The Relationship of Statins Usage and Bone Mineral Density in Postmenopausal Women
Background: Osteoporosis is a common disease that is most prevalent in postmenopausal women. Statins are lipid lowering agents and their role in increasing bone mineral density has been reported in many studies. We conducted this study to evaluate the relationship of statin consumption and bone dens...
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| Формат: | Статья |
| Язык: | fas |
| Опубликовано: |
Isfahan University of Medical Sciences
2014-06-01
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| Серии: | مجله دانشکده پزشکی اصفهان |
| Предметы: | |
| Online-ссылка: | http://jims.mui.ac.ir/index.php/jims/article/view/3428 |
| _version_ | 1827881764593336320 |
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| author | Gholamreza Dashti Mohammadreza Salamat Abbas Shobeiri Amirhossein Salamat |
| author_facet | Gholamreza Dashti Mohammadreza Salamat Abbas Shobeiri Amirhossein Salamat |
| author_sort | Gholamreza Dashti |
| collection | DOAJ |
| description | Background: Osteoporosis is a common disease that is most prevalent in postmenopausal women. Statins are lipid lowering agents and their role in increasing bone mineral density has been reported in many studies. We conducted this study to evaluate the relationship of statin consumption and bone density in postmenopausal women.
Methods: 350 patients with a mean age of 62.03 ± 6.12 years (range: 43-82 years) were enrolled in this study. Patients underwent dual-energy x-ray absorptiometry (DXA) measurements at hip, lumbar spines (L2, L3, and L4), greater trochanter and femur neck. Statin usage by patients was recorded. Results [showed as T-score and bone mineral density (BMD) in g/cm2] were compared between the patients who were or were not taking statins. The patients were divided in three groups according to T-score (normal, osteopenic and osteoporotic). Then, the data were analyzed using chi-square (for qualitative variables), t (for quantitative variables) and the Mann-Whitney tests via SPSS18 software.
Findings: Significant differences were found between the two groups in mean BMD of lumbar spines (L2, L3, and L4), greater trochanter and femur neck. Statin users had higher BMD. No significant difference in BMD of hip was observed. Frequency distribution of patients with osteoporosis, osteopenia, and normal density of lumbar spines (L2, L3, and L4) and femur neck in two groups was found to be significantly different.
Conclusion: Statins showed to have positive impact on bone density in lumbar spines (L2, L3, and L4), greater trochanter and femur neck, but in BMD of hip no significant difference was observed. According to the results of this study, statins can have an important role in prevention of osteoporosis. |
| first_indexed | 2024-03-12T18:45:12Z |
| format | Article |
| id | doaj.art-e6ddee733ebb47c29f10f138c28a5e2c |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T18:45:12Z |
| publishDate | 2014-06-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-e6ddee733ebb47c29f10f138c28a5e2c2023-08-02T07:44:21ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2014-06-01322814935021580The Relationship of Statins Usage and Bone Mineral Density in Postmenopausal WomenGholamreza Dashti0Mohammadreza Salamat1Abbas Shobeiri2Amirhossein Salamat3Associate Professor, Department of Anatomical Sciences and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, School of Medicine AND Student Research committee, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Biomedical Engineering, University of Birmingham, United KingdomBackground: Osteoporosis is a common disease that is most prevalent in postmenopausal women. Statins are lipid lowering agents and their role in increasing bone mineral density has been reported in many studies. We conducted this study to evaluate the relationship of statin consumption and bone density in postmenopausal women. Methods: 350 patients with a mean age of 62.03 ± 6.12 years (range: 43-82 years) were enrolled in this study. Patients underwent dual-energy x-ray absorptiometry (DXA) measurements at hip, lumbar spines (L2, L3, and L4), greater trochanter and femur neck. Statin usage by patients was recorded. Results [showed as T-score and bone mineral density (BMD) in g/cm2] were compared between the patients who were or were not taking statins. The patients were divided in three groups according to T-score (normal, osteopenic and osteoporotic). Then, the data were analyzed using chi-square (for qualitative variables), t (for quantitative variables) and the Mann-Whitney tests via SPSS18 software. Findings: Significant differences were found between the two groups in mean BMD of lumbar spines (L2, L3, and L4), greater trochanter and femur neck. Statin users had higher BMD. No significant difference in BMD of hip was observed. Frequency distribution of patients with osteoporosis, osteopenia, and normal density of lumbar spines (L2, L3, and L4) and femur neck in two groups was found to be significantly different. Conclusion: Statins showed to have positive impact on bone density in lumbar spines (L2, L3, and L4), greater trochanter and femur neck, but in BMD of hip no significant difference was observed. According to the results of this study, statins can have an important role in prevention of osteoporosis.http://jims.mui.ac.ir/index.php/jims/article/view/3428Bone mineral densityOsteoporosisStatinsPostmenopausal women |
| spellingShingle | Gholamreza Dashti Mohammadreza Salamat Abbas Shobeiri Amirhossein Salamat The Relationship of Statins Usage and Bone Mineral Density in Postmenopausal Women مجله دانشکده پزشکی اصفهان Bone mineral density Osteoporosis Statins Postmenopausal women |
| title | The Relationship of Statins Usage and Bone Mineral Density in Postmenopausal Women |
| title_full | The Relationship of Statins Usage and Bone Mineral Density in Postmenopausal Women |
| title_fullStr | The Relationship of Statins Usage and Bone Mineral Density in Postmenopausal Women |
| title_full_unstemmed | The Relationship of Statins Usage and Bone Mineral Density in Postmenopausal Women |
| title_short | The Relationship of Statins Usage and Bone Mineral Density in Postmenopausal Women |
| title_sort | relationship of statins usage and bone mineral density in postmenopausal women |
| topic | Bone mineral density Osteoporosis Statins Postmenopausal women |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/3428 |
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