The Relationship between Furin and Chronic Inflammation in the Progression of Cervical Intraepithelial Neoplasia to Cancer: A Cross-Sectional Study
Objective: The current study aimed to delineate the relationship between furin and chronic inflammation while cervical intraepithelial neoplasia progresses to cancer. Study Design: This cross-sectional study included 81 women who required colposcopic examinations. The study groups were formed based...
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MDPI AG
2023-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/19/4878 |
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| author | Selim Afsar Gulay Turan Gurhan Guney Gozde Sahin Merve Aldıkactıoglu Talmac Cigdem Usul Afsar |
| author_facet | Selim Afsar Gulay Turan Gurhan Guney Gozde Sahin Merve Aldıkactıoglu Talmac Cigdem Usul Afsar |
| author_sort | Selim Afsar |
| collection | DOAJ |
| description | Objective: The current study aimed to delineate the relationship between furin and chronic inflammation while cervical intraepithelial neoplasia progresses to cancer. Study Design: This cross-sectional study included 81 women who required colposcopic examinations. The study groups were formed based on pathological results: Group I included women with cervical intraepithelial neoplasia (CIN) I (n = 30); Group II included women with CIN II-III (n = 28); and Group III included women with cervical cancer (CC) (n = 23). Furin, ki-67, and p16 levels were evaluated based on immunostaining intensity. The inflammatory indices were calculated in parallel with the literature from routine blood samples retrieved within one week before the procedure. Results: Furin expression gradually increased from CIN I to CIN II-III and from CIN II-III to CC, respectively (<i>p</i> < 0.001, <i>p</i> = 0.005). NLR, MLR, PLR, and SII were significantly higher in the CC group (<i>p</i> < 0.001). ROC curve analysis unveiled that NLR, MLR, PLR, and SII predicted the presence of CC with a cutoff value of 2.39 for NLR (sensitivity: 91.3%, specificity: 63.8%, AUROC: 0.79, <i>p</i> < 0.001); a cutoff value of 0.27 for MLR (sensitivity: 78.3%, specificity: 72.4%, AUROC: 0.77, <i>p</i> = 0.009); a cutoff value of 123 for PLR (sensitivity: 100%, specificity: 41.4%, AUROC: 0.70, <i>p</i> = 0.04); and a cutoff value of 747 for SII (sensitivity: 69.6%, specificity: 90.7%, AUROC: 0.71, <i>p</i> = 0.014). Conclusion: Furin expression increased gradually in parallel with the severity of cervical intraepithelial neoplasia. The inflammatory indices were higher in the presence of CC and denoted a good discrimination ability for predicting cervical cancer. |
| first_indexed | 2024-03-10T21:48:08Z |
| format | Article |
| id | doaj.art-e6f137b2bfb443d9aa99e11f4622329e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T21:48:08Z |
| publishDate | 2023-10-01 |
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| series | Cancers |
| spelling | doaj.art-e6f137b2bfb443d9aa99e11f4622329e2023-11-19T14:11:52ZengMDPI AGCancers2072-66942023-10-011519487810.3390/cancers15194878The Relationship between Furin and Chronic Inflammation in the Progression of Cervical Intraepithelial Neoplasia to Cancer: A Cross-Sectional StudySelim Afsar0Gulay Turan1Gurhan Guney2Gozde Sahin3Merve Aldıkactıoglu Talmac4Cigdem Usul Afsar5Department of Obstetrics & Gynecology, School of Medicine, Balıkesir University, Cagis Yerleskesi, Bigadic Yolu 17. km, Balikesir 10145, TurkeyDepartment of Pathology, School of Medicine, Balıkesir University, Balıkesir 10145, TurkeyDepartment of Obstetrics & Gynecology, School of Medicine, Balıkesir University, Cagis Yerleskesi, Bigadic Yolu 17. km, Balikesir 10145, TurkeyDepartment of Gynecologic Oncology, Health Sciences University, Istanbul 