Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of China
ObjectivesTo report the first series of testicular sex cord-stromal tumors (TSCSTs) with detailed clinicopathologic findings and long-term follow-up in the Chinese population.Patients and MethodsFrom 2008 to 2018, 15 patients with TSCST were included in our study. The tumors were analyzed for epidem...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.816012/full |
| _version_ | 1811231638112174080 |
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| author | Yin Huang Yin Huang Bo Chen Dehong Cao Zeyu Chen Jin Li Jianbing Guo Qiang Dong Qiang Wei Liangren Liu |
| author_facet | Yin Huang Yin Huang Bo Chen Dehong Cao Zeyu Chen Jin Li Jianbing Guo Qiang Dong Qiang Wei Liangren Liu |
| author_sort | Yin Huang |
| collection | DOAJ |
| description | ObjectivesTo report the first series of testicular sex cord-stromal tumors (TSCSTs) with detailed clinicopathologic findings and long-term follow-up in the Chinese population.Patients and MethodsFrom 2008 to 2018, 15 patients with TSCST were included in our study. The tumors were analyzed for epidemiological parameters, clinical characteristics, tumor markers, therapy, and follow-up data.ResultsThe median age of the patients was 28 years (range, 13–80 years). Para-aortic lymph node metastases were detected in 2 patients after radiological evaluation. Orchiectomy was performed in all patients, and the median diameter of the tumor was 1.5 cm (range, 0.5–5.0 cm). Nine Leydig cell tumors (LCTs), 5 Sertoli cell tumors (SCTs), and 1 unclassified type were confirmed after pathologic evaluation. Thirteen patients (86.7%) were categorized as stage I, and 2 patients (13.3%) were categorized as stage II. The median clinical follow-up was 39.0 months (range, 5–97 months), which showed 10 alive patients, such as 1 patient with progression at 40 months after orchiectomy. The 3- and 5-year progression-free survivals were 100 and 90.0%, respectively.ConclusionTesticular sex cord-stromal tumor at stages I and II is a rare subtype with benign behavior and a favorable prognosis in the Chinese population. However, lymph node metastases may be the dominant risk factor for patients with TSCST. |
| first_indexed | 2024-04-12T10:48:30Z |
| format | Article |
| id | doaj.art-e6e8886b911749f596271b507076d071 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-12T10:48:30Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-e6e8886b911749f596271b507076d0712022-12-22T03:36:21ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-05-01910.3389/fmed.2022.816012816012Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of ChinaYin Huang0Yin Huang1Bo Chen2Dehong Cao3Zeyu Chen4Jin Li5Jianbing Guo6Qiang Dong7Qiang Wei8Liangren Liu9Department of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, ChinaWest China School of Medicine, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, ChinaDepartment of Urology, West China Hospital, Institute of Urology, Sichuan University, Chengdu, ChinaObjectivesTo report the first series of testicular sex cord-stromal tumors (TSCSTs) with detailed clinicopathologic findings and long-term follow-up in the Chinese population.Patients and MethodsFrom 2008 to 2018, 15 patients with TSCST were included in our study. The tumors were analyzed for epidemiological parameters, clinical characteristics, tumor markers, therapy, and follow-up data.ResultsThe median age of the patients was 28 years (range, 13–80 years). Para-aortic lymph node metastases were detected in 2 patients after radiological evaluation. Orchiectomy was performed in all patients, and the median diameter of the tumor was 1.5 cm (range, 0.5–5.0 cm). Nine Leydig cell tumors (LCTs), 5 Sertoli cell tumors (SCTs), and 1 unclassified type were confirmed after pathologic evaluation. Thirteen patients (86.7%) were categorized as stage I, and 2 patients (13.3%) were categorized as stage II. The median clinical follow-up was 39.0 months (range, 5–97 months), which showed 10 alive patients, such as 1 patient with progression at 40 months after orchiectomy. The 3- and 5-year progression-free survivals were 100 and 90.0%, respectively.ConclusionTesticular sex cord-stromal tumor at stages I and II is a rare subtype with benign behavior and a favorable prognosis in the Chinese population. However, lymph node metastases may be the dominant risk factor for patients with TSCST.https://www.frontiersin.org/articles/10.3389/fmed.2022.816012/fulltestistesticular neoplasmssex cord-stromal tumorsfollow-uporchiectomy |
| spellingShingle | Yin Huang Yin Huang Bo Chen Dehong Cao Zeyu Chen Jin Li Jianbing Guo Qiang Dong Qiang Wei Liangren Liu Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of China Frontiers in Medicine testis testicular neoplasms sex cord-stromal tumors follow-up orchiectomy |
| title | Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of China |
| title_full | Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of China |
| title_fullStr | Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of China |
| title_full_unstemmed | Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of China |
| title_short | Sex Cord-Stromal Tumors of Testis: A Clinicopathologic and Follow-Up Study of 15 Cases in a High-Volume Institute of China |
| title_sort | sex cord stromal tumors of testis a clinicopathologic and follow up study of 15 cases in a high volume institute of china |
| topic | testis testicular neoplasms sex cord-stromal tumors follow-up orchiectomy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.816012/full |
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