<i>Allium</i> Flavonols: Health Benefits, Molecular Targets, and Bioavailability
<i>Allium</i> species are revered worldwide as vegetables, condiments, and spices as well as the therapeutic agents in traditional medicine. The bioactive compounds in alliums mainly include organosulfur compounds, polyphenols, dietary fibers, and saponins. Flavonoids, particularly flavo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-09-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/9/9/888 |
| _version_ | 1797553206994141184 |
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| author | Damini Kothari Woo-Do Lee Soo-Ki Kim |
| author_facet | Damini Kothari Woo-Do Lee Soo-Ki Kim |
| author_sort | Damini Kothari |
| collection | DOAJ |
| description | <i>Allium</i> species are revered worldwide as vegetables, condiments, and spices as well as the therapeutic agents in traditional medicine. The bioactive compounds in alliums mainly include organosulfur compounds, polyphenols, dietary fibers, and saponins. Flavonoids, particularly flavonols from alliums, have been demonstrated to have the antioxidant, anticancer, hypolipidemic, anti-diabetic, cardioprotective, neuroprotective, and antimicrobial activities. However, flavonols are mostly characterized from onions and have not been comprehensively reviewed across different species. This article therefore focuses on flavonol profiles from different <i>Allium</i> species, their health effects, underlying molecular mechanisms, and bioavailability. Intriguingly, the functional health effects of flavonols were mainly ascribed to their antioxidant and anti-inflammatory activities involving a cascade of multiple signaling pathways. Although the <i>Allium</i>-derived flavonols offer tremendous potential in preventing chronic disease risks, in-depth studies are needed to translate their clinical application. |
| first_indexed | 2024-03-10T16:13:07Z |
| format | Article |
| id | doaj.art-e6e9c04ae0f64d83a167f4a0aecc88d8 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T16:13:07Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e6e9c04ae0f64d83a167f4a0aecc88d82023-11-20T14:21:36ZengMDPI AGAntioxidants2076-39212020-09-019988810.3390/antiox9090888<i>Allium</i> Flavonols: Health Benefits, Molecular Targets, and BioavailabilityDamini Kothari0Woo-Do Lee1Soo-Ki Kim2Department of Animal Science and Technology, Konkuk University, Seoul 05029, KoreaDepartment of Animal Science and Technology, Konkuk University, Seoul 05029, KoreaDepartment of Animal Science and Technology, Konkuk University, Seoul 05029, Korea<i>Allium</i> species are revered worldwide as vegetables, condiments, and spices as well as the therapeutic agents in traditional medicine. The bioactive compounds in alliums mainly include organosulfur compounds, polyphenols, dietary fibers, and saponins. Flavonoids, particularly flavonols from alliums, have been demonstrated to have the antioxidant, anticancer, hypolipidemic, anti-diabetic, cardioprotective, neuroprotective, and antimicrobial activities. However, flavonols are mostly characterized from onions and have not been comprehensively reviewed across different species. This article therefore focuses on flavonol profiles from different <i>Allium</i> species, their health effects, underlying molecular mechanisms, and bioavailability. Intriguingly, the functional health effects of flavonols were mainly ascribed to their antioxidant and anti-inflammatory activities involving a cascade of multiple signaling pathways. Although the <i>Allium</i>-derived flavonols offer tremendous potential in preventing chronic disease risks, in-depth studies are needed to translate their clinical application.https://www.mdpi.com/2076-3921/9/9/888<i>Allium</i>flavonolshealth benefitsantioxidant effectsmolecular targetsbioavailability |
| spellingShingle | Damini Kothari Woo-Do Lee Soo-Ki Kim <i>Allium</i> Flavonols: Health Benefits, Molecular Targets, and Bioavailability Antioxidants <i>Allium</i> flavonols health benefits antioxidant effects molecular targets bioavailability |
| title | <i>Allium</i> Flavonols: Health Benefits, Molecular Targets, and Bioavailability |
| title_full | <i>Allium</i> Flavonols: Health Benefits, Molecular Targets, and Bioavailability |
| title_fullStr | <i>Allium</i> Flavonols: Health Benefits, Molecular Targets, and Bioavailability |
| title_full_unstemmed | <i>Allium</i> Flavonols: Health Benefits, Molecular Targets, and Bioavailability |
| title_short | <i>Allium</i> Flavonols: Health Benefits, Molecular Targets, and Bioavailability |
| title_sort | i allium i flavonols health benefits molecular targets and bioavailability |
| topic | <i>Allium</i> flavonols health benefits antioxidant effects molecular targets bioavailability |
| url | https://www.mdpi.com/2076-3921/9/9/888 |
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