Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistance

Hypoxia-induced autophagy as an additional mechanism in human osteosarcoma radioresistance

Osteosarcoma (OS) responds poorly to radiotherapy, but the mechanism is unclear. We found OS tumor tissues expressed high level of protein HIF-1α, a common biological marker indicative of hypoxia. It is known that hypoxic cells are generally radioresistant because of reduced production of irradiatio...

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Bibliographic Details
Main Authors: Helin Feng, Jin Wang, Wei Chen, Baoen Shan, Yin Guo, Jianfa Xu, Ling Wang, Peng Guo, Yingze Zhang
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of Bone Oncology
Subjects:
Osteosarcoma
Radioresistance
Hypoxia
Autophagy
HIF-1α
LC3
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137415300919

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