Comparing the Daily Versus the Intermittent Regimens of the Anti-Tubercular Chemotherapy in the Initial Intensive Phase in Non-HIV, Sputum Positive, Pulmonary Tuberculosis Patients
ABSTRACT Background: Tuberculosis (TB) is a major health problem in the universe and India is no longer exempted from this crisis. The emergence of HIV and MDRTB (Multi Drug Resistant Tuberculosis) have further made the situation critical. Aims: Our aim was to compare the efficacy of the daily a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/2750/25-%205122_E(C)_PF1(M)_F(P)_PF1(P)_PFA(N)_OLF_u_(P).pdf |
| Summary: | ABSTRACT
Background: Tuberculosis (TB) is a major health problem in the
universe and India is no longer exempted from this crisis. The
emergence of HIV and MDRTB (Multi Drug Resistant Tuberculosis) have further made the situation critical.
Aims: Our aim was to compare the efficacy of the daily and the
intermittent doses of the Anti Tubercular Drug (ATD) therapy
which is under the Revised National Tuberculosis Control Programme, amongst the sputum positive pulmonary tuberculosis
in terms of the sputum conversion rate at the end of the initial
phase , the default rate and the adverse drug reactions.
Methods: This was an observational prospective study.
Material: Eighty three patients were selected from the out patient and the inpatient departments of a tertiary medical centre
in India.
Results: Forty three cases received an intermittent regimen,
where the major age group belonged to the under 40 years age
group, the default rate to the therapy was 9.3%, the sputum
conversion rate was 94.87% and adverse drug reactions were
found in 25.58% of the patients. In the daily regimen, there was
an equal proportion of the age group of the patients, both above
and below 40 yrs, the sputum conversion rate was 94.74%, a
default rate was found in 5% cases and adverse reactions were
found in 35% of the cases.
Conclusion: Both the intermittent and the daily regimens
showed equal sputum conversion rates and the drug default
cases were found more in the intermittent group. However,
the adverse reactions were found more in the daily regimen
category. |
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| ISSN: | 2249-782X 0973-709X |