Synthesis, Characterization and Alpha Glucosidase Inhibition activity of new Phthalimide Derivatives
Three of imide intermediate products were synthesized by reacting of phthalic anhydride with glycine (2a), and tetrachloro phthalic anhydride with glycine , (S)-2-[(tert-Butoxycarbonyl)amino]-3-aminopropionic acid ( 2b,c) respectively in dry toluene with azeotropic removal of water using Dea...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2018-06-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/731 |
| _version_ | 1811209254582878208 |
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| author | Hassan ALi Mohammed H. Mohammed Sajida H. Ismeal |
| author_facet | Hassan ALi Mohammed H. Mohammed Sajida H. Ismeal |
| author_sort | Hassan ALi |
| collection | DOAJ |
| description |
Three of imide intermediate products were synthesized by reacting of phthalic anhydride with glycine (2a), and tetrachloro phthalic anhydride with glycine , (S)-2-[(tert-Butoxycarbonyl)amino]-3-aminopropionic acid ( 2b,c) respectively in dry toluene with azeotropic removal of water using Dean- stark apparatus then carboxyl functional group activated by refluxing with thionyl chloride, the resulted acid chloride (3a-c) were reacted with different amine (5-flourouracil, 4-chloroaniline, 4-bromoaniline, 2-amino thiazole, and pyrrolidine) (4a-e) , the resulted products consider as the end products (5a-j) while the compounds (5k-o) required further reaction to deprotect aliphatic amine this achieved by treating the compounds with TFA to remove tert-Butoxycarbonyl group (6a-e).
The alpha glucosidase inhibitory activity of some synthesized compounds (5a, 5f, 6a) were tested by using -glucosidase from Saccharomyces cerevisiae, p-nitrophenol glucopyranoside (pNPG) used as substrate and acarbose used as standard.
All these test compounds shows excellent inhibitory activity according to IC50 values which is ranging from (4.61-7.32).
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| first_indexed | 2024-04-12T04:35:08Z |
| format | Article |
| id | doaj.art-e6e4a23cf3c14ec8bc9c997854e07b90 |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-04-12T04:35:08Z |
| publishDate | 2018-06-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-e6e4a23cf3c14ec8bc9c997854e07b902022-12-22T03:47:49ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972018-06-0127110.31351/vol27iss1pp100-108731Synthesis, Characterization and Alpha Glucosidase Inhibition activity of new Phthalimide DerivativesHassan ALi0Mohammed H. MohammedSajida H. Ismealcollege of pharmacy al-mustansiryia university Three of imide intermediate products were synthesized by reacting of phthalic anhydride with glycine (2a), and tetrachloro phthalic anhydride with glycine , (S)-2-[(tert-Butoxycarbonyl)amino]-3-aminopropionic acid ( 2b,c) respectively in dry toluene with azeotropic removal of water using Dean- stark apparatus then carboxyl functional group activated by refluxing with thionyl chloride, the resulted acid chloride (3a-c) were reacted with different amine (5-flourouracil, 4-chloroaniline, 4-bromoaniline, 2-amino thiazole, and pyrrolidine) (4a-e) , the resulted products consider as the end products (5a-j) while the compounds (5k-o) required further reaction to deprotect aliphatic amine this achieved by treating the compounds with TFA to remove tert-Butoxycarbonyl group (6a-e). The alpha glucosidase inhibitory activity of some synthesized compounds (5a, 5f, 6a) were tested by using -glucosidase from Saccharomyces cerevisiae, p-nitrophenol glucopyranoside (pNPG) used as substrate and acarbose used as standard. All these test compounds shows excellent inhibitory activity according to IC50 values which is ranging from (4.61-7.32). https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/731 |
| spellingShingle | Hassan ALi Mohammed H. Mohammed Sajida H. Ismeal Synthesis, Characterization and Alpha Glucosidase Inhibition activity of new Phthalimide Derivatives Iraqi Journal of Pharmaceutical Sciences |
| title | Synthesis, Characterization and Alpha Glucosidase Inhibition activity of new Phthalimide Derivatives |
| title_full | Synthesis, Characterization and Alpha Glucosidase Inhibition activity of new Phthalimide Derivatives |
| title_fullStr | Synthesis, Characterization and Alpha Glucosidase Inhibition activity of new Phthalimide Derivatives |
| title_full_unstemmed | Synthesis, Characterization and Alpha Glucosidase Inhibition activity of new Phthalimide Derivatives |
| title_short | Synthesis, Characterization and Alpha Glucosidase Inhibition activity of new Phthalimide Derivatives |
| title_sort | synthesis characterization and alpha glucosidase inhibition activity of new phthalimide derivatives |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/731 |
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