Oral health and plaque microbial profile in juvenile idiopathic arthritis
Abstract Background The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juvenile idiopathic arthritis (JIA). Methods A cross-sectional exploratory...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Pediatric Rheumatology Online Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12969-019-0387-5 |
| _version_ | 1819295766208839680 |
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| author | Sriharsha Grevich Peggy Lee Brian Leroux Sarah Ringold Richard Darveau Gretchen Henstorf Joel Berg Amy Kim Elizabeth Velan Joseph Kelly Camille Baltuck Anne Reeves Hannah Leahey Kyle Hager Mitchell Brittnacher Hillary Hayden Samuel Miller Jeffrey McLean Anne Stevens |
| author_facet | Sriharsha Grevich Peggy Lee Brian Leroux Sarah Ringold Richard Darveau Gretchen Henstorf Joel Berg Amy Kim Elizabeth Velan Joseph Kelly Camille Baltuck Anne Reeves Hannah Leahey Kyle Hager Mitchell Brittnacher Hillary Hayden Samuel Miller Jeffrey McLean Anne Stevens |
| author_sort | Sriharsha Grevich |
| collection | DOAJ |
| description | Abstract Background The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juvenile idiopathic arthritis (JIA). Methods A cross-sectional exploratory study of subjects aged 10–18 years with oligoarticular, extended oligoarticular and polyarticular JIA was conducted. Control groups included pediatric dental clinic patients and healthy volunteers. The primary aim was to test for an association between dental health indices and JIA; the secondary aim was to characterize the microbial profile of supragingival plaque using 16S rRNA gene sequencing. Results The study included 85 patients with JIA, 62 dental patients and 11 healthy child controls. JIA patients overall had significantly more gingival inflammation compared to dental patients, as evidenced by bleeding on probing of the gingiva, the most specific sign of active inflammation (p = 0.02). Overall, however, there was a trend towards better dental hygiene in the JIA patients compared to dental patients, based on indices for plaque, decay, and periodontitis. In the JIA patients, plaque microbiota analysis revealed bacteria belonging to genera Haemophilus or Kingella elevated, and Corynebacterium underrepresented. In poly JIA, bacteria belonging to the genus Porphyromonas was overrepresented and Prevotella was underrepresented. Conclusion Increased gingival inflammation in JIA was independent of general oral health, and thus cannot be attributed to poor dental hygiene secondary to disability. The variation of microbial profile in JIA patients could indicate a possible link between gingivitis and synovial inflammation. |
| first_indexed | 2024-12-24T04:47:26Z |
| format | Article |
| id | doaj.art-e6df6fae752e4935baa65b81513e1b40 |
| institution | Directory Open Access Journal |
| issn | 1546-0096 |
| language | English |
| last_indexed | 2024-12-24T04:47:26Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Pediatric Rheumatology Online Journal |
| spelling | doaj.art-e6df6fae752e4935baa65b81513e1b402022-12-21T17:14:39ZengBMCPediatric Rheumatology Online Journal1546-00962019-12-011711910.1186/s12969-019-0387-5Oral health and plaque microbial profile in juvenile idiopathic arthritisSriharsha Grevich0Peggy Lee1Brian Leroux2Sarah Ringold3Richard Darveau4Gretchen Henstorf5Joel Berg6Amy Kim7Elizabeth Velan8Joseph Kelly9Camille Baltuck10Anne Reeves11Hannah Leahey12Kyle Hager13Mitchell Brittnacher14Hillary Hayden15Samuel Miller16Jeffrey McLean17Anne Stevens18Seattle Children’s HospitalDepartment of Periodontics, School of Dentistry, University of WashingtonDepartment of Periodontics, School of Dentistry, University of WashingtonSeattle Children’s HospitalDepartment of Periodontics, School of Dentistry, University of WashingtonCenter for Immunity and Immunotherapies, Seattle Children’s Research InstituteDepartment of Periodontics, School of Dentistry, University of WashingtonDepartment of Periodontics, School of Dentistry, University of WashingtonDepartment of Periodontics, School of Dentistry, University of WashingtonDepartment of Periodontics, School of Dentistry, University of WashingtonDepartment of Periodontics, School of Dentistry, University of WashingtonDepartment of Periodontics, School of Dentistry, University of WashingtonCenter for Immunity and Immunotherapies, Seattle Children’s Research InstituteDepartment of Microbiology, University of WashingtonDepartment of Microbiology, University of WashingtonDepartment of Microbiology, University of WashingtonDepartment of Microbiology, University of WashingtonDepartment of Periodontics, School of Dentistry, University of WashingtonSeattle Children’s HospitalAbstract Background The oral microbiota has been implicated in the pathogenesis of rheumatoid arthritis through activation of mucosal immunity. This study tested for associations between oral health, microbial communities and juvenile idiopathic arthritis (JIA). Methods A cross-sectional exploratory study of subjects aged 10–18 years with oligoarticular, extended oligoarticular and polyarticular JIA was conducted. Control groups included pediatric dental clinic patients and healthy volunteers. The primary aim was to test for an association between dental health indices and JIA; the secondary aim was to characterize the microbial profile of supragingival plaque using 16S rRNA gene sequencing. Results The study included 85 patients with JIA, 62 dental patients and 11 healthy child controls. JIA patients overall had significantly more gingival inflammation compared to dental patients, as evidenced by bleeding on probing of the gingiva, the most specific sign of active inflammation (p = 0.02). Overall, however, there was a trend towards better dental hygiene in the JIA patients compared to dental patients, based on indices for plaque, decay, and periodontitis. In the JIA patients, plaque microbiota analysis revealed bacteria belonging to genera Haemophilus or Kingella elevated, and Corynebacterium underrepresented. In poly JIA, bacteria belonging to the genus Porphyromonas was overrepresented and Prevotella was underrepresented. Conclusion Increased gingival inflammation in JIA was independent of general oral health, and thus cannot be attributed to poor dental hygiene secondary to disability. The variation of microbial profile in JIA patients could indicate a possible link between gingivitis and synovial inflammation.https://doi.org/10.1186/s12969-019-0387-5Juvenile idiopathic arthritisOral healthGingivitisMicrobiota |
| spellingShingle | Sriharsha Grevich Peggy Lee Brian Leroux Sarah Ringold Richard Darveau Gretchen Henstorf Joel Berg Amy Kim Elizabeth Velan Joseph Kelly Camille Baltuck Anne Reeves Hannah Leahey Kyle Hager Mitchell Brittnacher Hillary Hayden Samuel Miller Jeffrey McLean Anne Stevens Oral health and plaque microbial profile in juvenile idiopathic arthritis Pediatric Rheumatology Online Journal Juvenile idiopathic arthritis Oral health Gingivitis Microbiota |
| title | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
| title_full | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
| title_fullStr | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
| title_full_unstemmed | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
| title_short | Oral health and plaque microbial profile in juvenile idiopathic arthritis |
| title_sort | oral health and plaque microbial profile in juvenile idiopathic arthritis |
| topic | Juvenile idiopathic arthritis Oral health Gingivitis Microbiota |
| url | https://doi.org/10.1186/s12969-019-0387-5 |
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