Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier
Abstract This work mainly focuses on the graphene oxide (GO)‐assisted sustainable drug delivery of famotidine (FMT) drug. Famotidine is loaded onto GO and encapsulated by chitosan (CH). UV‐visible spectroscopy, field emission scan electron microscopy, and atomic force microscopy confirm the loading...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-10-01
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| Series: | Global Challenges |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/gch2.201900002 |
| _version_ | 1818562970000556032 |
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| author | Chetan Ramesh Mahajan Lalit B. Joshi Umakant Varma Jitendra B. Naik Vijay Raman Chaudhari Satyendra Mishra |
| author_facet | Chetan Ramesh Mahajan Lalit B. Joshi Umakant Varma Jitendra B. Naik Vijay Raman Chaudhari Satyendra Mishra |
| author_sort | Chetan Ramesh Mahajan |
| collection | DOAJ |
| description | Abstract This work mainly focuses on the graphene oxide (GO)‐assisted sustainable drug delivery of famotidine (FMT) drug. Famotidine is loaded onto GO and encapsulated by chitosan (CH). UV‐visible spectroscopy, field emission scan electron microscopy, and atomic force microscopy confirm the loading of FMT on GO. An interaction of FMT with GO and CH through amine functionalities is confirmed by Fourier‐transform infrared spectroscopy. Differential scanning calorimetric and cyclic voltammetric investigations confirm the compatibility of FMT and its retaining activity within chitosan‐functionalized graphene oxide (CHGO) composite. Encapsulation efficiency of FMT is determined for various CHGO‐FMT combinations and found to be higher at 1:9 ratio. The in vitro drug release profile is studied using a dissolution test apparatus in 0.1 m phosphate buffer medium (pH = 4.5), which shows sustainable drug release up to 12 h, which is greater than the market product (Complete release within 2 h). Comparative study of drug encapsulated with CH and without GO elucidates that GO is responsible for the sustainable release. The “n” value obtained from slope using Korsmeyer–Peppas model suggests the super case‐II transport mechanism. |
| first_indexed | 2024-12-14T01:10:43Z |
| format | Article |
| id | doaj.art-e6e077adee0747afa0bdb027700c4680 |
| institution | Directory Open Access Journal |
| issn | 2056-6646 |
| language | English |
| last_indexed | 2024-12-14T01:10:43Z |
| publishDate | 2019-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Global Challenges |
| spelling | doaj.art-e6e077adee0747afa0bdb027700c46802022-12-21T23:22:45ZengWileyGlobal Challenges2056-66462019-10-01310n/an/a10.1002/gch2.201900002Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as NanocarrierChetan Ramesh Mahajan0Lalit B. Joshi1Umakant Varma2Jitendra B. Naik3Vijay Raman Chaudhari4Satyendra Mishra5University Institute of Chemical Technology North Maharashtra University Jalgaon 425001 Maharashtra IndiaUniversity Institute of Chemical Technology North Maharashtra University Jalgaon 425001 Maharashtra IndiaUniversity Institute of Chemical Technology North Maharashtra University Jalgaon 425001 Maharashtra IndiaUniversity Institute of Chemical Technology North Maharashtra University Jalgaon 425001 Maharashtra IndiaUniversity Institute of Chemical Technology North Maharashtra University Jalgaon 425001 Maharashtra IndiaUniversity Institute of Chemical Technology North Maharashtra University Jalgaon 425001 Maharashtra IndiaAbstract This work mainly focuses on the graphene oxide (GO)‐assisted sustainable drug delivery of famotidine (FMT) drug. Famotidine is loaded onto GO and encapsulated by chitosan (CH). UV‐visible spectroscopy, field emission scan electron microscopy, and atomic force microscopy confirm the loading of FMT on GO. An interaction of FMT with GO and CH through amine functionalities is confirmed by Fourier‐transform infrared spectroscopy. Differential scanning calorimetric and cyclic voltammetric investigations confirm the compatibility of FMT and its retaining activity within chitosan‐functionalized graphene oxide (CHGO) composite. Encapsulation efficiency of FMT is determined for various CHGO‐FMT combinations and found to be higher at 1:9 ratio. The in vitro drug release profile is studied using a dissolution test apparatus in 0.1 m phosphate buffer medium (pH = 4.5), which shows sustainable drug release up to 12 h, which is greater than the market product (Complete release within 2 h). Comparative study of drug encapsulated with CH and without GO elucidates that GO is responsible for the sustainable release. The “n” value obtained from slope using Korsmeyer–Peppas model suggests the super case‐II transport mechanism.https://doi.org/10.1002/gch2.201900002chitosanfamotidinegraphene oxidein vitro drug releasesustainable drug delivery |
| spellingShingle | Chetan Ramesh Mahajan Lalit B. Joshi Umakant Varma Jitendra B. Naik Vijay Raman Chaudhari Satyendra Mishra Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier Global Challenges chitosan famotidine graphene oxide in vitro drug release sustainable drug delivery |
| title | Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier |
| title_full | Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier |
| title_fullStr | Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier |
| title_full_unstemmed | Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier |
| title_short | Sustainable Drug Delivery of Famotidine Using Chitosan‐Functionalized Graphene Oxide as Nanocarrier |
| title_sort | sustainable drug delivery of famotidine using chitosan functionalized graphene oxide as nanocarrier |
| topic | chitosan famotidine graphene oxide in vitro drug release sustainable drug delivery |
| url | https://doi.org/10.1002/gch2.201900002 |
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