Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China
CONTEXT AND OBJECTIVE: Dimethylarginine dimethylaminohydrolase enzymes (DDAH), which are encoded by the genes DDAH1 and DDAH2, play a fundamental role in maintaining endothelial function. We conducted a case-control study on a Chinese population that included three ethnic groups (Han, Kazakh and Uy...
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000300205&lng=en&tlng=en |
| _version_ | 1818701032557903872 |
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| author | Zhong Wang Shaoze Chen Lina Zhang Guilin Lu Chengming Zhou Dao Wen Wang Li Wang Bayinbate Badengmu Zhihong Zhai Lian Qin |
| author_facet | Zhong Wang Shaoze Chen Lina Zhang Guilin Lu Chengming Zhou Dao Wen Wang Li Wang Bayinbate Badengmu Zhihong Zhai Lian Qin |
| author_sort | Zhong Wang |
| collection | DOAJ |
| description | CONTEXT AND OBJECTIVE: Dimethylarginine dimethylaminohydrolase enzymes (DDAH), which are encoded by the genes DDAH1 and DDAH2, play a fundamental role in maintaining endothelial function. We conducted a case-control study on a Chinese population that included three ethnic groups (Han, Kazakh and Uygur), to systemically investigate associations between variations in the genes DDAH1 and DDAH2 and hypertension. DESIGN AND SETTING: Experimental study at the Department of Internal Medicine and Genetic Diagnosis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. METHODS: This case-control study included 1,224 patients with hypertension and 967 healthy unrelated individuals as controls. DDAH1 -396 4N (GCGT) del>ins, rs3087894, rs805304 and rs9267551 were genotyped using the TaqMan 5' nuclease assay. RESULTS: The G/C genotype of rs3087894 in DDAH1 was a risk factor for hypertension in the Kazakh group in the co-dominant model (G/C versus G/G) (OR 1.39; 95% CI: 1.02-1.88; P < 0.05), with the same result in the dominant model (G/C + C/C versus G/G) (OR 1.38; 95% CI: 1.03-1.84; P < 0.05). In contrast, the C/C genotype of rs3087894 seemed to be a protective factor against hypertension in the Uygur group in the recessive model (C/C versus G/G + G/C) (OR 0.62; 95% CI: 0.39- 0.97; P < 0.05). Similar findings for rs3087894 were also observed after adjusting the variable for the age covariate. CONCLUSION: Our results indicated that the C-allele of rs3087894 in DDAH1 was a risk factor for hypertension in the Kazakh group but a protective factor in the Uygur group. |
| first_indexed | 2024-12-17T15:14:23Z |
| format | Article |
| id | doaj.art-e6e753816ff44b3f9ee4bc2d2e2ef8c9 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-17T15:14:23Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-e6e753816ff44b3f9ee4bc2d2e2ef8c92022-12-21T21:43:35ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460134320521010.1590/1516-3180.2015.01150108S1516-31802016000300205Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in ChinaZhong WangShaoze ChenLina ZhangGuilin LuChengming ZhouDao Wen WangLi WangBayinbate BadengmuZhihong ZhaiLian QinCONTEXT AND OBJECTIVE: Dimethylarginine dimethylaminohydrolase enzymes (DDAH), which are encoded by the genes DDAH1 and DDAH2, play a fundamental role in maintaining endothelial function. We conducted a case-control study on a Chinese population that included three ethnic groups (Han, Kazakh and Uygur), to systemically investigate associations between variations in the genes DDAH1 and DDAH2 and hypertension. DESIGN AND SETTING: Experimental study at the Department of Internal Medicine and Genetic Diagnosis, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. METHODS: This case-control study included 1,224 patients with hypertension and 967 healthy unrelated individuals as controls. DDAH1 -396 4N (GCGT) del>ins, rs3087894, rs805304 and rs9267551 were genotyped using the TaqMan 5' nuclease assay. RESULTS: The G/C genotype of rs3087894 in DDAH1 was a risk factor for hypertension in the Kazakh group in the co-dominant model (G/C versus G/G) (OR 1.39; 95% CI: 1.02-1.88; P < 0.05), with the same result in the dominant model (G/C + C/C versus G/G) (OR 1.38; 95% CI: 1.03-1.84; P < 0.05). In contrast, the C/C genotype of rs3087894 seemed to be a protective factor against hypertension in the Uygur group in the recessive model (C/C versus G/G + G/C) (OR 0.62; 95% CI: 0.39- 0.97; P < 0.05). Similar findings for rs3087894 were also observed after adjusting the variable for the age covariate. CONCLUSION: Our results indicated that the C-allele of rs3087894 in DDAH1 was a risk factor for hypertension in the Kazakh group but a protective factor in the Uygur group.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000300205&lng=en&tlng=enCardiovascular systemBlood pressureHypertensionGenesPolymorphism, Genetic |
| spellingShingle | Zhong Wang Shaoze Chen Lina Zhang Guilin Lu Chengming Zhou Dao Wen Wang Li Wang Bayinbate Badengmu Zhihong Zhai Lian Qin Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China São Paulo Medical Journal Cardiovascular system Blood pressure Hypertension Genes Polymorphism, Genetic |
| title | Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China |
| title_full | Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China |
| title_fullStr | Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China |
| title_full_unstemmed | Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China |
| title_short | Association between variation in the genes DDAH1 and DDAH2 and hypertension among Uygur, Kazakh and Han ethnic groups in China |
| title_sort | association between variation in the genes ddah1 and ddah2 and hypertension among uygur kazakh and han ethnic groups in china |
| topic | Cardiovascular system Blood pressure Hypertension Genes Polymorphism, Genetic |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802016000300205&lng=en&tlng=en |
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