Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers
Summary: RNA-binding proteins (RBPs) regulate the expression of thousands of transcripts, and some are reported to be involved in human tumorigenesis. However, little is known about the dysregulation of RBPs at the genomic level in human cancers. Here, we conducted comprehensive analyses for express...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717318442 |
| _version_ | 1818563313317969920 |
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| author | Ze-Lin Wang Bin Li Yu-Xia Luo Qiao Lin Shu-Rong Liu Xiao-Qin Zhang Hui Zhou Jian-Hua Yang Liang-Hu Qu |
| author_facet | Ze-Lin Wang Bin Li Yu-Xia Luo Qiao Lin Shu-Rong Liu Xiao-Qin Zhang Hui Zhou Jian-Hua Yang Liang-Hu Qu |
| author_sort | Ze-Lin Wang |
| collection | DOAJ |
| description | Summary: RNA-binding proteins (RBPs) regulate the expression of thousands of transcripts, and some are reported to be involved in human tumorigenesis. However, little is known about the dysregulation of RBPs at the genomic level in human cancers. Here, we conducted comprehensive analyses for expression, somatic copy number alteration (SCNA), and mutation profiles of 1,542 RBPs in ∼7,000 clinical specimens across 15 cancer types. We identified markedly dysregulated RBPs and found that downregulation was a predominant pattern in cancer. Combined with recurrent SCNA data, we identified 76 RBPs as potential drivers. We also discovered a set of 139 RBPs that were significantly mutated in cancers. We confirmed the oncogenic property of six RBPs in colorectal and liver cancer cell lines by using in vitro functional experiments. Our study highlights the potential roles of RBPs in carcinogenesis and lays the groundwork to better understand the functions and mechanisms of RBPs in cancer. : Wang et al. characterize transcriptional and genomic alterations in the landscape of RNA-binding proteins (RBPs) in ∼7,000 clinical samples across 15 human cancer types and experimentally validate the effects of several cancer-related RBPs on cell viability. Keywords: RNA-binding proteins, dysregulation, somatic copy number alterations, mutation profile, cancer driver |
| first_indexed | 2024-12-14T01:15:02Z |
| format | Article |
| id | doaj.art-e6e8d395d2344266939dc7fb227d30ce |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-14T01:15:02Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-e6e8d395d2344266939dc7fb227d30ce2022-12-21T23:22:38ZengElsevierCell Reports2211-12472018-01-01221286298Comprehensive Genomic Characterization of RNA-Binding Proteins across Human CancersZe-Lin Wang0Bin Li1Yu-Xia Luo2Qiao Lin3Shu-Rong Liu4Xiao-Qin Zhang5Hui Zhou6Jian-Hua Yang7Liang-Hu Qu8Key Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China; State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, ChinaKey Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China; State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, ChinaKey Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China; State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, ChinaKey Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China; State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, ChinaKey Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China; State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, ChinaSchool of Medicine, South China University of Technology, Guangzhou 510275, China; Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, ChinaKey Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China; State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, ChinaKey Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China; State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, China; Corresponding authorKey Laboratory of Gene Engineering of the Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China; State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, China; Corresponding authorSummary: RNA-binding proteins (RBPs) regulate the expression of thousands of transcripts, and some are reported to be involved in human tumorigenesis. However, little is known about the dysregulation of RBPs at the genomic level in human cancers. Here, we conducted comprehensive analyses for expression, somatic copy number alteration (SCNA), and mutation profiles of 1,542 RBPs in ∼7,000 clinical specimens across 15 cancer types. We identified markedly dysregulated RBPs and found that downregulation was a predominant pattern in cancer. Combined with recurrent SCNA data, we identified 76 RBPs as potential drivers. We also discovered a set of 139 RBPs that were significantly mutated in cancers. We confirmed the oncogenic property of six RBPs in colorectal and liver cancer cell lines by using in vitro functional experiments. Our study highlights the potential roles of RBPs in carcinogenesis and lays the groundwork to better understand the functions and mechanisms of RBPs in cancer. : Wang et al. characterize transcriptional and genomic alterations in the landscape of RNA-binding proteins (RBPs) in ∼7,000 clinical samples across 15 human cancer types and experimentally validate the effects of several cancer-related RBPs on cell viability. Keywords: RNA-binding proteins, dysregulation, somatic copy number alterations, mutation profile, cancer driverhttp://www.sciencedirect.com/science/article/pii/S2211124717318442 |
| spellingShingle | Ze-Lin Wang Bin Li Yu-Xia Luo Qiao Lin Shu-Rong Liu Xiao-Qin Zhang Hui Zhou Jian-Hua Yang Liang-Hu Qu Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers Cell Reports |
| title | Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers |
| title_full | Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers |
| title_fullStr | Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers |
| title_full_unstemmed | Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers |
| title_short | Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers |
| title_sort | comprehensive genomic characterization of rna binding proteins across human cancers |
| url | http://www.sciencedirect.com/science/article/pii/S2211124717318442 |
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