Macrophage polarization states in atherosclerosis
Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of inflammatory responses. They are involved in all stages of atherosclerosis development and progression, from plaque formatio...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185587/full |
| _version_ | 1797834703037792256 |
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| author | Jiayong Wu Shengping He Zhengkun Song Sikai Chen Xuefeng Lin Huimei Sun Pengyu Zhou Qinbao Peng Songlin Du Shaoyi Zheng Xiu Liu |
| author_facet | Jiayong Wu Shengping He Zhengkun Song Sikai Chen Xuefeng Lin Huimei Sun Pengyu Zhou Qinbao Peng Songlin Du Shaoyi Zheng Xiu Liu |
| author_sort | Jiayong Wu |
| collection | DOAJ |
| description | Atherosclerosis, a chronic inflammatory condition primarily affecting large and medium arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of inflammatory responses. They are involved in all stages of atherosclerosis development and progression, from plaque formation to transition into vulnerable plaques, and are considered important therapeutic targets. Increasing evidence suggests that the modulation of macrophage polarization can effectively control the progression of atherosclerosis. Herein, we explore the role of macrophage polarization in the progression of atherosclerosis and summarize emerging therapies for the regulation of macrophage polarization. Thus, the aim is to inspire new avenues of research in disease mechanisms and clinical prevention and treatment of atherosclerosis. |
| first_indexed | 2024-04-09T14:42:53Z |
| format | Article |
| id | doaj.art-e6e79f3565024da58768dc74d72a0cd1 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-09T14:42:53Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e6e79f3565024da58768dc74d72a0cd12023-05-03T05:27:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-05-011410.3389/fimmu.2023.11855871185587Macrophage polarization states in atherosclerosisJiayong WuShengping HeZhengkun SongSikai ChenXuefeng LinHuimei SunPengyu ZhouQinbao PengSonglin DuShaoyi ZhengXiu LiuAtherosclerosis, a chronic inflammatory condition primarily affecting large and medium arteries, is the main cause of cardiovascular diseases. Macrophages are key mediators of inflammatory responses. They are involved in all stages of atherosclerosis development and progression, from plaque formation to transition into vulnerable plaques, and are considered important therapeutic targets. Increasing evidence suggests that the modulation of macrophage polarization can effectively control the progression of atherosclerosis. Herein, we explore the role of macrophage polarization in the progression of atherosclerosis and summarize emerging therapies for the regulation of macrophage polarization. Thus, the aim is to inspire new avenues of research in disease mechanisms and clinical prevention and treatment of atherosclerosis.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185587/fullatherosclerosismacrophage polarizationbiomoleculesinflammationphenotype |
| spellingShingle | Jiayong Wu Shengping He Zhengkun Song Sikai Chen Xuefeng Lin Huimei Sun Pengyu Zhou Qinbao Peng Songlin Du Shaoyi Zheng Xiu Liu Macrophage polarization states in atherosclerosis Frontiers in Immunology atherosclerosis macrophage polarization biomolecules inflammation phenotype |
| title | Macrophage polarization states in atherosclerosis |
| title_full | Macrophage polarization states in atherosclerosis |
| title_fullStr | Macrophage polarization states in atherosclerosis |
| title_full_unstemmed | Macrophage polarization states in atherosclerosis |
| title_short | Macrophage polarization states in atherosclerosis |
| title_sort | macrophage polarization states in atherosclerosis |
| topic | atherosclerosis macrophage polarization biomolecules inflammation phenotype |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1185587/full |
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