Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development
The most common form of hypertension in young adults is isolated diastolic hypertension. Diastolic arterial pressure is determined by the total peripheral resistance and depends on both vascular hindrance and blood viscosity. The aim of our work was to study the efficiency of pentoxifylline (PTX) in...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-08-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | http://dx.doi.org/10.1080/10641963.2017.1291662 |
| _version_ | 1797681551780085760 |
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| author | Mark B. Plotnikov Oleg I. Aliev Alexander Y. Shamanaev Anastasia V. Sidekhmenova Yana Anfinogenova Anna M. Anishchenko Tatiana I. Fomina Alexander M. Arkhipov |
| author_facet | Mark B. Plotnikov Oleg I. Aliev Alexander Y. Shamanaev Anastasia V. Sidekhmenova Yana Anfinogenova Anna M. Anishchenko Tatiana I. Fomina Alexander M. Arkhipov |
| author_sort | Mark B. Plotnikov |
| collection | DOAJ |
| description | The most common form of hypertension in young adults is isolated diastolic hypertension. Diastolic arterial pressure is determined by the total peripheral resistance and depends on both vascular hindrance and blood viscosity. The aim of our work was to study the efficiency of pentoxifylline (PTX) in young spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. The effects of a treatment course with PTX (100 mg/kg/day p.o. for 6 weeks, from 5 to 11 weeks old) on the mean, systolic, and diastolic blood pressure (BP); stroke volume; cardiac output; total peripheral resistance (TPR); whole blood viscosity (BV); plasma viscosity; hematocrit; RBC aggregation and deformability; local cerebral blood flow (lCBF); and microvascularization of the visual cortex were studied in SHRs in comparison with control SHRs and Wistar Kyoto rats. PTX-treated SHRs had significantly lower systolic, diastolic, and mean BP (by 24%, 26%, and 15%, respectively) and BV (by 5–9%) and a higher erythrocyte deformability index (by 1.5–2%), lCBF (by 42%), average diameter of capillaries (by 11%), density of the capillary network (by 23%), and percentage of capillaries with a diameter of 3–7 µm in comparison with control SHRs. In conclusion, PTX exerted positive effects on the hemodynamic, hemorheological, and microcirculatory parameters in SHRs during the development of arterial hypertension. |
| first_indexed | 2024-03-11T23:46:30Z |
| format | Article |
| id | doaj.art-e6e218655e0e43c8b9cea43059ad86a8 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:46:30Z |
| publishDate | 2017-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-e6e218655e0e43c8b9cea43059ad86a82023-09-19T09:24:45ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062017-08-0139657057810.1080/10641963.2017.12916621291662Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension developmentMark B. Plotnikov0Oleg I. Aliev1Alexander Y. Shamanaev2Anastasia V. Sidekhmenova3Yana Anfinogenova4Anna M. Anishchenko5Tatiana I. Fomina6Alexander M. Arkhipov7Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of SciencesGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of SciencesGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of SciencesGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of SciencesGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of SciencesGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of SciencesThe most common form of hypertension in young adults is isolated diastolic hypertension. Diastolic arterial pressure is determined by the total peripheral resistance and depends on both vascular hindrance and blood viscosity. The aim of our work was to study the efficiency of pentoxifylline (PTX) in young spontaneously hypertensive rats (SHRs) during the development of arterial hypertension. The effects of a treatment course with PTX (100 mg/kg/day p.o. for 6 weeks, from 5 to 11 weeks old) on the mean, systolic, and diastolic blood pressure (BP); stroke volume; cardiac output; total peripheral resistance (TPR); whole blood viscosity (BV); plasma viscosity; hematocrit; RBC aggregation and deformability; local cerebral blood flow (lCBF); and microvascularization of the visual cortex were studied in SHRs in comparison with control SHRs and Wistar Kyoto rats. PTX-treated SHRs had significantly lower systolic, diastolic, and mean BP (by 24%, 26%, and 15%, respectively) and BV (by 5–9%) and a higher erythrocyte deformability index (by 1.5–2%), lCBF (by 42%), average diameter of capillaries (by 11%), density of the capillary network (by 23%), and percentage of capillaries with a diameter of 3–7 µm in comparison with control SHRs. In conclusion, PTX exerted positive effects on the hemodynamic, hemorheological, and microcirculatory parameters in SHRs during the development of arterial hypertension.http://dx.doi.org/10.1080/10641963.2017.1291662arterial blood pressureblood viscositymicrocirculation in visual cortexpentoxifyllineyoung shrs |
| spellingShingle | Mark B. Plotnikov Oleg I. Aliev Alexander Y. Shamanaev Anastasia V. Sidekhmenova Yana Anfinogenova Anna M. Anishchenko Tatiana I. Fomina Alexander M. Arkhipov Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development Clinical and Experimental Hypertension arterial blood pressure blood viscosity microcirculation in visual cortex pentoxifylline young shrs |
| title | Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development |
| title_full | Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development |
| title_fullStr | Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development |
| title_full_unstemmed | Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development |
| title_short | Effects of pentoxifylline on hemodynamic, hemorheological, and microcirculatory parameters in young SHRs during arterial hypertension development |
| title_sort | effects of pentoxifylline on hemodynamic hemorheological and microcirculatory parameters in young shrs during arterial hypertension development |
| topic | arterial blood pressure blood viscosity microcirculation in visual cortex pentoxifylline young shrs |
| url | http://dx.doi.org/10.1080/10641963.2017.1291662 |
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