34668, TurkeyDepartment of Gynecologic Oncology, Health Sciences University, Istanbul 34668, TurkeyDepartment of Medical Oncology, Health Sciences University, Istanbul 34668, TurkeyObjective: The current study aimed to delineate the relationship between furin and chronic inflammation while cervical intraepithelial neoplasia progresses to cancer. Study Design: This cross-sectional study included 81 women who required colposcopic examinations. The study groups were formed based on pathological results: Group I included women with cervical intraepithelial neoplasia (CIN) I (n = 30); Group II included women with CIN II-III (n = 28); and Group III included women with cervical cancer (CC) (n = 23). Furin, ki-67, and p16 levels were evaluated based on immunostaining intensity. The inflammatory indices were calculated in parallel with the literature from routine blood samples retrieved within one week before the procedure. Results: Furin expression gradually increased from CIN I to CIN II-III and from CIN II-III to CC, respectively (<i>p</i> < 0.001, <i>p</i> = 0.005). NLR, MLR, PLR, and SII were significantly higher in the CC group (<i>p</i> < 0.001). ROC curve analysis unveiled that NLR, MLR, PLR, and SII predicted the presence of CC with a cutoff value of 2.39 for NLR (sensitivity: 91.3%, specificity: 63.8%, AUROC: 0.79, <i>p</i> < 0.001); a cutoff value of 0.27 for MLR (sensitivity: 78.3%, specificity: 72.4%, AUROC: 0.77, <i>p</i> = 0.009); a cutoff value of 123 for PLR (sensitivity: 100%, specificity: 41.4%, AUROC: 0.70, <i>p</i> = 0.04); and a cutoff value of 747 for SII (sensitivity: 69.6%, specificity: 90.7%, AUROC: 0.71, <i>p</i> = 0.014). Conclusion: Furin expression increased gradually in parallel with the severity of cervical intraepithelial neoplasia. The inflammatory indices were higher in the presence of CC and denoted a good discrimination ability for predicting cervical cancer.https://www.mdpi.com/2072-6694/15/19/4878furincervical intraepithelial neoplasiacervical cancerneutrophil-to-lymphocyte ratiomonocyte-to-lymphocyte ratioplatelet-to-lymphocyte ratio |
| spellingShingle | Selim Afsar Gulay Turan Gurhan Guney Gozde Sahin Merve Aldıkactıoglu Talmac Cigdem Usul Afsar The Relationship between Furin and Chronic Inflammation in the Progression of Cervical Intraepithelial Neoplasia to Cancer: A Cross-Sectional Study Cancers furin cervical intraepithelial neoplasia cervical cancer neutrophil-to-lymphocyte ratio monocyte-to-lymphocyte ratio platelet-to-lymphocyte ratio |
| title | The Relationship between Furin and Chronic Inflammation in the Progression of Cervical Intraepithelial Neoplasia to Cancer: A Cross-Sectional Study |
| title_full | The Relationship between Furin and Chronic Inflammation in the Progression of Cervical Intraepithelial Neoplasia to Cancer: A Cross-Sectional Study |
| title_fullStr | The Relationship between Furin and Chronic Inflammation in the Progression of Cervical Intraepithelial Neoplasia to Cancer: A Cross-Sectional Study |
| title_full_unstemmed | The Relationship between Furin and Chronic Inflammation in the Progression of Cervical Intraepithelial Neoplasia to Cancer: A Cross-Sectional Study |
| title_short | The Relationship between Furin and Chronic Inflammation in the Progression of Cervical Intraepithelial Neoplasia to Cancer: A Cross-Sectional Study |
| title_sort | relationship between furin and chronic inflammation in the progression of cervical intraepithelial neoplasia to cancer a cross sectional study |
| topic | furin cervical intraepithelial neoplasia cervical cancer neutrophil-to-lymphocyte ratio monocyte-to-lymphocyte ratio platelet-to-lymphocyte ratio |
| url | https://www.mdpi.com/2072-6694/15/19/4878 |
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