Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population
Mortality from cardiovascular diseases (CVDs) is higher in Russia compared to other European countries. High-sensitivity C-reactive protein (hs-CRP) is a biomarker of inflammation, and its elevated levels indicate increased CVD risks. We aim to describe the prevalence of low-grade systemic inflammat...
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| Format: | Article |
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MDPI AG
2023-05-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/5/835 |
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| author | Olga Mirolyubova Kamila Kholmatova Anna Postoeva Galina Kostrova Sofia Malyutina Alexander V. Kudryavtsev |
| author_facet | Olga Mirolyubova Kamila Kholmatova Anna Postoeva Galina Kostrova Sofia Malyutina Alexander V. Kudryavtsev |
| author_sort | Olga Mirolyubova |
| collection | DOAJ |
| description | Mortality from cardiovascular diseases (CVDs) is higher in Russia compared to other European countries. High-sensitivity C-reactive protein (hs-CRP) is a biomarker of inflammation, and its elevated levels indicate increased CVD risks. We aim to describe the prevalence of low-grade systemic inflammation (LGSI) and the associated factors in a Russian population. The Know Your Heart cross-sectional study was conducted in Arkhangelsk, Russia in 2015–2017 with a population sample aged 35–69 years (<i>n</i> = 2380). LGSI was defined as hs-CRP ≥ 2 and <10 mg/L, and its associations with socio-demographic, lifestyle, and cardiometabolic characteristics were analyzed. The prevalence of LGSI (age-standardized to European Standard Population 2013) was 34.1% (33.5% in men and 36.1% in women). In the total sample, the increased odds ratios (ORs) of LGSI were associated with abdominal obesity (2.1), smoking (1.9), dyslipidemia (1.5), pulmonary diseases (1.4), and hypertension (1.3); the decreased ORs were in women (0.6) and in married participants (0.6). In men, the ORs were higher with abdominal obesity (2.1), smoking (2.0), CVDs (1.5), and hazardous drinking (1.5); in women—with abdominal obesity (4.4) and pulmonary diseases (1.5). In conclusion, one-third of the adult population in Arkhangelsk had LGSI. Abdominal obesity was the strongest LGSI correlate in both sexes, while the profiles of other associated factors were different between men and women. |
| first_indexed | 2024-03-11T03:55:14Z |
| format | Article |
| id | doaj.art-e6e39093c96e4fc3ab7d1ab33851850a |
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| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T03:55:14Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-e6e39093c96e4fc3ab7d1ab33851850a2023-11-18T00:39:53ZengMDPI AGBiomolecules2218-273X2023-05-0113583510.3390/biom13050835Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult PopulationOlga Mirolyubova0Kamila Kholmatova1Anna Postoeva2Galina Kostrova3Sofia Malyutina4Alexander V. Kudryavtsev5Department of Faculty Therapy, Northern State Medical University, Arkhangelsk 163069, RussiaInternational Research Competence Centre, Northern State Medical University, Arkhangelsk 163069, RussiaDepartment of Hospital Therapy and Endocrinology, Northern State Medical University, Arkhangelsk 163069, RussiaDepartment of Normal Physiology, Northern State Medical University, Arkhangelsk 163069, RussiaResearch Institute of Internal and Preventive Medicine, Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630008, RussiaInternational Research Competence Centre, Northern State Medical University, Arkhangelsk 163069, RussiaMortality from cardiovascular diseases (CVDs) is higher in Russia compared to other European countries. High-sensitivity C-reactive protein (hs-CRP) is a biomarker of inflammation, and its elevated levels indicate increased CVD risks. We aim to describe the prevalence of low-grade systemic inflammation (LGSI) and the associated factors in a Russian population. The Know Your Heart cross-sectional study was conducted in Arkhangelsk, Russia in 2015–2017 with a population sample aged 35–69 years (<i>n</i> = 2380). LGSI was defined as hs-CRP ≥ 2 and <10 mg/L, and its associations with socio-demographic, lifestyle, and cardiometabolic characteristics were analyzed. The prevalence of LGSI (age-standardized to European Standard Population 2013) was 34.1% (33.5% in men and 36.1% in women). In the total sample, the increased odds ratios (ORs) of LGSI were associated with abdominal obesity (2.1), smoking (1.9), dyslipidemia (1.5), pulmonary diseases (1.4), and hypertension (1.3); the decreased ORs were in women (0.6) and in married participants (0.6). In men, the ORs were higher with abdominal obesity (2.1), smoking (2.0), CVDs (1.5), and hazardous drinking (1.5); in women—with abdominal obesity (4.4) and pulmonary diseases (1.5). In conclusion, one-third of the adult population in Arkhangelsk had LGSI. Abdominal obesity was the strongest LGSI correlate in both sexes, while the profiles of other associated factors were different between men and women.https://www.mdpi.com/2218-273X/13/5/835low-grade systemic inflammationhigh-sensitivity C-reactive proteinsocio-demographic factorslifestyleabdominal obesitydyslipidemia |
| spellingShingle | Olga Mirolyubova Kamila Kholmatova Anna Postoeva Galina Kostrova Sofia Malyutina Alexander V. Kudryavtsev Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population Biomolecules low-grade systemic inflammation high-sensitivity C-reactive protein socio-demographic factors lifestyle abdominal obesity dyslipidemia |
| title | Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population |
| title_full | Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population |
| title_fullStr | Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population |
| title_full_unstemmed | Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population |
| title_short | Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population |
| title_sort | socio demographic lifestyle and cardiometabolic characteristics associated with low grade systemic inflammation in russian adult population |
| topic | low-grade systemic inflammation high-sensitivity C-reactive protein socio-demographic factors lifestyle abdominal obesity dyslipidemia |
| url | https://www.mdpi.com/2218-273X/13/5/835 |
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