Diagnostic Value of Endometrial Nerves in the Endometrial Tissue of Patients with Endometriosis
INTRODUCTION[|]The aim of the present study was to determine the density of nerve fibers in the functional layer of the endometrium in patients with endometriosis in order to determine if it could be used as a minimally invasive diagnostic method for endometriosis. A secondary goal was to assess the...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2018-01-01
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| Series: | Southern Clinics of Istanbul Eurasia |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-96168 |
| _version_ | 1797906987144445952 |
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| author | Yaren Tuba Bektaş Önder Sakin Zehra Meltem Pirimoğlu Aylin Onan Yilmaz Kayhan Basak Esra Esim Büyükbayrak Sadullah Ozkan Engin Ersin Simsek |
| author_facet | Yaren Tuba Bektaş Önder Sakin Zehra Meltem Pirimoğlu Aylin Onan Yilmaz Kayhan Basak Esra Esim Büyükbayrak Sadullah Ozkan Engin Ersin Simsek |
| author_sort | Yaren Tuba Bektaş |
| collection | DOAJ |
| description | INTRODUCTION[|]The aim of the present study was to determine the density of nerve fibers in the functional layer of the endometrium in patients with endometriosis in order to determine if it could be used as a minimally invasive diagnostic method for endometriosis. A secondary goal was to assess the relationship between the severity of pelvic pain due to endometriosis and the density of nerve fibers in endometrial sampling materials.[¤]METHODS[|]Endometrial sampling was performed in 67 patients who presented at the hospital between August 2011 and November 2012. Endometriosis was diagnosed by surgical histopathological examination. A total of 34 patients diagnosed with endometriosis were selected as the study group. Thirty-three patients who were operated on for benign conditions other than endometriosis were selected as a control group. Immunohistochemical detection of the nerve fiber marker protein gene product 9.5 (PGP 9.5) was used to analyze the endometrial samples for nerve fibers. Visual Analogue Scale scores were used to evaluate the correlation between nerve fiber density and the severity of pelvic pain. Statistical analyses were calculated with SPSS Statistics for Windows, Version 17.0 (SPSS, Inc., Chicago, IL, USA).[¤]RESULTS[|]The mean density of nerve fibers was 1.85+-1.74 fibers/mm2 in the endometriosis group. In the control group, the mean density was 1.15+-1.48 fibers/mm2. There was no statistically significant difference between the groups (p=0.08). The pelvic pain score did not correlate with PGP 9.5 intensity.
[¤]DISCUSSION AND CONCLUSION[|]The detection and measurement of nerve fibers in the eutopic endometrium using the PGP 9.5 marker was not found to be a decisive noninvasive method to diagnose endometriosis.[¤] |
| first_indexed | 2024-04-10T10:29:21Z |
| format | Article |
| id | doaj.art-e6e7aa174e8a4ed98f3c2f893d822c51 |
| institution | Directory Open Access Journal |
| issn | 2587-0998 |
| language | English |
| last_indexed | 2024-04-10T10:29:21Z |
| publishDate | 2018-01-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Southern Clinics of Istanbul Eurasia |
| spelling | doaj.art-e6e7aa174e8a4ed98f3c2f893d822c512023-02-15T16:21:12ZengKARE PublishingSouthern Clinics of Istanbul Eurasia2587-09982018-01-0128426126510.14744/scie.2018.96168SCIE-96168Diagnostic Value of Endometrial Nerves in the Endometrial Tissue of Patients with EndometriosisYaren Tuba Bektaş0Önder Sakin1Zehra Meltem Pirimoğlu2Aylin Onan Yilmaz3Kayhan Basak4Esra Esim Büyükbayrak5Sadullah Ozkan6Engin Ersin Simsek7Department of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyDepartment of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyDepartment of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyDepartment of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyDepartment of Pathology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyDepartment of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyDepartment of Obstetrics and Gynecology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyDepartment of Family Medicine, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, TurkeyINTRODUCTION[|]The aim of the present study was to determine the density of nerve fibers in the functional layer of the endometrium in patients with endometriosis in order to determine if it could be used as a minimally invasive diagnostic method for endometriosis. A secondary goal was to assess the relationship between the severity of pelvic pain due to endometriosis and the density of nerve fibers in endometrial sampling materials.[¤]METHODS[|]Endometrial sampling was performed in 67 patients who presented at the hospital between August 2011 and November 2012. Endometriosis was diagnosed by surgical histopathological examination. A total of 34 patients diagnosed with endometriosis were selected as the study group. Thirty-three patients who were operated on for benign conditions other than endometriosis were selected as a control group. Immunohistochemical detection of the nerve fiber marker protein gene product 9.5 (PGP 9.5) was used to analyze the endometrial samples for nerve fibers. Visual Analogue Scale scores were used to evaluate the correlation between nerve fiber density and the severity of pelvic pain. Statistical analyses were calculated with SPSS Statistics for Windows, Version 17.0 (SPSS, Inc., Chicago, IL, USA).[¤]RESULTS[|]The mean density of nerve fibers was 1.85+-1.74 fibers/mm2 in the endometriosis group. In the control group, the mean density was 1.15+-1.48 fibers/mm2. There was no statistically significant difference between the groups (p=0.08). The pelvic pain score did not correlate with PGP 9.5 intensity. [¤]DISCUSSION AND CONCLUSION[|]The detection and measurement of nerve fibers in the eutopic endometrium using the PGP 9.5 marker was not found to be a decisive noninvasive method to diagnose endometriosis.[¤]https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-96168endometriosisimmunohistochemistrynerve fibers. |
| spellingShingle | Yaren Tuba Bektaş Önder Sakin Zehra Meltem Pirimoğlu Aylin Onan Yilmaz Kayhan Basak Esra Esim Büyükbayrak Sadullah Ozkan Engin Ersin Simsek Diagnostic Value of Endometrial Nerves in the Endometrial Tissue of Patients with Endometriosis Southern Clinics of Istanbul Eurasia endometriosis immunohistochemistry nerve fibers. |
| title | Diagnostic Value of Endometrial Nerves in the Endometrial Tissue of Patients with Endometriosis |
| title_full | Diagnostic Value of Endometrial Nerves in the Endometrial Tissue of Patients with Endometriosis |
| title_fullStr | Diagnostic Value of Endometrial Nerves in the Endometrial Tissue of Patients with Endometriosis |
| title_full_unstemmed | Diagnostic Value of Endometrial Nerves in the Endometrial Tissue of Patients with Endometriosis |
| title_short | Diagnostic Value of Endometrial Nerves in the Endometrial Tissue of Patients with Endometriosis |
| title_sort | diagnostic value of endometrial nerves in the endometrial tissue of patients with endometriosis |
| topic | endometriosis immunohistochemistry nerve fibers. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=scie&un=SCIE-96168 |
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