Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation
Increasing observational and experimental trial data have shown that mental stress can lead to an increase in adverse clinical cardiovascular events. Mental stress affects the heart by inducing ischaemia and precipitating myocardial infarction (MI) or direct myocardial injury. Mental stress leads to...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-12-01
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| Series: | General Psychiatry |
| Online Access: | https://gpsych.bmj.com/content/36/6/e101282.full |
| _version_ | 1797371041398390784 |
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| author | Jinghong Chen Hean Teik Ong |
| author_facet | Jinghong Chen Hean Teik Ong |
| author_sort | Jinghong Chen |
| collection | DOAJ |
| description | Increasing observational and experimental trial data have shown that mental stress can lead to an increase in adverse clinical cardiovascular events. Mental stress affects the heart by inducing ischaemia and precipitating myocardial infarction (MI) or direct myocardial injury. Mental stress leads to systemic inflammation. Inflammation is known to cause rapid atheromatous plaque progression, instability and thrombosis—the classic type 1 MI. Inflammation can also lead to type 2 MI or myocarditis and injury. The published data linking systemic inflammation, mental stress and cardiovascular disease will be reviewed to establish the linkage between mind and heart, thereby highlighting the importance of holistically managing the patient, not only addressing separate organ systems. Finally, recent trial evidence showing the value of anti-inflammatory drugs in cardiovascular and mental conditions will be briefly considered. |
| first_indexed | 2024-03-08T18:13:09Z |
| format | Article |
| id | doaj.art-e6ed9d8b0a3b40c3ad3b8471faff09ab |
| institution | Directory Open Access Journal |
| issn | 2517-729X |
| language | English |
| last_indexed | 2024-03-08T18:13:09Z |
| publishDate | 2023-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | General Psychiatry |
| spelling | doaj.art-e6ed9d8b0a3b40c3ad3b8471faff09ab2023-12-31T22:00:08ZengBMJ Publishing GroupGeneral Psychiatry2517-729X2023-12-0136610.1136/gpsych-2023-101282Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammationJinghong Chen0Hean Teik Ong12 Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China1 Cardiology, HT Ong Heart Clinic, Georgetown, Penang, MalaysiaIncreasing observational and experimental trial data have shown that mental stress can lead to an increase in adverse clinical cardiovascular events. Mental stress affects the heart by inducing ischaemia and precipitating myocardial infarction (MI) or direct myocardial injury. Mental stress leads to systemic inflammation. Inflammation is known to cause rapid atheromatous plaque progression, instability and thrombosis—the classic type 1 MI. Inflammation can also lead to type 2 MI or myocarditis and injury. The published data linking systemic inflammation, mental stress and cardiovascular disease will be reviewed to establish the linkage between mind and heart, thereby highlighting the importance of holistically managing the patient, not only addressing separate organ systems. Finally, recent trial evidence showing the value of anti-inflammatory drugs in cardiovascular and mental conditions will be briefly considered.https://gpsych.bmj.com/content/36/6/e101282.full |
| spellingShingle | Jinghong Chen Hean Teik Ong Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation General Psychiatry |
| title | Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation |
| title_full | Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation |
| title_fullStr | Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation |
| title_full_unstemmed | Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation |
| title_short | Mental stress, atheroma, myocardial ischaemia and injury: the link is inflammation |
| title_sort | mental stress atheroma myocardial ischaemia and injury the link is inflammation |
| url | https://gpsych.bmj.com/content/36/6/e101282.full |
| work_keys_str_mv | AT jinghongchen mentalstressatheromamyocardialischaemiaandinjurythelinkisinflammation AT heanteikong mentalstressatheromamyocardialischaemiaandinjurythelinkisinflammation |