Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration

Ablation of pigment epithelium-derived factor receptor (PEDF-R/Pnpla2) causes photoreceptor degeneration

Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2) gene that codes for pigment epithelium-derived factor receptor (PEDF-R) (also known as ATGL). PEDF-R exhibits phospholipase activity that mediates the neurotrophic action of its ligand PEDF. Because phospholipids...

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Bibliographic Details
Main Authors: Alexandra Bernardo-Colón, Lijin Dong, Mones Abu-Asab, Richard S. Brush, Martin-Paul Agbaga, S. Patricia Becerra
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Lipid Research
Subjects:
Eye
eye/retina
PEDF-R/ATGL
phospholipase A2
phospholipids
photoreceptors
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523000317

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