Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint
Abstract Honokiol is a neolignan biphenol found in aerial parts of the Magnolia plant species. The Magnolia plant species traditionally belong to China and have been used for centuries to treat many pathological conditions. Honokiol mitigates the severity of several pathological conditions and has t...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Chinese Medicine |
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| Online Access: | https://doi.org/10.1186/s13020-023-00846-1 |
| _version_ | 1827633160611954688 |
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| author | Md. Faysal Jishan Khan Mehrukh Zehravi Nikhil Nath Laliteshwar Pratap Singh Saloni Kakkar Rajashekar Perusomula Pathan Amanulla Khan Firzan Nainu Mohammed Asiri Sharuk L. Khan Rajib Das Talha Bin Emran Polrat Wilairatana |
| author_facet | Md. Faysal Jishan Khan Mehrukh Zehravi Nikhil Nath Laliteshwar Pratap Singh Saloni Kakkar Rajashekar Perusomula Pathan Amanulla Khan Firzan Nainu Mohammed Asiri Sharuk L. Khan Rajib Das Talha Bin Emran Polrat Wilairatana |
| author_sort | Md. Faysal |
| collection | DOAJ |
| description | Abstract Honokiol is a neolignan biphenol found in aerial parts of the Magnolia plant species. The Magnolia plant species traditionally belong to China and have been used for centuries to treat many pathological conditions. Honokiol mitigates the severity of several pathological conditions and has the potential to work as an anti-inflammatory, anti-angiogenic, anticancer, antioxidant, and neurotherapeutic agent. It has a long history of being employed in the healthcare practices of Southeast Asia, but in recent years, a greater scope of research has been conducted on it. Plenty of experimental evidence suggests it could be beneficial as a neuroprotective bioactive molecule. Honokiol has several pharmacological effects, leading to its exploration as a potential therapy for neurological diseases (NDs), including Alzheimer's disease (AD), Parkinson’s disease (PD), cerebral ischemia, anxiety, depression, spinal cord injury, and so on. So, based on the previous experimentation reports, our goal is to discuss the neuroprotective properties of honokiol. Besides, honokiol derivatives have been highlighted recently as possible therapeutic options for NDs. So, this review focuses on honokiol's neurotherapeutic actions and toxicological profile to determine their safety and potential use in neurotherapeutics. |
| first_indexed | 2024-03-09T14:55:40Z |
| format | Article |
| id | doaj.art-e6e2d48787124781852e58bb956431d5 |
| institution | Directory Open Access Journal |
| issn | 1749-8546 |
| language | English |
| last_indexed | 2024-03-09T14:55:40Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj.art-e6e2d48787124781852e58bb956431d52023-11-26T14:13:50ZengBMCChinese Medicine1749-85462023-11-0118112210.1186/s13020-023-00846-1Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpointMd. Faysal0Jishan Khan1Mehrukh Zehravi2Nikhil Nath3Laliteshwar Pratap Singh4Saloni Kakkar5Rajashekar Perusomula6Pathan Amanulla Khan7Firzan Nainu8Mohammed Asiri9Sharuk L. Khan10Rajib Das11Talha Bin Emran12Polrat Wilairatana13Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International UniversityDepartment of Pharmacy, International Islamic University ChittagongDepartment of Clinical Pharmacy, College of Dentistry & Pharmacy, Buraydah Private CollegesDepartment of Pharmacy, International Islamic University ChittagongDepartment of Pharmaceutical Chemistry, Narayan Institute of Pharmacy, Gopal Narayan Singh UniversityDepartment of Pharmaceutical Sciences, Maharshi Dayanand UniversityCognitive Science Research Initiative Lab, Vishnu Institute of Pharmaceutical Education & ResearchDepartment of Pharmacy Practice, Anwar Ul Uloom College of PharmacyDepartment of Pharmacy, Faculty of Pharmacy, Hasanuddin UniversityDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid UniversityDepartment of Pharmaceutical Chemistry, N.B.S. Institute of PharmacyDepartment of Pharmacy, Faculty of Pharmacy, University of DhakaDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International UniversityDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol UniversityAbstract Honokiol is a neolignan biphenol found in aerial parts of the Magnolia plant species. The Magnolia plant species traditionally belong to China and have been used for centuries to treat many pathological conditions. Honokiol mitigates the severity of several pathological conditions and has the potential to work as an anti-inflammatory, anti-angiogenic, anticancer, antioxidant, and neurotherapeutic agent. It has a long history of being employed in the healthcare practices of Southeast Asia, but in recent years, a greater scope of research has been conducted on it. Plenty of experimental evidence suggests it could be beneficial as a neuroprotective bioactive molecule. Honokiol has several pharmacological effects, leading to its exploration as a potential therapy for neurological diseases (NDs), including Alzheimer's disease (AD), Parkinson’s disease (PD), cerebral ischemia, anxiety, depression, spinal cord injury, and so on. So, based on the previous experimentation reports, our goal is to discuss the neuroprotective properties of honokiol. Besides, honokiol derivatives have been highlighted recently as possible therapeutic options for NDs. So, this review focuses on honokiol's neurotherapeutic actions and toxicological profile to determine their safety and potential use in neurotherapeutics.https://doi.org/10.1186/s13020-023-00846-1HonokiolChinese HerbMagnolia speciesNeurological diseasesAlzheimer’s diseaseParkinson’s disease |
| spellingShingle | Md. Faysal Jishan Khan Mehrukh Zehravi Nikhil Nath Laliteshwar Pratap Singh Saloni Kakkar Rajashekar Perusomula Pathan Amanulla Khan Firzan Nainu Mohammed Asiri Sharuk L. Khan Rajib Das Talha Bin Emran Polrat Wilairatana Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint Chinese Medicine Honokiol Chinese Herb Magnolia species Neurological diseases Alzheimer’s disease Parkinson’s disease |
| title | Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint |
| title_full | Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint |
| title_fullStr | Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint |
| title_full_unstemmed | Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint |
| title_short | Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint |
| title_sort | neuropharmacological potential of honokiol and its derivatives from chinese herb magnolia species understandings from therapeutic viewpoint |
| topic | Honokiol Chinese Herb Magnolia species Neurological diseases Alzheimer’s disease Parkinson’s disease |
| url | https://doi.org/10.1186/s13020-023-00846-1 |
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