The importance of genome sequence quality to microbial comparative genomics
Abstract The quality of microbial genome sequences has been a concern ever since the emergence of genome sequencing. The quality of the genome assemblies is dependent on the sequencing technology used and the aims for which the sequence was generated. Novel sequencing and bioinformatics technologies...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | BMC Genomics |
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| Online Access: | http://link.springer.com/article/10.1186/s12864-019-6014-5 |
| _version_ | 1818883547258159104 |
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| author | Theo H. M. Smits |
| author_facet | Theo H. M. Smits |
| author_sort | Theo H. M. Smits |
| collection | DOAJ |
| description | Abstract The quality of microbial genome sequences has been a concern ever since the emergence of genome sequencing. The quality of the genome assemblies is dependent on the sequencing technology used and the aims for which the sequence was generated. Novel sequencing and bioinformatics technologies are not intrinsically better than the older technologies, although they are generally more efficient. In this correspondence, the importance for comparative genomics of additional manual assembly efforts over autoassembly and careful annotation is emphasized. |
| first_indexed | 2024-12-19T15:35:23Z |
| format | Article |
| id | doaj.art-e6eeb0d28a9249d688bf023942805305 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-12-19T15:35:23Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-e6eeb0d28a9249d688bf0239428053052022-12-21T20:15:38ZengBMCBMC Genomics1471-21642019-08-012011410.1186/s12864-019-6014-5The importance of genome sequence quality to microbial comparative genomicsTheo H. M. Smits0Environmental Genomics and Systems Biology Research Group, Institute of Natural Resource Sciences (IUNR), Zurich University of Applied Sciences ZHAWAbstract The quality of microbial genome sequences has been a concern ever since the emergence of genome sequencing. The quality of the genome assemblies is dependent on the sequencing technology used and the aims for which the sequence was generated. Novel sequencing and bioinformatics technologies are not intrinsically better than the older technologies, although they are generally more efficient. In this correspondence, the importance for comparative genomics of additional manual assembly efforts over autoassembly and careful annotation is emphasized.http://link.springer.com/article/10.1186/s12864-019-6014-5AssemblyTaxonomyGenomesSequencingAnnotations |
| spellingShingle | Theo H. M. Smits The importance of genome sequence quality to microbial comparative genomics BMC Genomics Assembly Taxonomy Genomes Sequencing Annotations |
| title | The importance of genome sequence quality to microbial comparative genomics |
| title_full | The importance of genome sequence quality to microbial comparative genomics |
| title_fullStr | The importance of genome sequence quality to microbial comparative genomics |
| title_full_unstemmed | The importance of genome sequence quality to microbial comparative genomics |
| title_short | The importance of genome sequence quality to microbial comparative genomics |
| title_sort | importance of genome sequence quality to microbial comparative genomics |
| topic | Assembly Taxonomy Genomes Sequencing Annotations |
| url | http://link.springer.com/article/10.1186/s12864-019-6014-5 |
| work_keys_str_mv | AT theohmsmits theimportanceofgenomesequencequalitytomicrobialcomparativegenomics AT theohmsmits importanceofgenomesequencequalitytomicrobialcomparativegenomics |