Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver

Scopolin ameliorates high-fat diet induced hepatic steatosis in mice: potential involvement of SIRT1-mediated signaling cascades in the liver

Abstract The present study aimed to investigate whether scopolin exhibits beneficial effects on high-fat diet (HFD)-induced hepatic steatosis in mice. The involvement of sirtuin 1 (SIRT1) as a molecular target for scopolin was also explored. Scopolin decreased the Km of SIRT1 for p53 and nicotinamid...

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Bibliographic Details
Main Authors:	Ahyoung Yoo, Vikram P. Narayan, Eun Young Hong, Wan Kyunn Whang, Taesun Park
Format:	Article
Language:	English
Published:	Nature Portfolio 2017-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-017-02416-6

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