |
| _version_ | 1818694809475350528 |
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| author | Fernando Safdie Sebastian Brandhorst Min Wei Weijun Wang Changhan Lee Saewon Hwang Peter S Conti Thomas C Chen Valter D Longo |
| author_facet | Fernando Safdie Sebastian Brandhorst Min Wei Weijun Wang Changhan Lee Saewon Hwang Peter S Conti Thomas C Chen Valter D Longo |
| author_sort | Fernando Safdie |
| collection | DOAJ |
| description | Glioma, including anaplastic astrocytoma and glioblastoma multiforme (GBM) are among the most commonly diagnosed malignant adult brain tumors. GBM is a highly invasive and angiogenic tumor, resulting in a 12 to 15 months median survival. The treatment of GBM is multimodal and includes surgical resection, followed by adjuvant radio-and chemotherapy. We have previously reported that short-term starvation (STS) enhances the therapeutic index of chemo-treatments by differentially protecting normal cells against and/or sensitizing tumor cells to chemotoxicity.To test the effect of starvation on glioma cells in vitro, we treated primary mouse glia, murine GL26, rat C6 and human U251, LN229 and A172 glioma cells with Temozolomide in ad lib and STS mimicking conditions. In vivo, mice with subcutaneous or intracranial models of GL26 glioma were starved for 48 hours prior to radio- or chemotherapy and the effects on tumor progression and survival were measured. Starvation-mimicking conditions sensitized murine, rat and human glioma cells, but not primary mixed glia, to chemotherapy. In vivo, starvation for 48 hours, which causes a significant reduction in blood glucose and circulating insulin-like growth factor 1 (IGF-1) levels, sensitized both subcutaneous and intracranial glioma models to radio-and chemotherapy.Starvation-induced cancer sensitization to radio- or chemotherapy leads to extended survival in the in vivo glioma models tested. These results indicate that fasting and fasting-mimicking interventions could enhance the efficacy of existing cancer treatments against aggressive glioma in patients. |
| first_indexed | 2024-12-17T13:35:29Z |
| format | Article |
| id | doaj.art-e6dded7d98694302bf4c556151f599c7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T13:35:29Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e6dded7d98694302bf4c556151f599c72022-12-21T21:46:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0179e4460310.1371/journal.pone.0044603Fasting enhances the response of glioma to chemo- and radiotherapy.Fernando SafdieSebastian BrandhorstMin WeiWeijun WangChanghan LeeSaewon HwangPeter S ContiThomas C ChenValter D LongoGlioma, including anaplastic astrocytoma and glioblastoma multiforme (GBM) are among the most commonly diagnosed malignant adult brain tumors. GBM is a highly invasive and angiogenic tumor, resulting in a 12 to 15 months median survival. The treatment of GBM is multimodal and includes surgical resection, followed by adjuvant radio-and chemotherapy. We have previously reported that short-term starvation (STS) enhances the therapeutic index of chemo-treatments by differentially protecting normal cells against and/or sensitizing tumor cells to chemotoxicity.To test the effect of starvation on glioma cells in vitro, we treated primary mouse glia, murine GL26, rat C6 and human U251, LN229 and A172 glioma cells with Temozolomide in ad lib and STS mimicking conditions. In vivo, mice with subcutaneous or intracranial models of GL26 glioma were starved for 48 hours prior to radio- or chemotherapy and the effects on tumor progression and survival were measured. Starvation-mimicking conditions sensitized murine, rat and human glioma cells, but not primary mixed glia, to chemotherapy. In vivo, starvation for 48 hours, which causes a significant reduction in blood glucose and circulating insulin-like growth factor 1 (IGF-1) levels, sensitized both subcutaneous and intracranial glioma models to radio-and chemotherapy.Starvation-induced cancer sensitization to radio- or chemotherapy leads to extended survival in the in vivo glioma models tested. These results indicate that fasting and fasting-mimicking interventions could enhance the efficacy of existing cancer treatments against aggressive glioma in patients.http://europepmc.org/articles/PMC3439413?pdf=render |
| spellingShingle | Fernando Safdie Sebastian Brandhorst Min Wei Weijun Wang Changhan Lee Saewon Hwang Peter S Conti Thomas C Chen Valter D Longo Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS ONE |
| title | Fasting enhances the response of glioma to chemo- and radiotherapy. |
| title_full | Fasting enhances the response of glioma to chemo- and radiotherapy. |
| title_fullStr | Fasting enhances the response of glioma to chemo- and radiotherapy. |
| title_full_unstemmed | Fasting enhances the response of glioma to chemo- and radiotherapy. |
| title_short | Fasting enhances the response of glioma to chemo- and radiotherapy. |
| title_sort | fasting enhances the response of glioma to chemo and radiotherapy |
| url | http://europepmc.org/articles/PMC3439413?pdf=render |
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