Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: a Promising New Target for Metastatic Cancer
The balance of endogenous angiogenic factors in the body is responsible for the homeostatic control of angiogenesis during normal physiological circumstances, with the disruption of this fragile balance leading to pathologic angiogenic events such as those involved in cancer progression. This review...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Cell Physiol Biochem Press GmbH & Co KG
2012-03-01
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| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/350069 |
| _version_ | 1819066313729900544 |
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| author | Marice B. Alcantara Crispin R. Dass |
| author_facet | Marice B. Alcantara Crispin R. Dass |
| author_sort | Marice B. Alcantara |
| collection | DOAJ |
| description | The balance of endogenous angiogenic factors in the body is responsible for the homeostatic control of angiogenesis during normal physiological circumstances, with the disruption of this fragile balance leading to pathologic angiogenic events such as those involved in cancer progression. This review focuses regulation of the pro-angiogenic factors membrane type-1 matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) by the anti-angiogenic factor pigment epithelium-derived factor (PEDF) in the contexts of angiogenesis, cancer cell proliferation and metastasis. Understanding the role of PEDF in the regulation of MT1-MMP and MMP-2 as it pertains to cancer control is important in order to understand whether and how such associations provide a novel target for cancer therapy. |
| first_indexed | 2024-12-21T16:00:23Z |
| format | Article |
| id | doaj.art-e6eaa3b57248435e9a09dd92752e63c5 |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-21T16:00:23Z |
| publishDate | 2012-03-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-e6eaa3b57248435e9a09dd92752e63c52022-12-21T18:58:00ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782012-03-01314-548749410.1159/000350069350069Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: a Promising New Target for Metastatic CancerMarice B. AlcantaraCrispin R. DassThe balance of endogenous angiogenic factors in the body is responsible for the homeostatic control of angiogenesis during normal physiological circumstances, with the disruption of this fragile balance leading to pathologic angiogenic events such as those involved in cancer progression. This review focuses regulation of the pro-angiogenic factors membrane type-1 matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) by the anti-angiogenic factor pigment epithelium-derived factor (PEDF) in the contexts of angiogenesis, cancer cell proliferation and metastasis. Understanding the role of PEDF in the regulation of MT1-MMP and MMP-2 as it pertains to cancer control is important in order to understand whether and how such associations provide a novel target for cancer therapy.http://www.karger.com/Article/FullText/350069CollagenMMP-14CancerPEDFMetastasisMT1-MMPMMP-2 |
| spellingShingle | Marice B. Alcantara Crispin R. Dass Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: a Promising New Target for Metastatic Cancer Cellular Physiology and Biochemistry Collagen MMP-14 Cancer PEDF Metastasis MT1-MMP MMP-2 |
| title | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: a Promising New Target for Metastatic Cancer |
| title_full | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: a Promising New Target for Metastatic Cancer |
| title_fullStr | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: a Promising New Target for Metastatic Cancer |
| title_full_unstemmed | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: a Promising New Target for Metastatic Cancer |
| title_short | Regulation of MT1-MMP and MMP-2 by the Serpin PEDF: a Promising New Target for Metastatic Cancer |
| title_sort | regulation of mt1 mmp and mmp 2 by the serpin pedf a promising new target for metastatic cancer |
| topic | Collagen MMP-14 Cancer PEDF Metastasis MT1-MMP MMP-2 |
| url | http://www.karger.com/Article/FullText/350069 |
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