Coarse-Grained Models for Protein-Cell Membrane Interactions
The physiological properties of biological soft matter are the product of collective interactions, which span many time and length scales. Recent computational modeling efforts have helped illuminate experiments that characterize the ways in which proteins modulate membrane physics. Linking these mo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-07-01
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| Series: | Polymers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4360/5/3/890 |
| _version_ | 1811207951235416064 |
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| author | Ryan Bradley Ravi Radhakrishnan |
| author_facet | Ryan Bradley Ravi Radhakrishnan |
| author_sort | Ryan Bradley |
| collection | DOAJ |
| description | The physiological properties of biological soft matter are the product of collective interactions, which span many time and length scales. Recent computational modeling efforts have helped illuminate experiments that characterize the ways in which proteins modulate membrane physics. Linking these models across time and length scales in a multiscale model explains how atomistic information propagates to larger scales. This paper reviews continuum modeling and coarse-grained molecular dynamics methods, which connect atomistic simulations and single-molecule experiments with the observed microscopic or mesoscale properties of soft-matter systems essential to our understanding of cells, particularly those involved in sculpting and remodeling cell membranes. |
| first_indexed | 2024-04-12T04:12:37Z |
| format | Article |
| id | doaj.art-e6e15866ad6b431ab1ef6537c97609d0 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-04-12T04:12:37Z |
| publishDate | 2013-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-e6e15866ad6b431ab1ef6537c97609d02022-12-22T03:48:28ZengMDPI AGPolymers2073-43602013-07-015389093610.3390/polym5030890Coarse-Grained Models for Protein-Cell Membrane InteractionsRyan BradleyRavi RadhakrishnanThe physiological properties of biological soft matter are the product of collective interactions, which span many time and length scales. Recent computational modeling efforts have helped illuminate experiments that characterize the ways in which proteins modulate membrane physics. Linking these models across time and length scales in a multiscale model explains how atomistic information propagates to larger scales. This paper reviews continuum modeling and coarse-grained molecular dynamics methods, which connect atomistic simulations and single-molecule experiments with the observed microscopic or mesoscale properties of soft-matter systems essential to our understanding of cells, particularly those involved in sculpting and remodeling cell membranes.http://www.mdpi.com/2073-4360/5/3/890molecular dynamicscoarse-grained modelmembrane proteins |
| spellingShingle | Ryan Bradley Ravi Radhakrishnan Coarse-Grained Models for Protein-Cell Membrane Interactions Polymers molecular dynamics coarse-grained model membrane proteins |
| title | Coarse-Grained Models for Protein-Cell Membrane Interactions |
| title_full | Coarse-Grained Models for Protein-Cell Membrane Interactions |
| title_fullStr | Coarse-Grained Models for Protein-Cell Membrane Interactions |
| title_full_unstemmed | Coarse-Grained Models for Protein-Cell Membrane Interactions |
| title_short | Coarse-Grained Models for Protein-Cell Membrane Interactions |
| title_sort | coarse grained models for protein cell membrane interactions |
| topic | molecular dynamics coarse-grained model membrane proteins |
| url | http://www.mdpi.com/2073-4360/5/3/890 |
| work_keys_str_mv | AT ryanbradley coarsegrainedmodelsforproteincellmembraneinteractions AT raviradhakrishnan coarsegrainedmodelsforproteincellmembraneinteractions |