Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials
The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubilit...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/9/1146 |
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| author | Mazdida Sulaiman Khoshnur Jannat Veeranoot Nissapatorn Mohammed Rahmatullah Alok K. Paul Maria de Lourdes Pereira Mogana Rajagopal Monica Suleiman Mark S. Butler Mohammed Khaled Bin Break Jean-Frédéric Weber Polrat Wilairatana Christophe Wiart |
| author_facet | Mazdida Sulaiman Khoshnur Jannat Veeranoot Nissapatorn Mohammed Rahmatullah Alok K. Paul Maria de Lourdes Pereira Mogana Rajagopal Monica Suleiman Mark S. Butler Mohammed Khaled Bin Break Jean-Frédéric Weber Polrat Wilairatana Christophe Wiart |
| author_sort | Mazdida Sulaiman |
| collection | DOAJ |
| description | The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1979 to 2022. One hundred and forty-one antibacterial and/or antifungal alkaloids were identified during this period, mainly from basal angiosperms. The most active alkaloids are mainly planar, amphiphilic, with a molecular mass between 200 and 400 g/mol, and a polar surface area of about 50 Å<sup>2</sup>, and target DNA and/or topoisomerase as well as the cytoplasmic membrane. 8-Acetylnorchelerythrine, cryptolepine, 8-hydroxydihydrochelerythrine, 6-methoxydihydrosanguinarine, 2′-nortiliacorinine, pendulamine A and B, rhetsisine, sampangine, tiliacorine, tryptanthrin, tylophorinine, vallesamine, and viroallosecurinine yielded MIC ≤ 1 µg/mL and are candidates for the development of lead molecules. |
| first_indexed | 2024-03-10T00:56:13Z |
| format | Article |
| id | doaj.art-e6e3b2b2dedf489e806d129a3fd4a310 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T00:56:13Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-e6e3b2b2dedf489e806d129a3fd4a3102023-11-23T14:43:48ZengMDPI AGAntibiotics2079-63822022-08-01119114610.3390/antibiotics11091146Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical PotentialsMazdida Sulaiman0Khoshnur Jannat1Veeranoot Nissapatorn2Mohammed Rahmatullah3Alok K. Paul4Maria de Lourdes Pereira5Mogana Rajagopal6Monica Suleiman7Mark S. Butler8Mohammed Khaled Bin Break9Jean-Frédéric Weber10Polrat Wilairatana11Christophe Wiart12Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, MalaysiaDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, BangladeshSchool of Allied Health Sciences and World Union for Herbal Drug Discovery (WUHeDD), Walailak University, Nakhon Si Thammarat 80160, ThailandDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, BangladeshSchool of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7001, AustraliaCICECO-Aveiro Institute of Materials & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalFaculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, MalaysiaInstitute for Tropical Biology & Conservation, Universiti Malaysia Sabah, Kota Kinabalu 88400, MalaysiaMSBChem Consulting, Brisbane, QLD 4005, AustraliaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81411, Saudi ArabiaUFR Sciences Pharmaceutiques, INRAE, Bordeaux INP, UR ŒNOLOGIE, EA 4577, USC 1366, ISVV, Université de Bordeaux, 210 Chemin de Leysotte, 33882 Villenave d’Ornon, FranceDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, ThailandInstitute for Tropical Biology & Conservation, Universiti Malaysia Sabah, Kota Kinabalu 88400, MalaysiaThe emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1979 to 2022. One hundred and forty-one antibacterial and/or antifungal alkaloids were identified during this period, mainly from basal angiosperms. The most active alkaloids are mainly planar, amphiphilic, with a molecular mass between 200 and 400 g/mol, and a polar surface area of about 50 Å<sup>2</sup>, and target DNA and/or topoisomerase as well as the cytoplasmic membrane. 8-Acetylnorchelerythrine, cryptolepine, 8-hydroxydihydrochelerythrine, 6-methoxydihydrosanguinarine, 2′-nortiliacorinine, pendulamine A and B, rhetsisine, sampangine, tiliacorine, tryptanthrin, tylophorinine, vallesamine, and viroallosecurinine yielded MIC ≤ 1 µg/mL and are candidates for the development of lead molecules.https://www.mdpi.com/2079-6382/11/9/1146medicinal plantsantibacterialantifungalalkaloidsAsia |
| spellingShingle | Mazdida Sulaiman Khoshnur Jannat Veeranoot Nissapatorn Mohammed Rahmatullah Alok K. Paul Maria de Lourdes Pereira Mogana Rajagopal Monica Suleiman Mark S. Butler Mohammed Khaled Bin Break Jean-Frédéric Weber Polrat Wilairatana Christophe Wiart Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials Antibiotics medicinal plants antibacterial antifungal alkaloids Asia |
| title | Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials |
| title_full | Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials |
| title_fullStr | Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials |
| title_full_unstemmed | Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials |
| title_short | Antibacterial and Antifungal Alkaloids from Asian Angiosperms: Distribution, Mechanisms of Action, Structure-Activity, and Clinical Potentials |
| title_sort | antibacterial and antifungal alkaloids from asian angiosperms distribution mechanisms of action structure activity and clinical potentials |
| topic | medicinal plants antibacterial antifungal alkaloids Asia |
| url | https://www.mdpi.com/2079-6382/11/9/1146 |
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