Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications
Abstract Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-constant αβ chain of T-cell receptor (TCR) and recognize microbe-derived vitamin B metabolites via major histocompatibility complex class I related-1 molecule (MR1). MAIT...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Journal of Inflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12950-024-00376-z |
| _version_ | 1827328640269942784 |
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| author | Xue Lin Ye Wang Yanqi He |
| author_facet | Xue Lin Ye Wang Yanqi He |
| author_sort | Xue Lin |
| collection | DOAJ |
| description | Abstract Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-constant αβ chain of T-cell receptor (TCR) and recognize microbe-derived vitamin B metabolites via major histocompatibility complex class I related-1 molecule (MR1). MAIT cells get activated mainly through unique TCR-dependent and TCR-independent pathways, and express multiple functional and phenotypic traits, including innate-like functionality, T helper (Th) 1 cell immunity, Th 17 cell immunity, and tissue homing. Given the functions, MAIT cells are extensively reported to play a key role in mucosal homeostasis and infectious diseases. In the current work, we review the basic characteristics of MAIT cells and their roles in mucosal homeostasis and development of respiratory infectious diseases as well as their potential therapeutic targets. |
| first_indexed | 2024-03-07T15:20:26Z |
| format | Article |
| id | doaj.art-e6e50af59f874b1f964f2956513a525c |
| institution | Directory Open Access Journal |
| issn | 1476-9255 |
| language | English |
| last_indexed | 2024-03-07T15:20:26Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj.art-e6e50af59f874b1f964f2956513a525c2024-03-05T17:41:13ZengBMCJournal of Inflammation1476-92552024-02-0121111110.1186/s12950-024-00376-zMucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applicationsXue Lin0Ye Wang1Yanqi He2Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityDepartment of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan UniversityAbstract Mucosal-associated invariant T (MAIT) cells are an atypical subset of T lymphocytes, which have a highly conserved semi-constant αβ chain of T-cell receptor (TCR) and recognize microbe-derived vitamin B metabolites via major histocompatibility complex class I related-1 molecule (MR1). MAIT cells get activated mainly through unique TCR-dependent and TCR-independent pathways, and express multiple functional and phenotypic traits, including innate-like functionality, T helper (Th) 1 cell immunity, Th 17 cell immunity, and tissue homing. Given the functions, MAIT cells are extensively reported to play a key role in mucosal homeostasis and infectious diseases. In the current work, we review the basic characteristics of MAIT cells and their roles in mucosal homeostasis and development of respiratory infectious diseases as well as their potential therapeutic targets.https://doi.org/10.1186/s12950-024-00376-zMAIT1MR125-OP-RU3Immune barrier4Infectious diseases5 |
| spellingShingle | Xue Lin Ye Wang Yanqi He Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications Journal of Inflammation MAIT1 MR12 5-OP-RU3 Immune barrier4 Infectious diseases5 |
| title | Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications |
| title_full | Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications |
| title_fullStr | Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications |
| title_full_unstemmed | Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications |
| title_short | Mucosal-associated invariant T cells in infectious diseases of respiratory system: recent advancements and applications |
| title_sort | mucosal associated invariant t cells in infectious diseases of respiratory system recent advancements and applications |
| topic | MAIT1 MR12 5-OP-RU3 Immune barrier4 Infectious diseases5 |
| url | https://doi.org/10.1186/s12950-024-00376-z |
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