Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center Study
Background Thrombotic antiphospholipid syndrome (APS) is a systemic autoimmune disease; its diagnosis requires meeting both clinical and laboratory criteria. Prevalence rates of immunoglobulin (Ig) A anticardiolipin antibodies (aCL) and IgA anti-β 2 glycoprotein I antibodies (aβ 2 GPI) remain unknow...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-04-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296221081129 |
| _version_ | 1811297652562722816 |
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| author | Zhenzhen Su MM Zhuochun Huang MD Jiuliang Zhao MD Mengtao Li MD Jing Hu BS Xiaofeng Zeng MD Chaojun Hu PhD Bin Yang PhD |
| author_facet | Zhenzhen Su MM Zhuochun Huang MD Jiuliang Zhao MD Mengtao Li MD Jing Hu BS Xiaofeng Zeng MD Chaojun Hu PhD Bin Yang PhD |
| author_sort | Zhenzhen Su MM |
| collection | DOAJ |
| description | Background Thrombotic antiphospholipid syndrome (APS) is a systemic autoimmune disease; its diagnosis requires meeting both clinical and laboratory criteria. Prevalence rates of immunoglobulin (Ig) A anticardiolipin antibodies (aCL) and IgA anti-β 2 glycoprotein I antibodies (aβ 2 GPI) remain unknown, and the clinical value of these antibodies to APS classification remains controversial. Therefore, we aimed to examine both items in the Chinese population. Methods Using chemiluminescence immunoassay, antiphospholipid antibodies (aPL) were quantified in 12,582 hospital-based general population, 278 thrombotic APS patients, and 233 healthy controls. Results In the general population, the positive rates of IgA aCL and IgA aβ 2 GPI antibodies were 2.87% and 1.99%, respectively. Furthermore, isolated IgA aPL-positivity rate was 0.72% in patients with APS, which was comparable to those in the general population (0.68%, p = 1) and in healthy controls (0.43%, p = 1). Among the IgA aPL-positive individuals in the general population, isolated IgA-positive individuals had lower serum levels of IgA antibodies ( p = 0.007 for IgA aCL and p = 0.059 for IgA aβ 2 GPI). Regarding to APS classification, adding IgA aPL into conventional aPL assays may not improve and may even deteriorate the net reclassification index for APS; besides, no association between thrombosis and IgA aPL was observed. Conclusions this study assessed the prevalence of various aPL in Chinese population. IgA aPL may not enhance the classification ability of established laboratory criteria for thrombotic APS. Our data do not support the addition of IgA aPL to conventional aPL assays. |
| first_indexed | 2024-04-13T06:08:21Z |
| format | Article |
| id | doaj.art-e6e08345657643b4b9eee12f44193c2a |
| institution | Directory Open Access Journal |
| issn | 1938-2723 |
| language | English |
| last_indexed | 2024-04-13T06:08:21Z |
| publishDate | 2022-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj.art-e6e08345657643b4b9eee12f44193c2a2022-12-22T02:59:11ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232022-04-012810.1177/10760296221081129Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center StudyZhenzhen Su MM0Zhuochun Huang MD1Jiuliang Zhao MD2Mengtao Li MD3Jing Hu BS4Xiaofeng Zeng MD5 Chaojun Hu PhD6Bin Yang PhD7 , Chengdu, China , Chengdu, China National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China , Chengdu, China National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China , Chengdu, ChinaBackground Thrombotic antiphospholipid syndrome (APS) is a systemic autoimmune disease; its diagnosis requires meeting both clinical and laboratory criteria. Prevalence rates of immunoglobulin (Ig) A anticardiolipin antibodies (aCL) and IgA anti-β 2 glycoprotein I antibodies (aβ 2 GPI) remain unknown, and the clinical value of these antibodies to APS classification remains controversial. Therefore, we aimed to examine both items in the Chinese population. Methods Using chemiluminescence immunoassay, antiphospholipid antibodies (aPL) were quantified in 12,582 hospital-based general population, 278 thrombotic APS patients, and 233 healthy controls. Results In the general population, the positive rates of IgA aCL and IgA aβ 2 GPI antibodies were 2.87% and 1.99%, respectively. Furthermore, isolated IgA aPL-positivity rate was 0.72% in patients with APS, which was comparable to those in the general population (0.68%, p = 1) and in healthy controls (0.43%, p = 1). Among the IgA aPL-positive individuals in the general population, isolated IgA-positive individuals had lower serum levels of IgA antibodies ( p = 0.007 for IgA aCL and p = 0.059 for IgA aβ 2 GPI). Regarding to APS classification, adding IgA aPL into conventional aPL assays may not improve and may even deteriorate the net reclassification index for APS; besides, no association between thrombosis and IgA aPL was observed. Conclusions this study assessed the prevalence of various aPL in Chinese population. IgA aPL may not enhance the classification ability of established laboratory criteria for thrombotic APS. Our data do not support the addition of IgA aPL to conventional aPL assays.https://doi.org/10.1177/10760296221081129 |
| spellingShingle | Zhenzhen Su MM Zhuochun Huang MD Jiuliang Zhao MD Mengtao Li MD Jing Hu BS Xiaofeng Zeng MD Chaojun Hu PhD Bin Yang PhD Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center Study Clinical and Applied Thrombosis/Hemostasis |
| title | Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center Study |
| title_full | Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center Study |
| title_fullStr | Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center Study |
| title_full_unstemmed | Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center Study |
| title_short | Detection of IgA Antiphospholipid Antibodies Does not Improve Thrombotic Antiphospholipid Syndrome Classification: A two-Center Study |
| title_sort | detection of iga antiphospholipid antibodies does not improve thrombotic antiphospholipid syndrome classification a two center study |
| url | https://doi.org/10.1177/10760296221081129 |
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